Results 41 to 50 of about 7,420,775 (255)

Ablation technologies

Surgery Open Science, 2022
Ablative therapies have recently emerged as an alternate to the gold-standard liver resection in treatment of malignant liver tumors. These modalities include radiofrequency ablation and microwave ablation which utilize thermocoagulative energy and microwave energy, respectively, to create a complete necrosis zone encircling the lesion. In this review,
Onuralp Ergun, MD, Mohammed Elshamy, MD, Eren Berber, MD   +2 more
openaire   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Smart Cities: Necessity and Development Strategies

Informaciâ i Innovacii, 2020
In the twenty-first century different countries and cities are increasingly seeking to introduce quality improvements in their livelihoods, generate for its residents an environment that is called “smart city” on the basis of high technologies.
L. V. Shkvarya, A. S. Semenov
doaj   +1 more source

Mechanism of Managing Digital Ecosystem Development

Вестник Российского экономического университета имени Г. В. Плеханова, 2022
When economic landscape is changing both ecosystems development and their effective management became very important. The author shows goals, objectives and principles necessary for effective functioning of the mechanism of managing ecosystem development
O. E. Kalenov
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The learning technologies of the future: technologies that learn? [PDF]

, 2009
Higher Education Institutions (HEIs) operate in a borderless and complex environment, abundant in potentially useful information. The Creating Academic Learning Futures (CALF) research project, carried out in partnership by the University of Leicester ...
Romenska, Sandra
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

IMPROVEMENT OF FINANCIAL SUPPORT OF RAISING PRODUCT QUALITY WITH THE HELP OF SMART MANAGEMENT INFORMATION SYSTEMS [PDF]

Proceedings on Engineering Sciences
We analysed the directions for improving financing for the growth of quality in the conditions of smart production and revealed the advantages and features of their realisation in developing and developed countries.
Sultonali U. Mekhmonov , Mukaddas A. Dzhorobaeva , Maria A. Dzhenalieva, Ulyana V. Ashmarina , Aghavni G. Hakobyan   +4 more
doaj   +1 more source