Results 211 to 220 of about 62,113 (243)
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Telomere length in reproduction
Andrologia, 2012Telomeres, noncoding hexameric tandem repeats located at the ends of chromosomes, maintain chromosome stability and genome integrity. These guanine-rich repeats are highly conserved during evolution, and their role is dependent on their length and structure.
J, Thilagavathi, S, Venkatesh, R, Dada
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2007
Most somatic cells of long-lived species undergo telomere shortening throughout life. Critically short telomeres trigger loss of cell viability in tissues, which has been related to alteration of tissue function and loss of regenerative capabilities in aging and aging-related diseases.
Andrés, Canela +2 more
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Most somatic cells of long-lived species undergo telomere shortening throughout life. Critically short telomeres trigger loss of cell viability in tissues, which has been related to alteration of tissue function and loss of regenerative capabilities in aging and aging-related diseases.
Andrés, Canela +2 more
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Telomere Length in Elite Athletes
International Journal of Sports Physiology and Performance, 2017Growing evidence suggests that regular moderate-intensity physical activity is associated with an attenuation of leukocyte telomere length (LTL) shortening. However, more controversy exists regarding higher exercise loads such as those imposed by elite-sport participation.Methods:The authors investigated LTL differences between young elite athletes (n =
Muniesa Ferrero, Carlos Alberto +9 more
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Recombination in telomere-length maintenance
Trends in Biochemical Sciences, 2000Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion.
A, Kass-Eisler, C W, Greider
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Telomere length and vitamin B12
2022Telomeres are non-coding nucleoprotein structures consisting of a highly conserved tandem repeat DNA sequence that caps the ends of chromosomes in eukaryotes. Telomeres confer chromosomal stability, protect the genome from nucleolytic degradation, avoid aberrant recombination and improper repair, and prevent random fusion of chromosomes.
Guruvaiah, Praveen +2 more
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Telomere Amount and Length Assay
Pharmaceutical Research, 2001Telomeres are specific DNA structure at the ends of chromosomes to protect chromosomes from fusion, recombination, and degradation. Telomere length changes are implicated in cell senescence, aging, tumorigenesis, and DNA repair. The standard method for measuring telomere length is Southern blot analysis.
Y, Gan +3 more
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Changes of telomere length with aging
Geriatrics & Gerontology International, 2010We reviewed our methodology and results of telomere measurements, with reference to telomere length and aging. Human tissues always showed telomere shortening with age, except for the brain and myocardium. Yearly rates of telomere length reduction in various tissues were mostly within the range 20–60 bp, and thus compatible with that expected from only
Kaiyo, Takubo +8 more
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Telomere length inheritance and aging
Mechanisms of Ageing and Development, 2008Telomere shortening accompanies human aging, and premature aging syndromes are often associated with short telomeres. These two observations are central to the hypothesis that telomere length directly influences longevity. If true, genetically determined mechanisms of telomere length homeostasis should significantly contribute to variations of ...
Dennis, Kappei +1 more
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Diet, nutrition and telomere length
The Journal of Nutritional Biochemistry, 2011The ends of human chromosomes are protected by DNA-protein complexes termed telomeres, which prevent the chromosomes from fusing with each other and from being recognized as a double-strand break by DNA repair proteins. Due to the incomplete replication of linear chromosomes by DNA polymerase, telomeric DNA shortens with repeated cell divisions until ...
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Haploinsufficiency and telomere length homeostasis
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012In humans, autosomal dominant or X-linked disease can arise through a phenomenon termed haploinsufficiency, where one remaining wild-type allele is insufficient for function. In model organisms, the impact of heterozygosity can be tested directly with engineered mutant alleles or in a hemizygous state where the expression of one allele is abrogated ...
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