Results 91 to 100 of about 2,052,365 (293)

Gravidity is not associated with telomere length in a biracial cohort of middle-aged women: The Coronary Artery Risk Development in Young Adults (CARDIA) study. [PDF]

PLoS ONE, 2017
OBJECTIVE:Having experienced 2-3 births is associated with reduced mortality versus women with
Abbi D Lane-Cordova, Eli Puterman, Erica P Gunderson, Cheeling Chan, Lifang Hou, Mercedes Carnethon   +5 more
doaj   +1 more source

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]

, 2012
© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Marija Guc-Scekic, Juan P Trujillo, Maja Zivkovic, Gordana Joksic, Predrag Slijepcevic, Slijepcevic, P, Trujillo, JP, Petrovic, S, Zivkovic, Maja, Joksic, I, Trujillo Quintero, Juan Pablo, Joksic, G, Jordi Surralles, Aleksandra Stankovic, Vujic, D, Zivkovic, M, Vujic, Dragana, Joksic, Gordana, Andreja Leskovac, Joksic, Ivana, Surralles, J, Guc-Scekic, Marija, Maryam Ojani, Ojani, M, Ojani, Maryam, Dragana Vujic, Slijepcevic, Pedrag, Petrovic, Sandra, Sandra Petrovic, Guc-Scekic, M, Stankovic, A, Stankovic, Aleksandra, Leskovac, Andreja, Ivana Joksic, Leskovac, A, Surralles, Jordi   +35 more
core   +1 more source

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. [PDF]

PLoS ONE, 2012
Telomeres, specialised structures that protect chromosome ends, play a critical role in preserving chromosome integrity. Telomere dynamics in the Tasmanian devil (Sarcophilus harrisii) are of particular interest in light of the emergence of devil facial ...
Hannah S Bender, Elizabeth P Murchison, Hilda A Pickett, Janine E Deakin, Margaret A Strong, Carly Conlan, Daniel A McMillan, Axel A Neumann, Carol W Greider, Gregory J Hannon, Roger R Reddel, Jennifer A Marshall Graves   +11 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Cell cycle-dependent modification of Pot1 and its effects on telomere function [PDF]

, 2009
Telomere functions are tightly controlled throughout the cell cycle to allow telomerase access while suppressing a bona fide DNA damage response (DDR) at linear chromosome ends.
Kuznetsov, V, Kuznetsov, V.
core  

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

ESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli, François Roubille, Nicolas Meyer, Giulio Pompilio, Lionel Leroux, Philippe Henon, Guillaume Trebuchet, Anthony Criquet, Matthieu de Kalbermatten, Eric Saloux, Alain Manrique, Pierre‐Yves Marie, Deepak L. Bhatt, Scott D. Solomon, Gilles Montalescot, David E. Newby, Faiez Zannad, on behalf of the EXCELLENT Trial Investigators   +17 more
wiley   +1 more source

Illuminating point‐of‐care diagnostics with aggregation‐induced emission biosensors

FlexMat, EarlyView.
This review highlights the application of aggregation‐induced emission luminogens (AIEgens) in point‐of‐care (POC) diagnostics for disease biomarker detection. It systematically examines a range of biosensing platforms, including lateral flow immunoassays, microfluidic chips, and electrochemiluminescence sensors, alongside their utility in detecting ...
Danni Hu, Yubing Hu, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source

Correlation between telomere shortening in maternal peripheral blood and fetal aneuploidy

BMC Pregnancy and Childbirth
Background This study aimed to assess whether maternal telomere length is a more accurate predictor of trisomy 21 than maternal age while also exploring the factors influencing maternal and fetal telomere length.
Xiao-Xi Zhao, Le Le Bai
doaj   +1 more source

Telomere Length Correlates with Life Span of Dog Breeds

Cell Reports, 2012
Telomeric DNA repeats are lost as normal somatic cells replicate. When telomeres reach a critically short length, a DNA damage signal is initiated, inducing cell senescence.
Laura J. Fick, Gordon H. Fick, Zichen Li, Eric Cao, Bo Bao, Doug Heffelfinger, Heidi G. Parker, Elaine A. Ostrander, Karl Riabowol   +8 more
doaj   +1 more source