Results 131 to 140 of about 1,915,493 (292)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Technological opportunity, long-run growth and convergence [PDF]

We derive an R&D-based semi-endogenous growth model where technological progress depends on the available amount of technological opportunity. Incremental innovations provide direct increases in the knowledge stock but they reduce technological ...
Ingmar, SCHUMACHER, Jakub, GROWIEC
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Recent advances in supported metal catalysts for CO2 methanation: mechanisms, materials design, and the promise of perovskite-based supports

Energy Conversion and Management: X
The mitigation of climate change demands transformative approaches to reduce carbon emissions and utilizing carbon dioxide (CO2) as a valuable feedstock.
Lan Zhang, Zhi Li, Ying Gao, Qingshan Li, Zhihua Deng, Bin Miao, Hongquan He, Chee Kok Poh, Lili Zhang, Siew Hwa Chan   +9 more
doaj   +1 more source

Agglomeration economies, knowledge spillovers, technological diversity and spatial clustering of innovations. [PDF]

This paper explores the spatial patterns of innovative activities from an empirical perspective and with reference to the Italian case. Using patent and other economic data at the NUTS 3 level (provinces), it borrows methodology and techniques from ...
Stefano Breschi
core  

Regional efficiency in generating technological knowledge [PDF]

, 2010
There is broad consensus among economists that regions' competitiveness heavily relies on their ability to produce innovative goods and services (Baumol 1967, Romer 1990, Grossman and Helpman 1991, Barro and Sala-i-Martin 1997, Los and Verspagen 2006 ...
Rauland, Jan, Schaffer, Axel
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Network Formation and Strategic Firm Behaviour to Explore and Exploit [PDF]

The aim of this paper is to investigate the effect of technological opportunities and knowledge tacitness on inter-firm network formation, under two different industry regimes.
Müge �zman
core  

Exploring the role of servitization to overcome barriers for innovative energy efficiency technologies – the case of public LED street lighting in German municipalities [PDF]

, 2015
In this paper we analyse the case for public application of LED street lighting. Drawing from the energy services literature and transaction cost economics, we compare modes of lighting governance for modernisation.
Nolden, Colin, Polzin, Friedemann, von Flotow, Paschen   +2 more
core   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source