Results 51 to 60 of about 876,919 (302)

Texture analysis as a tool to study the kinetics of wet agglomeration processes [PDF]

open access: yes, 2015
In this work wet granulation experiments were carried out in a planetary mixer with the aim to develop a novel analytical tool based on surface texture analysis.
Codemo, Carlo   +5 more
core   +4 more sources

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

Advanced Pharmaceutical Science and Technology in Israel

open access: yesPharmaceutics
Israel has a significant and diverse history of ground-breaking research and development in pharmaceutical sciences and technology within academic settings, pharma/biopharma companies, and the biotechnology community [...]
Arik Dahan
doaj   +1 more source

Pharmaceutical Technology in Practice: A Personal View

open access: yesPharmaceutical Technology in Hospital Pharmacy, 2018
This opinion piece argues that the collective knowledge of drugs and medicines, their nature, formulation and manufacture, their delivery and evaluation is unique to pharmacy and it reasserts the fact that science underpins the clinical use of medicines.
Florence Alexander T.
doaj   +1 more source

Pharmaceutical Technology: Drug Delivery, Formulation, and Process Research

open access: yesCHIMIA, 2006
This paper describes in the introduction the actual research trends in the area of pharmaceutical technology and the impact of FDA's PAT (Process Analytical Technology) Initiative on this research field.
Hans Leuenberger
doaj   +1 more source

Step-change in Enhancing Extrusion as a Unit Operation [PDF]

open access: yes, 2005
YesExtrusion-a unit operation in polymer processing has been in extensive use since the great age of plastic technology. It is a simple operation that enables within one equipment the sequential conveying of solid polymer chips or powder, their melting ...
Benkreira, Hadj
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Investigating the removal of some pharmaceutical compounds in hospital wastewater treatment plants operating in Saudi Arabia [PDF]

open access: yes, 2016
The concentrations of 12 pharmaceutical compounds (atenolol, erythromycin, cyclophosphamide, paracetamol, bezafibrate, carbamazepine, ciprofloxacin, caffeine, clarithromycin, lidocaine, sulfamethoxazole and Nacetylsulfamethoxazol (NACS)) were ...
Akunna, Joseph C.   +3 more
core   +3 more sources

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