Results 41 to 50 of about 5,547,029 (292)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Re-reengineering the dream: agility as competitive adaptability [PDF]

, 2014
Organizational adaptation and transformative change management in technology-based organizations is explored in the context of collaborative alliances.
Allan F. McLay
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Manufactura biológica e inteligente: atributos de la vida aplicados al desarrollo tecnológico

Ingeniería e Investigación, 2009
Los entornos altamente dinámicos caracterizados por el predominio del conocimiento como motor del desarrollo hacen que sea necesario abordar problemáticas específicas a través de enfoques multidisciplinarios.
Claudia Nelcy Jiménez Hernández, Óscar Fernando Castellanos Domínguez, Luz Alexandra Montoya Restrepo   +2 more
doaj  

Strategies to Mitigate Technoference Among Indian Youth: A Qualitative Study Using Semi-Structured Interviews

Journal of Psychiatry Spectrum
Background: The growing use of digital devices has led to the phenomenon of “technoference” – technology-induced disruptions in interpersonal communication, particularly among youth.
M. S. Neeraj, B. Parthasarathy Nirmala, N. Janardhana, Manoj Kumar Sharma   +3 more
doaj   +1 more source

Applications of space technology to water resources management [PDF]

, 1977
Space technology transfer is discussed in terms of applying visible and infrared remote sensing measurement to water resources management. Mapping and monitoring of snowcovered areas, hydrologic land use, and surface water areas are discussed, using ...
Salomonson, V. V.
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Creativity matters, synergies between Spanish ICT sector and higher education performance

Cogent Education
This study examines the alignment between skills taught at Spanish technological universities and the demands of the national ICT sector over 15 years, spanning from 2008 to 2023.
Ariadna Llorens, Enric Trullols, Francisco Iniesto, Covadonga Rodrigo, Nikola Petrovic   +4 more
doaj   +1 more source

Selected Instruments for Management of Technology Development [PDF]

, 2013
Polska dysponuje pewnymi możliwościami rozwijania nowoczesnych technologii, także tych, które aktualnie znajdują się w pierwszych fazach cyklu życia (np. nanotechnologii, spintroniki, fizykochemii zjawisk powierzchniowych, robotyki itd.), i mają wysoki
Piasecki, Bogdan, Rogut, Anna
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source