Results 201 to 210 of about 59,573 (233)
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Annual Review of Biochemistry, 1996
Telomeres are the components of chromosome ends that provide stability and allow the complete replication of the ends. Telomere length is maintained by a balance between processes that lengthen and those that shorten telomeres. Telomeraseis a ribonucleoprotein polymerase that specifically elongates telomeres.
Carol W Greider
exaly +3 more sources
Telomeres are the components of chromosome ends that provide stability and allow the complete replication of the ends. Telomere length is maintained by a balance between processes that lengthen and those that shorten telomeres. Telomeraseis a ribonucleoprotein polymerase that specifically elongates telomeres.
Carol W Greider
exaly +3 more sources
Telomere length in reproduction
Andrologia, 2012Telomeres, noncoding hexameric tandem repeats located at the ends of chromosomes, maintain chromosome stability and genome integrity. These guanine-rich repeats are highly conserved during evolution, and their role is dependent on their length and structure.
J, Thilagavathi, S, Venkatesh, R, Dada
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Acta Paediatrica, 2008
AbstractAim: To assess the telomere length in apparently healthy obese and normal‐weight subjects.Methods: Seventy‐six Caucasian subjects were chosen including 53 children (age 8.2 ± 3.5 years) and 23 adults (age 40.5 ± 8.4 years). Among these, 22 (12 children and 10 adults) were obese with a body mass index (BMI, kg/m2) > 2 SD above the norm ...
ZANNOLLI R. +6 more
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AbstractAim: To assess the telomere length in apparently healthy obese and normal‐weight subjects.Methods: Seventy‐six Caucasian subjects were chosen including 53 children (age 8.2 ± 3.5 years) and 23 adults (age 40.5 ± 8.4 years). Among these, 22 (12 children and 10 adults) were obese with a body mass index (BMI, kg/m2) > 2 SD above the norm ...
ZANNOLLI R. +6 more
openaire +5 more sources
2007
Most somatic cells of long-lived species undergo telomere shortening throughout life. Critically short telomeres trigger loss of cell viability in tissues, which has been related to alteration of tissue function and loss of regenerative capabilities in aging and aging-related diseases.
Andrés, Canela +2 more
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Most somatic cells of long-lived species undergo telomere shortening throughout life. Critically short telomeres trigger loss of cell viability in tissues, which has been related to alteration of tissue function and loss of regenerative capabilities in aging and aging-related diseases.
Andrés, Canela +2 more
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Interchromosomal Telomere Length Variation
Biochemical and Biophysical Research Communications, 2002Despite the recent discovery of interchromosomal telomere length variation, a role for heterogeneity in telomere maintenance has yet to be established. This study aimed to clarify relative telomere length differences between chromosomes. Combined chromosomal sorting and telomeric repeat content analysis in GM130B cells, the relative telomeric repeat ...
Takeshi, Suda +8 more
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Telomere Length in Elite Athletes
International Journal of Sports Physiology and Performance, 2017Growing evidence suggests that regular moderate-intensity physical activity is associated with an attenuation of leukocyte telomere length (LTL) shortening. However, more controversy exists regarding higher exercise loads such as those imposed by elite-sport participation.Methods:The authors investigated LTL differences between young elite athletes (n =
Muniesa Ferrero, Carlos Alberto +9 more
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Recombination in telomere-length maintenance
Trends in Biochemical Sciences, 2000Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion.
A, Kass-Eisler, C W, Greider
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Telomere length inheritance and aging
Mechanisms of Ageing and Development, 2008Telomere shortening accompanies human aging, and premature aging syndromes are often associated with short telomeres. These two observations are central to the hypothesis that telomere length directly influences longevity. If true, genetically determined mechanisms of telomere length homeostasis should significantly contribute to variations of ...
Dennis, Kappei +1 more
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Changes of telomere length with aging
Geriatrics & Gerontology International, 2010We reviewed our methodology and results of telomere measurements, with reference to telomere length and aging. Human tissues always showed telomere shortening with age, except for the brain and myocardium. Yearly rates of telomere length reduction in various tissues were mostly within the range 20–60 bp, and thus compatible with that expected from only
Kaiyo, Takubo +8 more
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Telomere length in Hepatitis C
Cancer Genetics and Cytogenetics, 2008Telomeres are nucleoprotein structures located at the termini of chromosomes that protect the chromosomes from fusion and degradation. Hepatocyte cell-cycle turnover may be a primary mechanism of telomere shortening in hepatitis C virus (HCV) infection, inducing fibrosis and cellular senescence. HCV infection has been recognized as potential cause of B-
Y, Kitay-Cohen +4 more
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