Results 231 to 240 of about 68,105 (246)

Astronauts as a Human Aging Model: Epigenetic Age Responses to Space Exposure

Aging Cell, Volume 25, Issue 2, February 2026.
This longitudinal analysis of Axiom‐2 astronauts reveals that spaceflight induces a rapid andsignificant epigenetic age acceleration that is largely reversible upon return to Earth. These findings identify space exposure as a unique model for studying aging mechanisms and potentially testing geroprotective interventions.
Matías Fuentealba, JangKeun Kim, Jeremy Wain Hirschberg, Bader Shirah, Eliah G. Overbey, Christopher Mason, David Furman   +6 more
wiley   +1 more source

Subtelomeric elements provide stability to short telomeres in telomerase-negative cells of the budding yeast Naumovozyma castellii. [PDF]

Curr Genet
Jaiswal RK, Garibo Domingo T, Grunchec H, Singh K, Pirooznia M, Elhaik E, Cohn M.   +6 more
europepmc   +1 more source

Comparison of the effectiveness of Models 1, 2a and 2b in estimating fetal fraction (FF) based on telomere content.

Zuzana Holesova (15253816), Jaroslav Budis (837494), Marcel Kucharik (9306190), Juraj Gazdarica (4780389), Daria Carska (21702564), Gabriel Minarik (2512540), Michaela Hyblova (837491), Tomas Szemes (4780383)   +7 more
openalex   +1 more source

The Secretome of Human Trophoblast Stem Cells Attenuates Senescence‐Associated Traits

Aging Cell, Volume 25, Issue 2, February 2026.
Human trophoblast stem cell‐derived secretome/conditioned medium (hTSC‐CM) and the extracellular vesicles (EVs) therein suppress DNA damage and NF‐κB activation in senescent fibroblasts, in turn reducing the production of senescence‐associated secretory phenotype (SASP) factors. This study highlights hTSC‐CM and EVs as potential senotherapeutic agents.
Kotb Abdelmohsen, Jennifer L. Martindale, Martina Rossi, Chang Hoon Shin, Apala Pal, Rachel Munk, Martin Salamini‐Montemurri, Mirko Baranzini, Ethan M. Arends, Maja Mustapic, Yuta Lee, Jau‐Nan Lee, Sicco H. Popma, Justin Hu, Nathan Duda, Carlos J. Nogueras‐Ortiz, Dimitrios Kapogiannis, Chang‐Yi Cui, Myriam Gorospe   +18 more
wiley   +1 more source

Telomere Length and COVID-19 Severity: A Comparative Cross-Sectional Study Across the Clinical Spectrum. [PDF]

Healthcare (Basel)
Bacopoulou F, Tentolouris A, Koniari E, Kalogirou D, Basoulis D, Eleftheriadou I, Grigoropoulou P, Efthymiou V, Georgoulia KK, Anastasiou IA, Papadodima S, Chrousos G, Tentolouris N.   +12 more
europepmc   +1 more source

Telomere length and metabolic dysfunction-associated steatotic liver disease risk and progression: A systematic review and meta-analysis

Chunfeng Sun, Ping Qiu, Shuo Huang, Qihan Luo, Qing Ma, Piao Hu, Ping Qiu, Hongyan Wu, Chunxiao Chen   +8 more
openalex   +1 more source

Hevin Promotes Aging‐Related Cardiac Dysfunction via Facilitating Cardiac Inflammation in Male Mice

Aging Cell, Volume 25, Issue 2, February 2026.
Hevin released by iWAT into circulation stimulates cardiac macrophages through TLR4, inducing their polarization and CCL5 secretion, leading to worsened cardiac dysfunction and subsequent recruitment of additional inflammatory cells for pro‐inflammatory factor release.
Shi‐Yu Huang, Yu‐Jie Chen, Yu‐Xin Hu, Jia‐Chen Liu, Min Hu   +4 more
wiley   +1 more source

Telomeres control human telomerase (<i>TERT</i>) expression through non-telomeric TRF2. [PDF]

Elife
Sengupta A, Vinayagamurthy S, Soni D, Deb R, Mukherjee AK, Dutta S, Jaiswal J, Yadav M, Sharma S, Bagri S, Roy SS, Poonia P, Singh A, Khanna D, Bhatt AKK, Sharma A, Saurav S, Motiani RK, Chowdhury S.   +18 more
europepmc   +1 more source

DsDNA breaks inflicted by cell-free chromatin particles selectively target telomeres. [PDF]

Sci Rep
Birwatkar S, Ghosh T, Selukar R, Lopes R, Khare NK, Raghuram GV, Shabrish S, Mittra I.   +7 more
europepmc   +1 more source

The leaves fall, yet the tree endures. [PDF]

Cell Mol Life Sci
Fojtová M, Schrumpfová PP, Fajkus J.
europepmc   +1 more source