Results 101 to 110 of about 19,872,397 (345)
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Аграрная наука Евро-Северо-ВостокаThe article presents the results of research of the influence of various cultivation technologies on the contamination of spring wheat crops and its yield for 2022–2023 in the conditions of the Nizhny Novgorod region on light gray loamy forest soil ...
A. V. Ivenin +4 more
doaj +1 more source
Visual Surveillance Within the EU General Data Protection Regulation: A Technology Perspective
IEEE Access, 2019 From an individual's perspective, technological advancement has merits and demerits. Video captured by surveillance cameras while a person goes about their daily life may improve their personal safety but the images collected may also represent an ...
Mamoona N. Asghar +5 more
doaj +1 more source
Research and technology program perspectives for general aviation and commuter aircraft [PDF]
The uses, benefits, and technology needs of the U.S. general aviation industry were studied in light of growing competition from foreign general aviation manufacturers, especially in the commuter and business jet aircraft ...
Bauchspies, J. S., Simpson, W. E.
core +1 more source
Space Place: How Astronomers "Detwinkle" the Stars [PDF]
, 1999 This classroom activity provides an explanation and kinesthetic activity to demonstrate how Earth's atmosphere distorts starlight and how advanced telescope technology (adaptive optics) is used to compensate for this distortion.
core
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Social approaches to technological systems
Trilogía Ciencia Tecnología Sociedad, 2014 this article presents a characterization of technological systems from social approaches. This is a set of elements that seek to define both the functioning and the role of people in technological systems.
Carlos Osorio Marulanda
doaj +1 more source
Investigating scientific literacy: Scientist’s habits of mind as evidenced by their rationale of science and religious beliefs [PDF]
, 2006 Science and technology have been incredibly success¬ful in purely technical terms. For instance, international air travel, space flight, and curing of hitherto untreatable medical illnesses all are now routine events.
Coll, Richard K. +2 more
core
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source