Results 171 to 180 of about 93,221 (259)

Sex differences in genomics, immune microenvironment and immunotherapy response in adult grade 4 gliomas

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Overall survival of patients with brain tumors receiving ICIs treatment Abstract Purpose Sex differences in the prevalence of gliomas have been reported; however, whether there are sex differences in the development and immunotherapy of gliomas remains poorly understood.
Feng Tang, Zhen‐Yuan Liu, Xi Chen, Jin‐Zhou Yang, Zhi‐Qiang Li   +4 more
wiley   +1 more source

The Application of Metal–Organic Frameworks as Drug Delivery Systems: From the Perspective of Molecular Dynamics Simulations

MedComm, Volume 7, Issue 4, April 2026.
This review article provides a comprehensive exploration of the synergistic integration of molecular dynamics (MD) simulations and metal–organic frameworks (MOFs) to advance the design and optimization of nanoscale drug delivery systems (DDSs). We believe this work will be of significant interest to researchers in nanomedicine, computational biology ...
Jiahao Xu, Hanzi Zheng, Yue Gao, Yuanqiu Lai, Mengya Peng, Yike Hu, Tianmeng Yuan, Xiang Liu, Shihan Zhou, Wei Duan, Jia‐Wei Shen, Yongke Zheng   +11 more
wiley   +1 more source

The Nexus of Stemness, Telomere Stability, and Metabolic Reprogramming in Glioblastoma: Foundations of Tumor Persistence and Targets for Intervention

MedComm, Volume 7, Issue 4, April 2026.
Integrated schematic depicting the interplay between glioma stem‐like cells, telomere maintenance mechanisms, and metabolic reprogramming in shaping immune suppression and therapeutic resistance in glioblastoma . ABSTRACT Glioblastoma (GBM) is a highly aggressive, therapy‐resistant brain tumor with inevitable recurrence despite maximal multimodal ...
Ji‐Yong Sung, Kihwan Hwang
wiley   +1 more source

Non‐Viral Cytokine‐Inducible SH2 Containing Protein Locus‐Specific Integrated Fibroblast Activation Protein Alpha‐Targeting Chimeric Antigen Receptor T Cells Achieve Potent Antitumor Efficacy in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
FAPα is a dual target on glioblastoma cells and perivascular cells. Using a high‐affinity anti‐FAPα nanobody, we generated CISH‐KO FAPα‐CAR‐T cells via non‐viral CRISPR–Cas9 integration. These cells demonstrated enhanced proliferation and superior antitumor efficacy in patient‐derived organoids and orthotopic mouse models compared to conventional CAR‐T
Xin Dong, Yao Sun, Yuetong Guo, Jiao Wang, Fei Wang, Ziming Wang, Ruizhen Li, Fei Xie, Tingting Tan, Baijie Cheng, Ronghan Huang, Shu Zhang, Xiaotong Lin, Zhaoze Guo, Hubing Wu, Hao Wu, Xubiao Zhang, Guozhu Xie   +17 more
wiley   +1 more source

Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy

MedComm, Volume 7, Issue 4, April 2026.
In this review, we summarize nerve–cancer interactions and conclude two additional interactions, “perineural invasion” and “neuro‐microbic‐oncology.” Emphasizing the important role of nerves in tumor progression. The nervous system also contributes to the development of cancer comorbidities such as cancer depression and cognitive dysfunction.
Ting Wang, Zikai Dong, Yongfei Wang, Ziyi An, Siyuan Wang, Wei‐Lin Jin   +5 more
wiley   +1 more source

Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma

MedComm, Volume 7, Issue 4, April 2026.
ZYH005 exerts potent anti‐glioblastoma activity through a dual mechanism: intercalation‐mediated DNA damage and targeted inhibition of EGFR, leading to cell cycle arrest and mitotic catastrophe. ABSTRACT Glioblastoma multiforme (GBM) is an aggressive, therapy‐resistant brain tumor with limited treatment options.
Jianzheng Huang, Zijun Zhang, Yang Xiao, Ziming Zhao, Zengwei Luo, Junjun Liu, Suitian Lai, Chao Song, Shouchang Feng, Suojun Zhang, Xingjiang Yu, Qingyi Tong, Yonghui Zhang   +12 more
wiley   +1 more source

Oncolytic Therapy: Delivery System and New Therapeutic Strategies for Cancer

MedComm, Volume 7, Issue 4, April 2026.
This review summarizes recent advances in nanoparticle‐ and cell‐mediated OVs delivery strategies that improve biodistribution and tumor targeting while limiting immune clearance. It also examines combination approaches that enhance therapeutic efficacy through tumor microenvironment modulation or immune activation, thereby overcoming immunosuppression
Sikan Jin, Yi Zhang, Ziling Zhou, Yaqi Zhang, Ting Yu, Rui Xu, Lin Xu, Jidong Zhang, Longze Zhang, Shan Yang, Xianyao Wang   +10 more
wiley   +1 more source

Post‐translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Posttranslational modifications (PTMs) serve as rapid and reversible molecular switches that reshape protein activity, stability, and interactomes, thereby governing virtually all physiological cues ranging from signal transduction to epigenetic memory. Mass spectrometry‐based proteomics has substantially expanded our understanding of PTM emergence and
Shuning Zhang, Jingmin Li, Meihuan Chen, Hailong Huang   +3 more
wiley   +1 more source

Tumor Organoid and Microenvironment Cocultures: Implications for Basic and Translational Cancer Research

MedComm, Volume 7, Issue 4, April 2026.
Organoid technology has attracted significant attention in cancer research. By incorporating tumor organoids with elements of the tumor microenvironment in coculture systems, researchers have gained powerful new tools to unravel the complex interplay that influences tumor progression and therapeutic outcomes.
Jiajun Yang, Chunliang Cheng, Wenqin Luo, Xingfeng He, Yaqi Li, Xiang Hu, Sanjun Cai, Hai Zou, Shaobo Mo, Junjie Peng   +9 more
wiley   +1 more source

Venous Thromboembolism and Bleeding with Temozolomide-, Bevacizumab-, and Nitrosourea-Based Therapy in Glioma: A Dual-Database Pharmacovigilance Study. [PDF]

Cancers (Basel)
Hou X, Zhang Y, Liang C, Yao S.
europepmc   +1 more source