Results 241 to 250 of about 66,266 (300)

Germline <i>POT1</i> variants are associated with long telomeres and an unexpected broad spectrum of malignancies. [PDF]

Genet Med Open
Abu Shtaya A, Aloni S, Eskin-Schwartz M, Asher N, Azulay N, Basel-Salmon L, Bazak L, Bernstein Molho R, Douiev L, Barhom SF, Friedman E, Isakov O, Mahamid A, Michaeli O, Kedar I, Levi Z, Liberman S, Mordechai S, Reiter O, Levi GR, Shkedi Rafid S, Sarsor Z, Uziel O, Simchoni S, Walsh T, Wolach O, Segol O, Yablonski-Peretz T, Zick A, Gluck A, Tzfati Y, Goldberg Y.   +31 more
europepmc   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Two dipeptide repeat proteins are produced from mammalian telomeric RNA previously thought to be a long non-coding RNA. [PDF]

RNA Biol
Al-Turki TM, Griffith JD.
europepmc   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

DVE-1 is a telomere-binding protein and links the NuRD complex to telomere regulation in <i>C. elegans</i>. [PDF]

iScience
Sluka J, Blake A, Podvalnaya N, Fradera-Sola A, Dietz S, Teschke L, Ceron-Noriega A, Herrera-Rodriguez R, Arz V, Ketting R, Padeken J, Nischwitz E, Butter F.   +12 more
europepmc   +1 more source

Intramuscular pathways of maladaptation in overtraining syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend The transition from adaptive overreaching to maladaptive overtraining and mechanisms through which excessive training load can lead to performance decline. Four interconnected pathophysiological domains are highlighted: neural fatigue, involving both central and peripheral components such as altered sensory feedback and reflex ...
Emily Shorter, Oscar Horwath, Sabrina Tzivia Barsky, Ferdinand von Walden, Johanna T. Lanner   +4 more
wiley   +1 more source

DNA damage response as a driver of PD-L1 expression in cellular senescence: implications for immune evasion and immunosenescence. [PDF]

Front Cell Dev Biol
Wang Y, Qin L.
europepmc   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

The nuclear pore complex as a spatial organizing hub for high-risk DNA lesions. [PDF]

Nucleus
DeAscanis D, Nam B, Song H, Kee Y.
europepmc   +1 more source

Chromosome movements in meiotic prophase: regulatory mechanisms and biological roles. [PDF]

Front Cell Dev Biol
Zhao L, Gao J.
europepmc   +1 more source