Results 91 to 100 of about 62,113 (243)

Longer prostate stromal cell telomere length is associated with increased risk of death from other cancers

Frontiers in Medicine
BackgroundTelomeres are located at chromosomal termini and function to maintain genomic integrity. Telomere dysfunction is a well-recognized contributor to aging and age-related diseases, such as prostate cancer. Since telomere length is highly heritable,
Joakin O. Mori, Elizabeth A. Platz, Elizabeth A. Platz, Elizabeth A. Platz, Jiayun Lu, Jiayun Lu, Alexandria Brame, Misop Han, Misop Han, Corinne E. Joshu, Corinne E. Joshu, Angelo M. De Marzo, Angelo M. De Marzo, Angelo M. De Marzo, Alan K. Meeker, Alan K. Meeker, Alan K. Meeker, Christopher M. Heaphy, Christopher M. Heaphy   +18 more
doaj   +1 more source

Mediterranean diet and telomere length

BMJ, 2014
Genetic factors may contribute to the link between Mediterranean diet and longer telomeres Interest in telomere biology has increased in recent years, both because of the quest for a reliable marker of biological ageing and because shorter telomeres in leucocytes have been shown to predict coronary heart disease (CHD).1 2 The methodological challenges
openaire   +3 more sources

Telomere length in atherosclerosis and diabetes

Atherosclerosis, 2010
The Nobel Prize in Medicine in 2009 was awarded to Elizabeth Blackburn, Carol Greider and Jack Szostak for discovering the molecular structure of the far ends of chromosomes, called telomeres (Fig. 1), and how these protect chromosomes from degradation.
Salpea, Klelia D., Humphries, Steve E.
openaire   +2 more sources

Sex‐Specific Early Life Corticosterone Stress‐Coping Capacity Is Linked to Mitochondrial Content and Telomere Maintenance

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Glucocorticoids are upregulated during acute challenges, contributing to maintenance of energy balance. However, if this upregulation exceeds a threshold or becomes chronic, it can lead to harmful effects. Investigating the factors behind between‐individual variation in the magnitude of the response to acute stress and how effectively ...
Mauricio Guillen‐Parra, Alberto Velando, Bibiana Montoya, Roxana Torres   +3 more
wiley   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

Nature Communications
The ends of human chromosomes are capped by specialized nucleoprotein structures, termed telomeres, which are essential for genome stability. Recent advances in long-read sequencing have enabled allele-specific telomere length measurements at nucleotide ...
Xiaoran Chai, LaiFong Poon, Hengrui Liu, Manvendra K. Singh, Takashi Minami, Goro Sashida, Masafumi Fukuda, Bin Tean Teh, Patrick Tan, William Ying Khee Hwang, Jue Lin, Angela S. Koh, Tatsuro Kondoh, Lifeng Xu, Motomi Osato, Jin Liu, Shang Li   +16 more
doaj   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Association between modifiable lifestyle factors and telomere length: a univariable and multivariable Mendelian randomization study

Journal of Translational Medicine
Background Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservation; however, the association ...
Miao Chen, Zhen Wang, Hongfei Xu, Peng Teng, Weidong Li, Liang Ma   +5 more
doaj   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source