Results 281 to 290 of about 59,567 (314)
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Mechanisms of Ageing and Development, 2008
Associations between telomere length and various chronic diseases associated with ageing have led to the suggestion that telomere length may be an ageing biomarker. At the clinical level, the suggestion of using measurements of frailty as a measure of biological ageing has also been suggested. This study examines the hypothesis that telomere shortening
J, Woo +4 more
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Associations between telomere length and various chronic diseases associated with ageing have led to the suggestion that telomere length may be an ageing biomarker. At the clinical level, the suggestion of using measurements of frailty as a measure of biological ageing has also been suggested. This study examines the hypothesis that telomere shortening
J, Woo +4 more
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Annual Review of Genetics, 2000
▪ Abstract Telomeres are DNA and protein structures that form complexes protecting the ends of chromosomes. Understanding of the mechanisms maintaining telomeres and insights into their function have advanced considerably in recent years. This review summarizes the currently known components of the telomere/telomerase functional complex, and focuses ...
M J, McEachern +2 more
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▪ Abstract Telomeres are DNA and protein structures that form complexes protecting the ends of chromosomes. Understanding of the mechanisms maintaining telomeres and insights into their function have advanced considerably in recent years. This review summarizes the currently known components of the telomere/telomerase functional complex, and focuses ...
M J, McEachern +2 more
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Differentiation, 2018
Telomere shortening as a consequence of cell divisions during aging and chronic diseases associates with an increased cancer risk. Experimental data revealed that telomere shortening results in telomere dysfunction, which in turn affects tumorigenesis in two ways.
Cagatay, Gunes +2 more
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Telomere shortening as a consequence of cell divisions during aging and chronic diseases associates with an increased cancer risk. Experimental data revealed that telomere shortening results in telomere dysfunction, which in turn affects tumorigenesis in two ways.
Cagatay, Gunes +2 more
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Science, 1990
Telomeres, the specialized DNA-protein structures found at the ends of every eukaryotic chromosome, are required to stabilize chromosomes. Telomeric DNA, comprising the extreme molecular ends of chromosomes, consists of simple tandemly repeated sequences, characterized by clusters of G residues is one strand.
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Telomeres, the specialized DNA-protein structures found at the ends of every eukaryotic chromosome, are required to stabilize chromosomes. Telomeric DNA, comprising the extreme molecular ends of chromosomes, consists of simple tandemly repeated sequences, characterized by clusters of G residues is one strand.
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Human Telomeres and Telomere Biology Disorders
2014Telomeres consist of long nucleotide repeats and a protein complex at chromosome ends essential for chromosome stability. Telomeres shorten with each cell division and thus are markers of cellular age. Dyskeratosis congenita (DC) is a cancer-prone inherited bone marrow failure syndrome caused by germ-line mutations in key telomere biology genes that ...
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Nature Medicine, 1996
The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.
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The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.
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Physiological Reviews, 2008
Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must “cap” each chromosome end to avoid activation of DNA repair pathways.
Geraldine, Aubert, Peter M, Lansdorp
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Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must “cap” each chromosome end to avoid activation of DNA repair pathways.
Geraldine, Aubert, Peter M, Lansdorp
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Scientific American, 1991
An ultimate goal of human genetics is the generation of a complete physical and ''functional'' map of the human genome. Twenty-five percent of human DNA, however, consists of repetitive DNA sequences. These repetitive DNA sequences are thought to arise by many mechanisms, from direct sequence amplification by the unequal recombination of homologous DNA
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An ultimate goal of human genetics is the generation of a complete physical and ''functional'' map of the human genome. Twenty-five percent of human DNA, however, consists of repetitive DNA sequences. These repetitive DNA sequences are thought to arise by many mechanisms, from direct sequence amplification by the unequal recombination of homologous DNA
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Experimental Gerontology, 2007
The extent and potential significance of telomere erosion, as a function of age in human tissues, is becoming increasingly apparent. In this, the second yearly review on telomeres and ageing, I review a small selection of papers published between July 2006 and June 2007.
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The extent and potential significance of telomere erosion, as a function of age in human tissues, is becoming increasingly apparent. In this, the second yearly review on telomeres and ageing, I review a small selection of papers published between July 2006 and June 2007.
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Current Opinion in Genetics & Development, 1993
The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
openaire +2 more sources