FPR2 activation mediates NOX‐dependent LAT1 expression and, in turn, promotes mTORC1 signaling. Upon stimulation with WKYMVm, the FPR2‐NOX2‐ROS axis upregulates LAT1 via increased c‐Myc phosphorylation and decreased miR‐126. Additionally, it promotes CD98 translocation to the plasma membrane.
Myrhiam Cassese +5 more
wiley +1 more source
Rare genetic diseases associated with G-quadruplex-induced replication stress. [PDF]
Herr LM +6 more
europepmc +1 more source
The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylation [PDF]
Shun‐Fu Tseng +2 more
openalex +1 more source
Signatures of Radiation‐Induced Stress and Putative Selection on Immune Targets in Chornobyl Wolves
ABSTRACT Investigating the physiological and evolutionary consequences of contaminant exposure in wild populations is critical for understanding long‐term ecological impacts of anthropogenic change. However, how and why species persist, even thrive, in highly contaminated regions in the absence of humans remains a topic of much debate.
Cara N. Love +9 more
wiley +1 more source
Defining the chromatin-associated protein landscapes on <i>Trypanosoma brucei</i> repetitive elements using synthetic TALE proteins. [PDF]
Carloni R +7 more
europepmc +1 more source
Summary Triticum turgidum cv Kronos is a tetraploid wheat cultivar that underpins one of the most widely used community platforms for functional genomics. Over the past decade, researchers have generated c. 3000 exome‐capture (EC) and promoter‐capture (PC) datasets linked to mutagenized seed stocks, along with extensive transcriptomic and phenotypic ...
Kyungyong Seong +9 more
wiley +1 more source
Arsenic trioxide allosterically inhibits human telomerase, validated by in-silico and in-vitro cancer and non cancer cell lines. [PDF]
Chaudhary A +8 more
europepmc +1 more source
Recombination suppression in plant adaptation and speciation
Summary Recombination suppression is increasingly recognized as an important facilitator of genomic divergence and speciation, especially under ongoing gene flow. In plants, however, the broader evolutionary consequences and the mechanisms by which recombination suppression arises and spreads are still incompletely understood, reflecting the inherent ...
Xu Zhang +4 more
wiley +1 more source
Whole exome sequencing identified two novel mutations of <i>ACD</i> in Chinese patients with idiopathic pulmonary fibrosis. [PDF]
Cao GH +5 more
europepmc +1 more source
Telomere-binding protein regulates the chromosome ends through the interaction with histone deacetylases in Arabidopsis thaliana. [PDF]
Lee WK, Cho MH.
europepmc +1 more source

