Results 31 to 40 of about 250,624 (247)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Evaluating a University-Wide Digital Skills Programme: Understanding the Student Journey

Education Sciences
Digital competencies are critical to success in higher education, and yet these skills are often not explicitly taught to students. We have previously designed and evaluated a university-wide digital skills programme using quantitative methods.
Nabila A. S. Raji, Eleanor J. Dommett
doaj   +1 more source

Weaknesses of ICT integration in the initial teacher education curriculum

Computers and Education Open, 2023
The article presents a Portuguese national study on integrating information and communication technologies (ICT) in initial teacher education courses (ITE), which sought to highlight to what extent ICT are presently considered in the training curriculum ...
Cristiano Rogério Vieira, Neuza Pedro
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dataset on student experiences and perceptions of Emergency Remote Teaching (ERT) in an Irish University

Data in Brief, 2022
This paper presents a dataset from a survey of student experiences and perceptions of Emergency Remote Teaching (ERT) during the COVID-19 pandemic in the Munster Technological University, a new higher education institute in the south-west of Ireland ...
Gearóid Ó. Súilleabháin, Tom Farrelly, Sean Lacey   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Digital Teaching and Digital Medicine: A national initiative is needed

GMS Journal for Medical Education, 2018
The advancing digitization of the healthcare system requires that in the future digital skills should be communicated to students much more. In addition, digital teaching and learning technologies should be used wherever they offer real benefits over ...
Haag, Martin, Igel, Christoph, Fischer, Martin R., German Medical Education Society (GMA), Committee “Digitization – Technology-Assisted Learning and Teaching”, Joint working group “Technology-enhanced Teaching and Learning in Medicine (TeLL)” of the German Association for Medical Informatics, Biometry and Epidemiology (gmds) and the German Informatics Society (GI)   +4 more
doaj   +1 more source