Results 131 to 140 of about 45,103 (233)

Recent progress in human telomerase structure and its therapeutic targeting

Frontiers in Molecular Biosciences
Most cancer and stem cells activate telomerase to preserve critical genetic material during cell division. Telomerase is a reverse transcriptase ribonucleoprotein that adds telomeric repeats to chromosome ends, thus overcoming the end-replication problem.
Muaath Ebrahim Almansoori, Abdulrahman Awad, Sarah Dhaiban, Mohammed Turki Alduhoori, Humayun Sharif, Abdulrahim Sajini   +5 more
doaj   +1 more source

Diagnostic Utility of a Cost‐Effective Four‐Gene Next Generation Sequencing Panel for Predicting Papillary Thyroid Carcinoma in Indeterminate Thyroid Cytology: A Multicenter Study in China

Cancer Medicine, Volume 15, Issue 5, May 2026.
This multicenter study of 827 thyroid nodules demonstrates that a targeted NGS 4‐gene panel (BRAF^V600E, TERT promoter, RET fusions, NTRK3 fusion) achieves high diagnostic accuracy (88.2%) and PPV (99.62%) for cytologically indeterminate Bethesda III–V nodules, offering a cost‐effective first‐line molecular test in China. ABSTRACT Molecular testing has
Qiong Jiao, Ling Wu, Bing Wei, Qing Li, Xuling Su, Keyang Sun, Xiaoyue Zhang, Yanli Luo, Zhiyan Liu   +8 more
wiley   +1 more source

Advances in Gene Therapy for Xerostomia: Current Perspectives and Future Directions: A Narrative Review

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Xerostomia, or dry mouth, significantly impairs quality of life and oral health, particularly in patients subjected to radiation therapy or suffering from systemic disorders. This narrative review summarizes the current evidence on the efficacy and safety of gene therapy interventions for xerostomia, exploring innovative ...
Muhammad Usman Bilal, Sarah Alvi, Fatima Humayune, Hasan Mujtaba, Shahzad Ahmad, Shazia Iqbal, Muhammad Farooq Umer   +6 more
wiley   +1 more source

Immunohistochemical localization of hTERT protein in human tissues [PDF]

, 2018
Telomerase is a ribonucleoprotein complex mainly composed of a reverse transcriptase catalytic subunit (telomerase reverse transcriptase gene, hTERT) that copies a template region of its RNA subunit to the end of the telomere.
Benhattar, Jean, Bosman, Fred, Seelentag, Walter, Stehle, Jean-Christophe, Yan, Pu   +4 more
core  

Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma

Biomedical Reports, 2015
Maintenance of telomere length is a critical hallmark of malignant transformation. While silenced in somatic cells, telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase, is frequently overexpressed in malignant cells thereby maintaining their telomere length.
Lindner, Sven, Bachmann, Hagen Sjard, Odersky, Andrea, Schaefers, Simon, Klein-Hitpaß, Ludger, Hero, Barbara, Fischer, Matthias, Eggert, Angelika, Schramm, Alexander, Schulte, Johannes   +9 more
openaire   +4 more sources

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

Aging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou, Gabor Liposits, Bara Barakat, Nam P. Nguyen   +3 more
wiley   +1 more source

Optimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,
Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu   +7 more
wiley   +1 more source

Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells

Scientific Reports, 2017
Cisplatin is one of the most efficacious antimitotic drugs used in the treatment of a range of malignant tumors. However, treatment failures are common due to the development of chemoresistance.
Zhengpei Zhang, Ling Yu, Guo Dai, Kezhou Xia, Gaiwei Liu, Qi Song, Chunjie Tao, Tian Gao, Weichun Guo   +8 more
doaj   +1 more source

The Regulation and Function of Hippo/YAP Pathway in Cancer

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh, Ruchi Kakar, Seline Torkamboor, Yue Sun   +3 more
wiley   +1 more source

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Nature Communications, 2017
Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse ...
Jun Fang, Jinping Jia, Matthew Makowski, Mai Xu, Zhaoming Wang, Tongwu Zhang, Jason W. Hoskins, Jiyeon Choi, Younghun Han, Mingfeng Zhang, Janelle Thomas, Michael Kovacs, Irene Collins, Marta Dzyadyk, Abbey Thompson, Maura O'Neill, Sudipto Das, Qi Lan, Roelof Koster, PanScan Consortium, TRICL Consortium, GenoMEL Consortium, Rachael S. Stolzenberg-Solomon, Peter Kraft, Brian M. Wolpin, Pascal W. T. C. Jansen, Sara Olson, Katherine A. McGlynn, Peter A. Kanetsky, Nilanjan Chatterjee, Jennifer H. Barrett, Alison M. Dunning, John C. Taylor, Julia A. Newton-Bishop, D. Timothy Bishop, Thorkell Andresson, Gloria M. Petersen, Christopher I. Amos, Mark M. Iles, Katherine L. Nathanson, Maria Teresa Landi, Michiel Vermeulen, Kevin M. Brown, Laufey T. Amundadottir   +43 more
doaj   +1 more source