Results 91 to 100 of about 110,609 (302)

A marker of biological ageing predicts adult risk preference in European starlings, Sturnus vulgaris [PDF]

, 2018
Why are some individuals more prone to gamble than others? Animals often show preferences between 2 foraging options with the same mean reward but different degrees of variability in the reward, and such risk preferences vary between individuals ...
Andrews, Clare, Bateson, Melissa, Bedford, Tom, Monaghan, Pat, Nettle, Daniel, Reichert, Sophie   +5 more
core   +3 more sources

Telomere Length in the Newborn [PDF]

Pediatric Research, 2002
Telomere length is similar in different organs of the human fetus but variable among fetuses. During extrauterine life telomere length is highly variable among individuals and longer in women than men. In the present work we addressed the following questions: 1) Are there sex-related differences in telomere length at birth?
Koji, Okuda, Arlene, Bardeguez, Jeffrey P, Gardner, Paulette, Rodriguez, Vijaya, Ganesh, Masayuki, Kimura, Joan, Skurnick, Girgis, Awad, Abraham, Aviv   +8 more
openaire   +2 more sources

Advancing Precision Nutrition Through Multimodal Data and Artificial Intelligence

Advanced Science, EarlyView.
Individual responses to food vary dramatically, challenging traditional dietary advice. This review explores how the unique genetic makeup, gut microbiome, and brain activity shape host metabolic health. We examine how artificial intelligence integrates these multimodal data to predict individualized dietary needs, moving beyond one‐size‐fits‐all ...
Yuanqing Fu, Ke Zhang, Zelei Miao, Gaoyi Yang, Yujing Huang, Ju‐Sheng Zheng   +5 more
wiley   +1 more source

Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study

EBioMedicine, 2015
Background: The telomeric 3′-overhang (G-tail) length is essential for the biological effects of telomere dysfunction in vitro, but the association of length with aging and cardiovascular risk is unclear in humans. We investigated the association between
Tomohisa Nezu, Naohisa Hosomi, Tetsuya Takahashi, Kumiko Anno, Shiro Aoki, Akira Shimamoto, Hirofumi Maruyama, Tomonori Hayashi, Masayasu Matsumoto, Hidetoshi Tahara   +9 more
doaj   +1 more source

Gravidity is not associated with telomere length in a biracial cohort of middle-aged women: The Coronary Artery Risk Development in Young Adults (CARDIA) study. [PDF]

PLoS ONE, 2017
OBJECTIVE:Having experienced 2-3 births is associated with reduced mortality versus women with
Abbi D Lane-Cordova, Eli Puterman, Erica P Gunderson, Cheeling Chan, Lifang Hou, Mercedes Carnethon   +5 more
doaj   +1 more source

Is socioeconomic status associated with biological aging as measured by telomere length? [PDF]

, 2012
It has been hypothesized that one way in which lower socioeconomic status (SES) affects health is by increasing the rate of biological aging. A widely used marker of biological aging is telomere length. Telomeres are structures at the ends of chromosomes
Adams, Adams, Adler, Aubert, Begg, Blasco, C. Fenton, Carrero, Cawthon, Chan, Cherkas, Diez Roux, Dow, Duncan, Epel, Farzaneh-Far, Fournier, G. D. Batty, G. Der, Galobardes, Galobardes, Geronimus, Harris, Harris, Kananen, Lee, Lorant, M. Benzeval, Mackenbach, Mather, Mirabello, Moher, Nettleton, O'Donovan, Ogilvie, Olovnikov, P. G. Shiels, Pazol, Risques, Roux, Steptoe, T. Robertson, von Zglinicki, von Zglinicki, Wolkowitz, Yaffe, Zheng   +46 more
core   +3 more sources

Telomere length and cardiovascular disease

Archives of Cardiovascular Diseases, 2010
Telomeres are structures composed of deoxyribonucleic acid repeats that protect the end of chromosomes, but shorten with each cell division. They have been the subject of many studies, particularly in the field of oncology, and more recently their role in the onset, development and prognosis of cardiovascular disease has generated considerable interest.
Saliques, Sébastien, Zeller, Marianne, Lorin, Julie, Lorgis, Luc, Teyssier, Jean-Raymond, Cottin, Yves, Rochette, Luc, Vergely, Catherine   +7 more
openaire   +2 more sources

Telomere length in myelodysplastic syndromes [PDF]

Leukemia & Lymphoma, 2011
The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes (MDS) remains unclear. We compared peripheral blood leukocyte (PBL) TL among cases of histologically confirmed MDS (n = 65) who were treatment-naive with no prior cancer history to age-matched controls (n = 63).
Dana E, Rollison, P K, Epling-Burnette, Jong Y, Park, Ji-Hyun, Lee, Hyun, Park, Kristen, Jonathan, Ashley L, Cole, Jeffrey S, Painter, Mayenha, Guerrier, Johana, Meléndez-Santiago, William, Fulp, Rami, Komrokji, Jeffrey, Lancet, Alan F, List   +13 more
openaire   +2 more sources

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

Extreme Kinetic Stability and RNase Resistance of Human Telomerase RNA G‐Quadruplexes Overcome by DHX36 Helicase

Advanced Science, EarlyView.
The RNA G‐quadruplexes formed at the 5'‐end of the RNA component of human telomerase possess extreme slow unfolding rate, rendering them resistant to nuclease degradation. The helicase DHX36 overcame this kinetic barrier and significantly reduced the folded fraction.
Qun Luo, Yashuo Zhang, Yingxian Qian, Huiying Zhan, Wenqiang Wu, Huijuan You   +5 more
wiley   +1 more source