Results 251 to 260 of about 66,266 (300)

Selective killing of ALT-cancer cells by Withaferin-A involves destabilization of Rad51 and disruption of DNA repair. [PDF]

open access: yesCell Death Dis
Yu Y   +8 more
europepmc   +1 more source

Addendum: Telomouse-a mouse model with human-length telomeres generated by a single amino acid change in RTEL1. [PDF]

open access: yesNat Commun
Smoom R   +12 more
europepmc   +1 more source

New perspectives on the physiological basis of muscle loss

open access: yes
Experimental Physiology, EarlyView.
Alistair J. Monteyne, Marlou L. Dirks
wiley   +1 more source

Science of omics: a molecular space odyssey

open access: yes
Experimental Physiology, EarlyView.
Salomé Coppens   +3 more
wiley   +1 more source

Telomere-associated non-malignant pulmonary diseases: Pathogenic mechanisms and therapeutic strategies. [PDF]

open access: yesActa Pharm Sin B
Zhan H   +8 more
europepmc   +1 more source
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Telomeres in evolution and evolution of telomeres

Chromosome Research, 2005
This paper examines telomeres from an evolutionary perspective. In the monocot plant order Asparagales two evolutionary switch-points in telomere sequence are known. The first occurred when the Arabidopsis-type telomere was replaced by a telomere based on a repeat motif more typical of vertebrates. The replacement is associated with telomerase activity,
Jirí, Fajkus   +2 more
openaire   +2 more sources

Telomere telomere recombination provides an express pathway for telomere acquisition

Nature, 1990
DNA termini from Tetrahymena and Oxytricha, which bear C4A2 and C4A4 repeats respectively, can support telomere formation in Saccharomyces cerevisiae by serving as substrates for the addition of yeast telomeric C1-3A repeats. Previously, we showed that linear plasmids with 108 base pairs of C4A4 DNA (YLp108CA) efficiently acquired telomeres, whereas ...
S S, Wang, V A, Zakian
openaire   +2 more sources

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

Nature Reviews Cancer, 2011
Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are progressively lost with each round of cell division. Telomere protection requires a minimal length of TTAGGG repeats to allow the binding of shelterin, which prevents the activation of a DNA damage response (DDR) at chromosome ends.
Paula Mart�nez, Mar�a A. Blasco
openaire   +2 more sources

Telomeres

Experimental Gerontology, 2006
The role that telomere biology may play in the human ageing process is of a significant interest to many laboratories around the world. In this, the first of a series of yearly reviews on telomeres and ageing, I review a small selection of papers published between July 2005 and June 2006 that maybe of direct relevance to the gerontology research ...
openaire   +2 more sources

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