Results 101 to 110 of about 62,113 (243)

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

Identifying resistance‐conferring cytochrome P450s in weeds: experimental strategies and practical considerations

Pest Management Science, EarlyView.
Identifying resistance‐conferring cytochrome P450s requires integrating weed characterization, gene discovery and functional validation. No single approach is sufficient to distinguish causal resistance genes from herbicide‐metabolizing enzymes. Abstract Cytochrome P450 monooxygenases (P450s) play a pivotal role in metabolic herbicide resistance, yet ...
Satoshi Iwakami, Takuya Yamaguchi
wiley   +1 more source

How We Simulate Nanopores

Small Methods, EarlyView.
Nanopore technology has revolutionized single‐molecule sensing, yet it suffers from an inherent interpretive challenge. Molecular dynamics has emerged as a go‐to method for determining the relationship between the structure of translocating molecules and the nanopore current signals.
Behzad Mehrafrooz, Xavier Mleziva, Meng Xu, Melika Shekari, Christopher Maffeo, Aleksei Aksimentiev   +5 more
wiley   +1 more source

Telomere length in sleep disorders

Experimental Gerontology
Sleep and circadian rhythms are affected by aging. Although the relationship between sleep disorders and cellular aging has been demonstrated in some studies, it still remains unclear. Telomere length has been considered one of the sensitive biomarkers for aging in recent years.
OLGUNER EKER, ÖZLEM, ASDEMİR, AKİF, DÜNDAR, MUNİS, İSMAİLOĞULLARI, SEVDA, AMRALIYEV, AYAZ, BİÇER, ELİF ÖZGE, EŞEL, ERTUĞRUL, Badur Mermer, Damla, Eşel, Gülüstan   +8 more
openaire   +3 more sources

Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus

Yeast, EarlyView.
Yeasts and related fungi isolated from cacti or nearby non‐cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host. ABSTRACT Together with other fungi, yeasts make up a significant component of the plant microbiome. As the planet warms, cacti expand their range.
Alya N. Hussain, Kevin T. Fotso, Michael A. McMurray   +2 more
wiley   +1 more source

Living Low and Dry: Costs of and Resilience to Soil Hydric Stress in a Fossorial Amphisbaenian Reptile

Integrative Zoology, EarlyView.
Soil drought imposes moderate, temporary costs on a strictly fossorial amphisbaenian reptile. However, these animals seem to cope with, at least, moderately short droughts thanks to their peculiar adaptations to living in an underground environment. ABSTRACT The physiological traits of animals can be strongly influenced by climatic fluctuations, and ...
José Martín, Álvaro Navarro‐Castilla, Alejandro de la Concha, José Javier Cuervo, Isabel Barja, Pilar López   +5 more
wiley   +1 more source

Chromosome‐Level Genome Assemblies of Two Softshell Turtles with ZZ/ZW Provide Insights into TE‐Driven Recombination Suppression in Sex Chromosomes

Integrative Zoology, EarlyView.
This study presents the first genomic identification and characterization of ZW sex chromosomes in two soft‐shelled turtle species through genome assembly and resequencing. We reveal the structural organization of ZW chromosomes, identifying both pseudoautosomal regions (PARs) and differentiated regions.
Jianjun Liu, Zhiyuan Yang, Min Tang, Tingting Chen, Siqi Liu, Ziyao Meng, Xingjiang Bu, Xingquan Xia, Guang Yang, Liuwang Nie   +9 more
wiley   +1 more source

Early‐Life Telomere Length Negatively Covaries With Brood Size and Father Age, and Predicts Long‐Term Survival in Male Barn Swallows (Hirundo rustica)

Integrative Zoology, EarlyView.
In barn swallows, nestlings raised in larger broods or by older social fathers have shorter telomeres, and those with longer telomeres tend to live longer, suggesting that early‐life conditions may shape individual lifespan through telomere dynamics. ABSTRACT Parental decisions on breeding, such as brood size and timing of reproduction, influence the ...
Andrea Novelli, Manuela Caprioli, Roberto Ambrosini, Alessandra Costanzo, Diego Rubolini, Marco Parolini, Andrea Romano   +6 more
wiley   +1 more source

Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma

Allergy, EarlyView.
This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez, Sara Vázquez‐Mera, Laura Martelo‐Vidal, Marina Blanco Aparicio, Uxío Calvo Álvarez, Coral González Fernández, Mar Mosteiro Añón, Dolores Corbacho Abelaira, Tamara Hermida Valverde, Christian Calvo Henríquez, Susana B. Bravo, Lena Uller, Juan J. Nieto‐Fontarigo, Francisco J. Salgado, Francisco J. González‐Barcala   +14 more
wiley   +1 more source

Insight into telomere regulation: road to discovery and intervention in plasma drug-protein targets

BMC Genomics
Background Telomere length is a critical metric linked to aging, health, and disease. Currently, the exploration of target proteins related to telomere length is usually limited to the context of aging and specific diseases, which limits the discovery of
Kaixi Ding, Juejue Zhangwang, Ming Lei, Chunping Xiong   +3 more
doaj   +1 more source