Results 231 to 240 of about 66,266 (300)

STING deficiency does not rescue short telomere-mediated aging phenotypes and longevity in TERC- or TERT-telomerase deficient mice.

Cell Rep
Marión RM, González JC, Flores JM, Piñeiro-Yáñez E, Serrano R, Blasco MA.   +5 more
europepmc   +1 more source

Centromeric footprints preserve telomere integrity in ALT cancers. [PDF]

Nature
Bhargava R, Mahlke MA, Schmidt TT, Bartenhagen C, Smith BA, Ramsey KL, Zuehlke TT, Bowman RW, Lynskey ML, Wondisford AR, Ouriou JB, Schamus-Hayes S, Calderon MJ, Watkins SC, Williams-Wehner AE, Bone JM, Joglekar AV, Fischer M, Karlseder J, Nechemia-Arbely Y, O'Sullivan RJ.   +20 more
europepmc   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Quantifying telomere length: from bulk assays to single-molecule resolution. [PDF]

Biophys Rep
Ma K, Yu Z.
europepmc   +1 more source

Impact of Letermovir on Voriconazole Concentrations in Lung Transplant Patients

Transplant Infectious Disease, EarlyView.
Concomitant letermovir was associated with lower voriconazole exposure and reduced attainment of commonly used efficacy thresholds in lung transplant recipients. Routine therapeutic drug monitoring after letermovir initiation is recommended, and empiric voriconazole dose escalation may be needed to avoid subtherapeutic exposure. ABSTRACT Background The
Leah Georgiades, Sunish Shah, Erin K. McCreary, Fernanda Silveira, Raman Venkataramanan, Vignesh Vasudevan, Ryan M. Rivosecchi   +6 more
wiley   +1 more source

A direct protein bridge connects the ds and ds-ss junction telomeric DNA segments in <i>C. elegans</i>. [PDF]

Sci Adv
Tesmer VM, Lambacher NJ, Yamamoto I, Nandakumar J, Shibuya H.   +4 more
europepmc   +1 more source

Targeting telomeres in brain vasculature does not impede initiation and progression of glioblastoma. [PDF]

PLoS One
Sánchez-Hernández A, Burgaz S, Louzame-Ruano J, Laguía Ó, Bosso G, Serrano R, López AC, Flores JM, Martínez P, Blasco MA.   +9 more
europepmc   +1 more source

A role for nucleosome remodellers during resection of deprotected telomeres in yeast. [PDF]

PLoS One
Deiser AM, Agar C, Barba Tena JD, Pfander B.   +3 more
europepmc   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source