Results 171 to 180 of about 57,502 (259)

Telomere Length and Mitochondrial Copy Number as Potential Biomarkers for Male Infertility in Iraqi Men. [PDF]

Genes (Basel)
Kadhim MF, Samawi FT, Gargouri A.
europepmc   +1 more source

A Novel Human Cellular System for Studying Normal Aging and for Anti‐Aging Discovery

Aging Cell, Volume 25, Issue 2, February 2026.
This study introduces a human cellular aging model using placental trophoblasts (hTSC‐STBs) that mimics key aging features like senescence and genomic instability. It aligns with human tissue aging and responds to anti‐aging treatments, offering a scalable platform to screen potential therapies and bridge lab findings to clinical applications ...
Zhen Feng, Cheuk Shuen Li, Haifeng Fu, Wenxin Jiang, Weiyu Zhang, Yingzhang Huang, Yunying Huang, Timothy Theodore Ka Ki Tam, Yang Li, Fang Liu, Liming Lu, Yin Lau Lee, William Shu Biu Yeung, Gordon Dougan, Pentao Liu   +14 more
wiley   +1 more source

Astronauts as a Human Aging Model: Epigenetic Age Responses to Space Exposure

Aging Cell, Volume 25, Issue 2, February 2026.
This longitudinal analysis of Axiom‐2 astronauts reveals that spaceflight induces a rapid andsignificant epigenetic age acceleration that is largely reversible upon return to Earth. These findings identify space exposure as a unique model for studying aging mechanisms and potentially testing geroprotective interventions.
Matías Fuentealba, JangKeun Kim, Jeremy Wain Hirschberg, Bader Shirah, Eliah G. Overbey, Christopher Mason, David Furman   +6 more
wiley   +1 more source

Lengthened telomere length in peripheral blood leukocytes in patients with rheumatoid arthritis complicated with airway disease. [PDF]

BMC Rheumatol
Higuchi T, Oka S, Shimada K, Tsunoda S, Ito S, Fujimori M, Nakamura T, Suzuki M, Saisho K, Shinohara S, Matsui T, Migita K, Nagaoka S, Tohma S, Furukawa H.   +14 more
europepmc   +1 more source

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits

Aging Cell, Volume 25, Issue 2, February 2026.
Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen, Jennifer L. Martindale, Martina Rossi, Chang Hoon Shin, Apala Pal, Rachel Munk, Martin Salamini‐Montemurri, Mirko Baranzini, Ethan M. Arends, Maja Mustapic, Yuta Lee, Jau‐Nan Lee, Sicco H. Popma, Justin Hu, Nathan Duda, Carlos J. Nogueras‐Ortiz, Dimitrios Kapogiannis, Chang‐Yi Cui, Myriam Gorospe   +18 more
wiley   +1 more source

Infant buccal telomere length: associations with maternal distress in pregnancy and offspring temperament. [PDF]

Front Public Health
Soerensen AE, Van den Bergh BRH, Braeken MAKA, van den Heuvel MI, Martens DS, Vos S, Nawrot TS.   +6 more
europepmc   +1 more source

Hevin Promotes Aging‐Related Cardiac Dysfunction via Facilitating Cardiac Inflammation in Male Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Hevin released by iWAT into circulation stimulates cardiac macrophages through TLR4, inducing their polarization and CCL5 secretion, leading to worsened cardiac dysfunction and subsequent recruitment of additional inflammatory cells for pro‐inflammatory factor release.
Shi‐Yu Huang, Yu‐Jie Chen, Yu‐Xin Hu, Jia‐Chen Liu, Min Hu   +4 more
wiley   +1 more source

A systematic review on the association of metabolic syndrome with telomere length and telomerase activity. [PDF]

Bioinformation
Dash I, Behera BP, Gupta G, Dash OP, Sahu PK.   +4 more
europepmc   +1 more source

Sex Differences in Associations Between Adversity and Biological Ageing

Aging Cell, Volume 25, Issue 2, February 2026.
Childhood adversity was associated with older biological ageing profiles (metabolomic ageing, frailty, telomeres, grip strength) primarily in females, supported by sex‐stratified analyses. Adulthood adversity showed stronger associations in males, particularly for frailty and grip strength, with significant sex‐by‐adversity interactions, highlighting ...
Julian Mutz, Luca Di Benedetto, Thole H. Hoppen, Nexhmedin Morina, Monica Aas   +4 more
wiley   +1 more source