Results 151 to 160 of about 128,505 (270)

Landscape of Somatic and Age‐Related Pathogenic Structural Variations in Hepatocellular Carcinoma Revealed by Long‐Read Sequencing

MedComm, Volume 7, Issue 1, January 2026.
This study leveraged long‐read sequencing (LRS) to provide a comprehensive analysis of structural variations (SVs) in the human hepatocellular carcinoma (HCC) genome. Somatic SVs were found to be more prevalent in HBV‐related HCC, with chromosome 1 emerging as the primary hotspot for these alterations. Notably, HBV‐related HCC exhibited a significantly
Zhewen Wei, Yinghao Cao, Hongchao Liu, Mei Liu, Bolun Zhang, Jianming Ying, Jianqiang Cai, Xinyu Bi, Jianjun Zhao, Jianguo Zhou, Zhiyu Li, Zhen Huang, Jianmei Liu, Xueyan Lv, Zhiwen Luo, Zhicheng Wei, Xiaoshi Zhang, Yi Yang, Yiqiao Deng, Yanjiang Yin, Jinghua Chen, Junbo Liang, Xiaoyue Wang, Yefan Zhang, Hong Zhao   +24 more
wiley   +1 more source

Telomere Length and Human Telomerase Reverse Transcriptase Expression As Markers for Progression and Prognosis of Colorectal Carcinoma [PDF]

, 2004
Ralf Gertler, Robert Rosenberg, Dominik Stricker, Jan Friederichs, Axel Hoos, Martin Werner, Kurt Ulm, Bernhard Holzmann, H. Nekarda, Joerg-Ruediger Siewert   +9 more
openalex   +1 more source

Triptolide inhibits human telomerase reverse transcriptase by downregulating translation factors SP1 and c‑Myc in Epstein‑Barr virus‑positive B lymphocytes

, 2021
Cong Long, Qiu-bo Xu, Ding Li, Yang Liu, Wei Ji, Feng Gao, Yong Ji   +6 more
openalex   +2 more sources

Genomic Perspective on Heterogeneity of Organs and Body Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Organ‐specific and whole‐body intrinsic aging metrics reveal heterogeneous organ aging, which potentially can arise from the interplay between static germline variation, somatic mutations, epigenetic drift, transposable elements, and mitochondrial DNA changes, highlighting genomic pathways for precision, organ‐targeted aging interventions.
Shabnam Salimi, Daniel Raftery, Luigi Ferrucci   +2 more
wiley   +1 more source

Ectopic expression of telomerase enhances osteopontin and osteocalcin expression during osteogenic differentiation of human mesenchymal stem cells from elder donors

Journal of Stem Cells and Regenerative Medicine, 2009
Age related bone loss is one of the most prevalent diseases in the elder population. The osteoblasts are the effectors cells of bone formation and regeneration.
Machado CB, Correa CR, Medrado GC, Leite MF, Goes AM   +4 more
doaj  

A three-state model for the regulation of telomerase by TERRA and hnRNPA1 [PDF]

, 2017
Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin.
Lingner, Joachim, Redon, Sophie, Zemp, Ivo   +2 more
core  

Human telomerase reverse transcriptase as a major therapeutic target in different cancer types [PDF]

, 2019
Zorawar Singh, Priya Khangotra
openalex   +1 more source

Ovarian Aging: A Multifaceted Perspective on Mechanisms

Cell Proliferation, Volume 59, Issue 1, January 2026.
A mechanistic network of ovarian aging, highlighting mitochondrial dysfunction as a central hub interconnected with genetic, metabolic, and inflammatory pathways.
Xiaoqing Zhang, Xinyi Dong, Xue Zhang, Suying Yuan, Qiran Zhang, Zilu Guo, Xiaoxue Yang, Qionghua Wang, Tianlan Yang, Donghui Huang   +9 more
wiley   +1 more source

Constitutive Human Telomerase Reverse Transcriptase Expression Enhances Regenerative Properties of Endothelial Progenitor Cells [PDF]

, 2002
Satoshi Murasawa, Joan Llevadot, Marcy Silver, Jeffrey M. Isner, Douglas W. Losordo, Takayuki Asahara   +5 more
openalex   +1 more source

Metabolic dysfunction‐associated steatotic liver disease, insulin resistance and hepatocellular carcinoma: A deadly triad

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major global cause of liver disease, driven by obesity and insulin resistance (IR). IR promotes hepatic lipid accumulation, inflammation and mitochondrial dysfunction, accelerating MASLD progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Alfredo Caturano, Enes Erul, Roberto Nilo, Davide Nilo, Vincenzo Russo, Luca Rinaldi, Carlo Acierno, Erman Akkus, Katerina Koudelkova, Federica Cerini, Alessandro Rizzo, Ferdinando Carlo Sasso, Leonilde Bonfrate, Antonio Giordano, Hatime Arzu Yaşar, Caterina Conte   +15 more
wiley   +1 more source