Results 241 to 250 of about 114,134 (356)

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

Replicative senescence induction in single cells is not predicted by telomere length, dysfunction, or oxidation. [PDF]

iScience
Passanisi V, Spencer SL.
europepmc   +1 more source

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase. [PDF]

Nat Commun
Harman A, Kartawinata M, Maroun NM, Nguyen DR, Rahman S, Hughes WE, Winardi K, Cohen SB, Cesare AJ, Lamm N, Bryan TM.   +10 more
europepmc   +1 more source

Supplementary material from "Birds with high lifetime reproductive success experience increased telomere loss"

, 2019
Joanna Sudyka, Aneta Arct, Szymon M. Drobniak, Lars Gustafsson, Mariusz Cichoń   +4 more
openalex   +1 more source

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source

Telomere Length Abnormality: Investigating Approaches and Correlations with Cancer, Bone Marrow Failure and Hematological Malignancies. [PDF]

Biomedicines
Tarella C, Ferrero D, Herrera Sanchez MB, Canestrale AR, Kholia S, Silengo L, Derenzini E, Ricca I.   +7 more
europepmc   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Rapid loss of viability in acute myeloid leukemia cells upon telomerase inactivation. [PDF]

Blood Adv
Aquilanti E, Kageler L, Bozinov V, Meyerson M.   +3 more
europepmc   +1 more source

Author response: Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking

, 2018
Jamshid Faraji, Mitra Karimi, Nabiollah Soltanpour, Alireza Moharrerie, Zahra Rouhzadeh, Hamid Lotfi, Seyed Abedin Hosseini, S Yaghoob Jafari, Shabnam Roudaki, Reza Moeeini, Gerlinde A. S. Metz   +10 more
openalex   +1 more source