Results 101 to 110 of about 110,609 (302)

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

Testing three hypotheses about effects of sensitive-insensitive parenting on telomeres. [PDF]

, 2020
Telomeres are the protective DNA-protein sequences appearing at the ends of chromosomes; they shorten with each cell division and are considered a biomarker of aging.
Beijers, Roseriet, Belsky, Jay, de Weerth, Carolina, Hartman, Sarah, Hastings, Waylon, Mattern, Brooke C, Shalev, Idan   +6 more
core   +1 more source

AI Powered Biobanks From Static Archives to Dynamic Discovery Engines

Advanced Intelligent Discovery, EarlyView.
Large language models (LLMs) provide a potential framework for transforming biobanks from static data repositories into intelligent discovery engines. By enabling unified representation and analysis of multimodal biomedical data, LLM‐based systems facilitate dynamic risk prediction, biomarker identification, and mechanistic interpretation, thereby ...
Wenzhen Yin, Yutian Feng, Wenrui Ma, Yuxin Su, Li Min, Juan Liu   +5 more
wiley   +1 more source

The effect on melanoma risk of genes previously associated with telomere length. [PDF]

, 2014
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case ...
Akslen, L.A., AMFS Investigators, Amos, C.I., Andresen, P.A., Avril, M.F., Azizi, E., Barrett, J.H., Bishop, D.T., Bishop, J.A.N., Brossard, M., Brown, K.M., Cust, A.E., Debniak, T., Demenais, F., Doorn, R. van, Dunning, A.M., Elder, D.E., Friedman, E., GenoMEL Consortium, Ghiorzo, P., Gillanders, E.M., Goldstein, A.M., Gruis, N.A., Hansson, J., Harland, M., Hayward, N.K., Helsing, P., Hocevar, M., Hoiom, V., IBD Investigators, Iles, M.M., Ingvar, C., Kanetsky, P.A., Landi, M.T., Lang, J., Lathrop, G.M., Law, M.H., Lee, J.E., Lubinski, J., MacGregor, S., Mackie, R.M., Mann, G.J., Martin, N.G., Molven, A., Montgomery, G.W., Moses, E.K., Novakovic, S., Olsson, H., Pharoah, P.D.P., Pooley, K.A., Puig, S., Puig-Butille, J.A., QMEGA Investigator, QTWIN Investigator, Radford-Smith, G.L., Randerson-Moor, J., Scarra, G.B., SDH Study Grp, Stoep, N. van der, Taylor, J.C., Ward, S.V., Whiteman, D.C.   +61 more
core   +4 more sources

Biodegradable and Bioinspired UV Light Recognition via Sustainable Synaptic Transistors for Artificial Intelligence Vision Systems

Advanced Intelligent Systems, EarlyView.
We report a biodegradable electrolyte‐gated synaptic phototransistor that combines low‐power UV sensing with memory functionality, offering a sustainable platform for AI vision systems and health‐monitoring technologies. Presented here is a biodegradable, bioinspired synaptic phototransistor (SPT) based on an electrolyte‐gated field‐effect transistor ...
Theodoros Serghiou, Rogério Morais, Douglas Henrique Vieira, Neri Alves, Roghaieh Parvizi, Jeff Kettle   +5 more
wiley   +1 more source

Correlation between telomere shortening in maternal peripheral blood and fetal aneuploidy

BMC Pregnancy and Childbirth
Background This study aimed to assess whether maternal telomere length is a more accurate predictor of trisomy 21 than maternal age while also exploring the factors influencing maternal and fetal telomere length.
Xiao-Xi Zhao, Le Le Bai
doaj   +1 more source

Telomere Length Correlates with Life Span of Dog Breeds

Cell Reports, 2012
Telomeric DNA repeats are lost as normal somatic cells replicate. When telomeres reach a critically short length, a DNA damage signal is initiated, inducing cell senescence.
Laura J. Fick, Gordon H. Fick, Zichen Li, Eric Cao, Bo Bao, Doug Heffelfinger, Heidi G. Parker, Elaine A. Ostrander, Karl Riabowol   +8 more
doaj   +1 more source

The Effect of Physical Activity agains the Telomere Length in the Leukocytes Cells of KONI Athletes

Biosaintifika: Journal of Biology & Biology Education, 2017
Telomeres are strands of non coding DNA at the ends of chromosomes that have the primary function to protect DNA from damage and maintain chromosomal stability.
Endang Purwaningsih, Titiek Djannatun, Etty Widayanti, Yulia Suciati, Yenni Zulhamidah   +4 more
doaj   +1 more source

Telomere length reveals cumulative individual and transgenerational inbreeding effects in a passerine bird [PDF]

, 2016
Inbreeding results in more homozygous offspring that should suffer reduced fitness, but it can be difficult to quantify these costs for several reasons. First, inbreeding depression may vary with ecological or physiological stress and only be detectable ...
Alho, Annavi, Armario, Armbruster, Asghar, Auld, Balaban, Balloux, Barrett, Barrett, Bauch, Becker, Blackburn, Bleakley, Boonekamp, Brekke, Brouwer, Brouwer, Chapman, Coltman, Constantini, David, Eikenaar, Epel, Finkel, García-Navas, Griffiths, Grueber, Hadfield, Hall, Hammers, Hansson, Harrison, Heidinger, Hemann, Huisman, Kalinowski, Kardos, Keane, Keller, Keller, Keller, Kennedy, Ketola, Komdeur, Komdeur, Komdeur, Kristensen, Lacy, Manning, Marr, Massudi, Miller, Nemoto, Norman, Patrick, Pfaffl, R Core Team, Reid, Richardson, Richardson, Rodríguez-Quilón, Schwabl, Sharp, Sheridan, Simmons, Simons, Slate, Spurgin, Symonds, Teska, Ujvari, Van De Crommenacker, Walling, Wang, Wetzel, Zglinicki, Zglinicki   +77 more
core   +4 more sources

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source