Risks of dementia and stroke in patients with hypertension using telmisartan or other renin‑angiotensin system inhibitors. [PDF]
Alzheimers DementAbstract INTRODUCTION The aim of this study was to investigate the cognitive and cerebrovascular outcomes of patients with hypertension (HTN) receiving various renin‐angiotensin system (RAS) inhibitors. METHODS We further categorized 39,665 patients with HTN receiving long‐term RAS inhibitor therapy into (1) telmisartan, (2) non‐telmisartan angiotensin
Liu CH +5 more
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A Retrospective Analysis of Human Angiotensin II Receptor Blockers (ARB) Pharmacokinetics, Dosages and C<sub>max</sub> Values for the Experimental Modelling of Pleiotropic and Supratherapeutic Activities. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Angiotensin II (AngII) receptor blockers (ARBs) are medications that lower systolic blood pressure (BP) by antagonizing the AngII type 1 receptor (AT1). However, ARBs have documented or suspected therapeutic properties in diseases not caused by high BP including diabetes, muscular dystrophy, chronic obstructive pulmonary diseases (COPD) and ...
Evans A, Bernatchez P.
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Frontiers in Pharmacology, 2021 Angiotensin II type 1 (AT1) receptor blockers (ARBs), as antihypertensive drugs, have drawn attention for their benefits to individuals with diabetes and prediabetes. However, the direct effects of ARBs on insulin secretion remain unclear. In this study,
Tao Liu +18 more
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Antiproliferative and apoptotic effects of telmisartan in human glioma cells
Cancer Cell International, 2023 Glioblastoma is the most common primary central nervous system tumor in adults. Angiotensin II receptor blockers (ARBs) are broadly applied to treat hypertension.
Yung-Lung Chang +6 more
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High Blood Pressure & Cardiovascular Prevention, 2006 In 2002, my colleagues and I1 suggested that blockade of the renin-angiotensin system may prevent diabetes by promoting adipogenesis, thereby allowing redistribution of fat from dangerous visceral and ectopic fat deposits to less-dangerous subcutaneous depots.
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Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver [PDF]
Yeungnam University Journal of Medicine, 2019 Background Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in addition to common blood pressure ...
Kae Won Cho, Du-Hyong Cho
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Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes [PDF]
, 2008 <b>Background:</b> Adiponectin is secreted by adipose tissue and may play a role in cardiovascular disease. We examined adiponectin levels in patients with type 2 diabetes who participated in the Telmisartan vs.
A. Mimran +23 more
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Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways [PDF]
, 2010 —Telmisartan shows antihypertensive and several pleiotropic effects that interact with metabolic pathways. In the present study we tested the hypothesis that telmisartan prevents adipogenesis in vitro and weight gain in vivo through activation of ...
Cao, Tingbing +10 more
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Cardiovascular Diabetology, 2012 Background Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reported to function as a partial agonist
Shiota Asuka +12 more
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Perspectives in Clinical Research, 2022 Background: Diabetes mellitus is a chronic noncommunicable disease, and hypertension (HT) is the most common comorbidity which affects their quality of life (QoL).
Raj Kumar Bhardwaj +6 more
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