Results 41 to 50 of about 876,919 (302)
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Impact of DNA-Encoded Chemical Library Technology on Drug Discovery
CHIMIA, 2022 DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies.
Michelle Keller +2 more
doaj +1 more source
A New Journal in the Field of Pharmaceutical Technology Is Born [PDF]
, 2016 Launching a new journal is always an adventure. There are so many tasks, so many people to convince from the publisher to the authors. After many discussions at the GERPAC’s meetings every year in the south of France, we decided that the game was worth ...
F. Lagarce +2 more
core +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Preparation and testing of solutions for organ perfusion and preservation in transplantation [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. Histidine-tryptophan-ketoglutarate (HTK) solution is the most frequently used solution for the preservation of abdominal organs by leading transplant centers worldwide.
Antunović Mirjana, Aleksić Dragana
doaj +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Регуляторные исследования и экспертиза лекарственных средствINTRODUCTION. The strengthening of the health system and the improvement of access to medicines directly depend on the development and marketing authorisation of national innovative medicinal products.
A. S. Koshevenko +4 more
doaj +1 more source
Reverse Technology Transfer: A Patent Citation Analysis of the European Chemical and Pharmaceutical sectors [PDF]
One consequence of the internationalisation of R&D, particularly in high-tech sectors such as chemicals and pharmaceuticals, may be the transfer of foreign technology from the multinational to other firms in its home country.
Criscuolo,Paola
core +4 more sources
An Overview of Progress in the International Regulation of the Pharmaceutical Industry [PDF]
, 2002 [Excerpt] “The pharmaceutical industry, a significant source of healthcare throughout the world, has several features that distinguish it from the rest of the health industry.
Burakoff, Aaron, Harvard University +1 more
core +1 more source