Results 221 to 230 of about 85,495 (318)

HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment [PDF]

, 2013
Dennis Kappei, Falk Butter, Christian Benda, Marion Scheibe, Irena Drašković, Michelle Stevense, Clara Lopes Novo, Claire Basquin, Masatake Araki, Kimi Araki, Dragomir B. Krastev, Ralf Kittler, Rolf Jessberger, Arturo Londoño‐Vallejo, Matthias Mann, Frank Buchholz   +15 more
openalex   +1 more source

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells. [PDF]

Nat Cell Biol
Markiewicz-Potoczny M, Lee SY, Chatterjee S, Mabin JW, Zinsser A, Sandhu R, Tricola G, Hogg JR, Lazzerini Denchi E.   +8 more
europepmc   +1 more source

Long‐Term Stress Adaptation as a Highly‐Conserved Key Factor in Yeast Aging

Aging Cell, Volume 25, Issue 5, May 2026.
This study shows that long‐term, but not short‐term, stress exposure triggers molecular changes in yeast that mirror established hallmarks of aging, including altered proteostasis, epigenetic shifts, and reduced lifespan. These changes are reversible upon stress removal, and the genes involved are conserved across all domains of life. ABSTRACT Aging is
Yanzhuo Kong, Damola Adejoro, Christopher Winefield, Stephen L. W. On, Philip A. Wescombe, Arvind Subbaraj, Andrew Saunders, Venkata Chelikani   +7 more
wiley   +1 more source

Type 2 Diabetes From the Perspective of Telomere Biology. [PDF]

Endocrinol Diabetes Metab
Cao H, Feng H, Shen Z, Huang Y.
europepmc   +1 more source

Review on Human Telomere-binding Proteins of CST Components

, 2014
Luo Yunma
openalex   +1 more source

Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1

, 2006
K. Hansen
openalex   +1 more source

SIRT1 Downregulation by Advanced Glycation End Products Activates RANKL‐Dependent Osteoclast Signaling and Drives Chondrocyte Senescence During Osteoarthritis Development

Aging Cell, Volume 25, Issue 5, May 2026.
Mechanistic study of AGEs‐induced OA progression via SIRT1/RANKL/RANK signaling‐mediated osteoclast–chondrocyte communication and cellular senescence. ABSTRACT Advanced glycation end products (AGEs) accumulate with aging and metabolic stress and are increasingly implicated in osteoarthritis (OA) pathology.
Yizhou Li, Jian Wu, Rui Liu, Qiang Li, Fei Xue   +4 more
wiley   +1 more source

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

Aging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou, Gabor Liposits, Bara Barakat, Nam P. Nguyen   +3 more
wiley   +1 more source

Tankyrases and Their Binding Proteins: Origins of Their Roles in Diverse Cellular Pathways. [PDF]

Cells
Chalabi Hagkarim N, Grand RJ.
europepmc   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source