Results 61 to 70 of about 7,354,647 (255)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Фармация и фармакология (Пятигорск), 2015 То elaborate the composition of the suppositories with riboxiniirn we have studied physical and chemical, and structural and mechanical characteristics of different bases. Witepsol-H15 was chosen as a preferable base.
O. V. Michnik +4 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Actualidades Investigativas en Educación, 2013 Actualmente la sociedad atraviesa una etapa muy interesante, incidida por las tecnologías de la información y la comunicación (TIC), nuevos descubrimientos de la neurociencia que proponen formas distintas de analizar los estilos de aprendizaje, además ...
José Laurian Ramírez Díaz
doaj +1 more source
Technologies for the Disabled [PDF]
, 2017 Nowadays computers have taken the dominant role in our society.Most jobs now require access to computers and the Internet. But what happens if a person is blind, deaf or physically disabled?
Grechikhina, Julia +2 more
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Methods and technologies of disposal of poly-chloride biphenyls in transformer oils
Вестник Научно-исследовательского института железнодорожного транспорта, 2016 A review of the main methods of disposal of waste containing polychlorinated biphenyls (PCBs) is presented. It is shown that a reliable, environmentally friendly and efficient process does not exist, and, apparently, it is impossible to create a ...
V. M. Bel’Kov
doaj +1 more source
Technologies may help thinking [PDF]
, 2006 The objective of teachers’ personal and professional development is an excellent reason to reflect upon the innovation issues in education and a rare opportunity to implement the use of portfolios in the teaching practices.
Costa, Fernando Albuquerque +2 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source