Results 261 to 270 of about 59,567 (314)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, Volume 20, Issue 6, Page 1388-1391, June 2026.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Replicative senescence induction in single cells is not predicted by telomere length, dysfunction, or oxidation. [PDF]

iScience
Passanisi V, Spencer SL.
europepmc   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, Volume 16, Issue 6, Page 1181-1196, June 2026.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing. [PDF]

BMC Med
Aas M, Hoppen TH, Morina N, Zhang S, Li B, Mlakar V, Mutz J.   +6 more
europepmc   +1 more source

Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase. [PDF]

Nat Commun
Harman A, Kartawinata M, Maroun NM, Nguyen DR, Rahman S, Hughes WE, Winardi K, Cohen SB, Cesare AJ, Lamm N, Bryan TM.   +10 more
europepmc   +1 more source

SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres. [PDF]

Neuro Oncol
Brown A, Strickland LM, Erman EN, Pirozzi CJ, Low JT, Diplas BH, Gibson E, Shobande M, Khambati T, Krylova M, Liu H, McLendon RE, Reitman ZJ, Keir ST, Zou L, Ashley DM, Waitkus MS.   +16 more
europepmc   +1 more source

Telomere Length Abnormality: Investigating Approaches and Correlations with Cancer, Bone Marrow Failure and Hematological Malignancies. [PDF]

Biomedicines
Tarella C, Ferrero D, Herrera Sanchez MB, Canestrale AR, Kholia S, Silengo L, Derenzini E, Ricca I.   +7 more
europepmc   +1 more source

Shorter kidney telomeres are associated with nephrosclerosis by an epigenetic signature. [PDF]

Cardiovasc Res
Akinnibosun OA, Xu X, Emmett A, Nguyen H, Hames-Fathi S, Drzal M, Eales J, Scannali D, Prestes PR, Denniff M, Bogdanski P, Zywiec J, Wystrychowski W, Zukowska-Szczechowska E, Guzik TJ, Samani NJ, Dormer J, Tomaszewski M, Charchar FJ.   +18 more
europepmc   +1 more source

Rapid loss of viability in acute myeloid leukemia cells upon telomerase inactivation. [PDF]

Blood Adv
Aquilanti E, Kageler L, Bozinov V, Meyerson M.   +3 more
europepmc   +1 more source