Results 41 to 50 of about 424,358 (303)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Electrostatic charge in pharmaceutical systems [PDF]
, 2013 Electrostatic technology has been applied in novel applications such as electrospraying for respiratory delivery and pharmaceutical sterilization. Results from computational models suggest that charges on aerosolized particles may affect deposition in ...
Kwok, PCL, Chan, HK
core
Impact of DNA-Encoded Chemical Library Technology on Drug Discovery
CHIMIA, 2022 DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies.
Michelle Keller +2 more
doaj +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
USAGE OF 3D PRINTER TECHNOLOGY IN MEDICAL AND PHARMACEUTICAL FIELDS: A REVIEW [PDF]
, 2019 Along with the developing technology, 3D printers have found broad applications in medical and pharmaceutical fields. Precise digital control over layer by layerprinting given by 3D printers allows drugs, cosmetics and medical devices like prostheses to ...
Evren ALGIN YAPAR +3 more
core +1 more source
Finite Element Analysis and Modeling in Pharmaceutical Tableting [PDF]
, 2022 Finite element analysis (FEA) is a computational method providing numerical solutions and mathematical modeling of complex physical phenomena that evolve during compression tableting of pharmaceutical powders. Since the early 2000s, FEA has been utilized
Ioannis Nikolakakis +2 more
core +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Preparation and testing of solutions for organ perfusion and preservation in transplantation [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. Histidine-tryptophan-ketoglutarate (HTK) solution is the most frequently used solution for the preservation of abdominal organs by leading transplant centers worldwide.
Antunović Mirjana, Aleksić Dragana
doaj +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Modeling and Simulation of Process Technology for Nanoparticulate Drug Formulations—A Particle Technology Perspective [PDF]
, 2020 Crystalline organic nanoparticles and their amorphous equivalents (ONP) have the potential to become a next-generation formulation technology for dissolution-rate limited biopharmaceutical classification system (BCS) class IIa molecules if the following ...
Jens Uhlemann +9 more
core +2 more sources