Results 121 to 130 of about 2,359,207 (304)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Thermal Evaluation of the Initial Concept 3.X Vehicle at Mach 7
EnergiesHigh-speed global surface temperature distributions and heat flux measurements on the Initial Concept 3.X vehicle (IC3X) model were investigated at the UTSA Mach 7 wind tunnel, examining angles of attack of 0° and 5° at a freestream unit Reynolds number (
Abinayaa Dhanagopal +5 more
doaj +1 more source
An observational study of the carbon-sink strength of East Asian subtropical evergreen forests
Environmental Research Letters, 2012 Relatively little is known about the effects of regional warming on the carbon cycle of subtropical evergreen forest ecosystems, which are characterized by year-round growing season and cold winters.
Zheng-Hong Tan +15 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Causal hybrid modeling with double machine learning—applications in carbon flux modeling
Machine Learning: Science and TechnologyHybrid modeling integrates machine learning with scientific knowledge to enhance interpretability, generalization, and adherence to natural laws. Nevertheless, equifinality and regularization biases pose challenges in hybrid modeling to achieve these ...
Kai-Hendrik Cohrs +4 more
doaj +1 more source
Meikuang AnquanAn evaluation of low damage guar gum fracturing fluid system based on deep coalbed methane reservoir stimulation was carried out, its on-site application research was conducted.
Yongcheng ZHANG +5 more
doaj +1 more source
Environmental Research Letters, 2015 The current climate warming in the Arctic may increase the microbial degradation of vast pools of soil carbon (C); however, the temperature sensitivity of decomposition is often highly dependent on the quality of accumulated soil C. Grazing by reindeer (
Maria Väisänen +4 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Frontiers in GeochemistryGlobally peatlands store 25% of global soil organic carbon but this large carbon store is at risk under climate change and from widespread anthropogenic disturbances.
Elise M. Dehaen +6 more
doaj +1 more source