Results 91 to 100 of about 59,573 (233)

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Longer prostate stromal cell telomere length is associated with increased risk of death from other cancers

Frontiers in Medicine
BackgroundTelomeres are located at chromosomal termini and function to maintain genomic integrity. Telomere dysfunction is a well-recognized contributor to aging and age-related diseases, such as prostate cancer. Since telomere length is highly heritable,
Joakin O. Mori, Elizabeth A. Platz, Elizabeth A. Platz, Elizabeth A. Platz, Jiayun Lu, Jiayun Lu, Alexandria Brame, Misop Han, Misop Han, Corinne E. Joshu, Corinne E. Joshu, Angelo M. De Marzo, Angelo M. De Marzo, Angelo M. De Marzo, Alan K. Meeker, Alan K. Meeker, Alan K. Meeker, Christopher M. Heaphy, Christopher M. Heaphy   +18 more
doaj   +1 more source

Living Low and Dry: Costs of and Resilience to Soil Hydric Stress in a Fossorial Amphisbaenian Reptile

Integrative Zoology, EarlyView.
Soil drought imposes moderate, temporary costs on a strictly fossorial amphisbaenian reptile. However, these animals seem to cope with, at least, moderately short droughts thanks to their peculiar adaptations to living in an underground environment. ABSTRACT The physiological traits of animals can be strongly influenced by climatic fluctuations, and ...
José Martín, Álvaro Navarro‐Castilla, Alejandro de la Concha, José Javier Cuervo, Isabel Barja, Pilar López   +5 more
wiley   +1 more source

Chromosome‐Level Genome Assemblies of Two Softshell Turtles with ZZ/ZW Provide Insights into TE‐Driven Recombination Suppression in Sex Chromosomes

Integrative Zoology, EarlyView.
This study presents the first genomic identification and characterization of ZW sex chromosomes in two soft‐shelled turtle species through genome assembly and resequencing. We reveal the structural organization of ZW chromosomes, identifying both pseudoautosomal regions (PARs) and differentiated regions.
Jianjun Liu, Zhiyuan Yang, Min Tang, Tingting Chen, Siqi Liu, Ziyao Meng, Xingjiang Bu, Xingquan Xia, Guang Yang, Liuwang Nie   +9 more
wiley   +1 more source

Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy

Andrology, EarlyView.
ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby, Sylvianne Hennebicq, Jacqueline Saias, Florence Brugnon, Isabelle Berthaut, Myriam Daudin, Louis Bujan, Ludovic Dumont, Christine Rondanino, Aurélie Feraille, Nathalie Rives   +10 more
wiley   +1 more source

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky, Kristian Almstrup, Svetlana Cherlin, Victoria K. Cortessis, Alberto Ferlin, Jourik A. Gietema, Anna González‐Neira, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Lambertus A. Kiemeney, Jung Kim, Csilla Krausz, Davor Lessel, Ragnhild A. Lothe, Kevin T. Nead, Jérémie Nsengimana, Jenny N. Poynter, Ewa Rajpert‐DeMeyts, Lorenzo Richiardi, Stephen M. Schwartz, Rolf I. Skotheim, Douglas R. Stewart, Clare Turnbull, Fredrik Wiklund, Tongzhang Zheng, Katherine L. Nathanson, Katherine A. McGlynn, for the Testicular Cancer Consortium   +28 more
wiley   +1 more source

Association between modifiable lifestyle factors and telomere length: a univariable and multivariable Mendelian randomization study

Journal of Translational Medicine
Background Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservation; however, the association ...
Miao Chen, Zhen Wang, Hongfei Xu, Peng Teng, Weidong Li, Liang Ma   +5 more
doaj   +1 more source

Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms

British Journal of Pharmacology, EarlyView.
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl, Jakub Morze, Sabina Wallerer, Georg Hoffmann   +3 more
wiley   +1 more source

A Proposed Clinical Diagnostic Framework for Short Telomere Syndrome

Clinical Genetics, EarlyView.
We propose a phenotype‐based diagnostic framework for short telomere syndrome that integrates age‐adjusted telomere length, phenotypic manifestations, and genetic findings, where available. The framework is intended to guide clinical evaluation, longitudinal surveillance, and individualized management while acknowledging limitations in current telomere
Andrew Courtwright, Richard A. King, Jennie Vagher, Cate T. Levy, Juan Gallegos F. Orozco, Luis FZ Batista, Afaf Osman, Srinivas Tantavahi, Mary Beth Scholand   +8 more
wiley   +1 more source

Age‐specific melanoma risk associated with nevi: a pooled analysis from the M‐SKIP project

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Objective This study investigates the association of melanoma risk with total‐body nevus count and the presence of atypical nevi in younger (< 40 years) and older (> 60 years) individuals. Methods A pooled analysis was conducted within the M‐SKIP project, based on multiple melanoma case‐control studies.
Giulia Doi, Aurora Gaeta, Simone Ribero, Nelleke Gruis, Julia Newton‐Bishop, David Polsky, DeAnn Lazovich, Paola Ghiorzo, Gloria Ribas, Chiara Menin, Alexander J. Stratigos, Gabriella Guida, Susana Puig, Maria Concetta Fargnoli, Peter A. Kanetsky, Paola Queirolo, Vincenzo Bagnardi, Veronique Bataille, Sara Raimondi, Sara Gandini, M‐SKIP study group   +20 more
wiley   +1 more source