Results 231 to 240 of about 47,118 (266)

The Ruminant Telomere-to-Telomere (RT2T) Consortium

Nature Genetics
Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies ...
Kalbfleisch, Theodore, Mckay, Stephanie, Murdoch, Brenda, Adelson, David, Almansa-Villa, Diego, Becker, Gabrielle, Beckett, Linda, Benítez-Galeano, María José, Biase, Fernando, Casey, Theresa, Chuong, Edward, Clark, Emily, Clarke, Shannon, Cockett, Noelle, Couldrey, Christine, Davis, Brian, Elsik, Christine, Faraut, Thomas, Gao, Yahui, Genet, Carine, Grady, Patrick, Green, Jonathan, Green, Richard, Guan, Dailu, Hagen, Darren, Hartley, Gabrielle, Heaton, Mike, Hoyt, Savannah, Huang, Wen, Jarvis, Erich, Kalleberg, Jenna, Khatib, Hasan, Koepfi, Klaus-Peter, Koltes, James, Koren, Sergey, Kuehn, Christa, Leeb, Tosso, Leonard, Alexander, Liu, George, Low, Wai Yee, Mcconnell, Hunter, Mcrae, Kathryn, Miga, Karen, Mousel, Michelle, Neibergs, Holly, Olagunju, Temitayo, Pennell, Matt, Petry, Bruna, Pewsner, Mirjam, Phillippy, Adam, Pickett, Brandon, Pineda, Paulene, Potapova, Tamara, Rachagani, Satyanarayana, Rhie, Arang, Rijnkels, Monique, Robic, Annie, Rodriguez Osorio, Nelida, Safonova, Yana, Schettini, Gustavo, Schnabel, Robert, Sirpu Natesh, Nagabhishek, Stegemiller, Morgan, Storer, Jessica, Stothard, Paul, Stull, Caleb, Tosser-Klopp, Gwenola, Traglia, Germán, Tuggle, Christopher, van Tassell, Curtis, Watson, Corey, Weikard, Rosemarie, Wimmers, Klaus, Xie, Shangqian, Yang, Liu, Smith, Timothy, O’neill, Rachel, Rosen, Benjamin   +77 more
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Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres

Journal of Pediatric Surgery, 2009
Neuroblastoma (NBL) shows remarkable biologic heterogeneity, resulting in favorable or unfavorable prognoses. Previously, we reported that most unfavorable NBLs express high telomerase activity to maintain telomere length. Recently, telomere binding proteins (TBPs) and alternative lengthening of telomeres (ALTs) have been identified as key factors of ...
Yoshiyuki, Onitake, Eiso, Hiyama, Naomi, Kamei, Hiroaki, Yamaoka, Taijiro, Sueda, Keiko, Hiyama   +5 more
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Telomeres and frailty

Mechanisms of Ageing and Development, 2008
Associations between telomere length and various chronic diseases associated with ageing have led to the suggestion that telomere length may be an ageing biomarker. At the clinical level, the suggestion of using measurements of frailty as a measure of biological ageing has also been suggested. This study examines the hypothesis that telomere shortening
J, Woo, N L S, Tang, E, Suen, J C S, Leung, P C, Leung   +4 more
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TELOMERES AND THEIR CONTROL

Annual Review of Genetics, 2000
▪ Abstract  Telomeres are DNA and protein structures that form complexes protecting the ends of chromosomes. Understanding of the mechanisms maintaining telomeres and insights into their function have advanced considerably in recent years. This review summarizes the currently known components of the telomere/telomerase functional complex, and focuses ...
M J, McEachern, A, Krauskopf, E H, Blackburn   +2 more
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Telomeres to go

Science Signaling, 2022
By acquiring telomeres from antigen-presenting cells, some T cells are protected from senescence.
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Telomeres and Their Synthesis

Science, 1990
Telomeres, the specialized DNA-protein structures found at the ends of every eukaryotic chromosome, are required to stabilize chromosomes. Telomeric DNA, comprising the extreme molecular ends of chromosomes, consists of simple tandemly repeated sequences, characterized by clusters of G residues is one strand.
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Telomeres in cancer

Differentiation, 2018
Telomere shortening as a consequence of cell divisions during aging and chronic diseases associates with an increased cancer risk. Experimental data revealed that telomere shortening results in telomere dysfunction, which in turn affects tumorigenesis in two ways.
Cagatay, Gunes, Alush Irene, Avila, K Lenhard, Rudolph   +2 more
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Human Telomeres and Telomere Biology Disorders

2014
Telomeres consist of long nucleotide repeats and a protein complex at chromosome ends essential for chromosome stability. Telomeres shorten with each cell division and thus are markers of cellular age. Dyskeratosis congenita (DC) is a cancer-prone inherited bone marrow failure syndrome caused by germ-line mutations in key telomere biology genes that ...
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Of telomeres and tumors

Nature Medicine, 1996
The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.
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Telomeres and Aging

Physiological Reviews, 2008
Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must “cap” each chromosome end to avoid activation of DNA repair pathways.
Geraldine, Aubert, Peter M, Lansdorp
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