Results 91 to 100 of about 2,359,207 (304)

Temperature sensitivity of Eppley broadband radiometers [PDF]

Broadband radiometers manufactured by Eppley Laboratories Inc. are commonly used to measure irradiance from both ground-based and aircraft platforms. Namely, the pyranometer (Model PSP) measures irradiance in the .3 to 3.0 micron spectral region while ...
Cox, Stephen K., Smith, William L., Jr.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Study on the changes in the temperature sensitivity of spring phenology of typical woody plants in the Qinling Mountains region

Frontiers in Earth Science
To reveal the responses of plant phenology and climate change in the Qinling Mountains region, the phenological data of seven woody plants in the Qinling Mountains region from 1964 to 2020 were selected to analyze the patterns and characteristics of ...
Shanhong Zhang, Qing Meng, Qian Ma, Hongying Bai, Shujuan Li   +4 more
doaj   +1 more source

On climate response to changes in the cosmic ray flux and radiative budget

, 2004
We examine the results linking cosmic ray flux (CRF) variations to global climate change. We then proceed to study various periods over which there are estimates for the radiative forcing, temperature change and CRF variations relative to today.
Ardanuy, Barron, Beer, Beer, Berner, Carslaw, Cess, Christl, Covey, Cubasch, Douglass, Eddy, Eichkorn, Ermakov, Farrar, Frank, Friis-Christensen, Frohlich, Gregory, Hansen, Hansen, Harrison, Hartmann, Herschel, Hobbs, Hodell, Hoffert, Hoyt, Intergovernmental Panel on Climate Change (IPCC), Jones, Kirkby, Labitzke, Lavielle, Lean, Lindzen, Lockwood, Lockwood, Marsden, Marsh, Marsh, Marsh, Masarik, McCracken, Myhre, Neff, Ney, Nir J. Shaviv, Palle Bago, Rind, Rosenfeld, Royer, Sharma, Shaviv, Shaviv, Shaviv, Shaviv, Shaviv, Solanki, Soon, Soon, Soon, Stephens, Svensmark, Svensmark, Twomey, Usoskin, Usoskin, Usoskin, Veizer, Waple, White, Yu   +71 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Novel experimental design for high pressure - high temperature electrical resistance measurements in a 'Paris-Edinburgh' large volume press

, 2015
We present a novel experimental design for high sensitivity measurements of the electrical resistance of samples at high pressures (0-6GPa) and high temperatures (300-1000K) in a 'Paris-Edinburgh' type large volume press.
Emuna, Moran, Greenberg, Yaron, Makov, Guy, Matityahu, Shlomi, Yahel, Eyal   +4 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Heatwaves Suppress Isoprene Emission Optima in Subtropical Eucalyptus: Implications for Biogenic VOC Modeling Under Extreme Thermal Events

Geophysical Research Letters
Isoprene emissions from tropical plants under moderate conditions are more temperature‐sensitive than temperate plants and current model predictions. However, the effect of extreme heatwaves on this sensitivity remains uncertain.
Jianqiang Zeng, Yanli Zhang, Weihua Pang, Haofan Ran, Hao Guo, Yuting Lu, Wei Song, Xinming Wang   +7 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source