Results 81 to 90 of about 2,359,207 (304)

Engineering temperature-sensitive SH3 domains

open access: yesChemistry & Biology, 1999
The ability to control specific protein-protein interactions conditionally in vivo would be extremely helpful for analyzing protein-protein interaction networks. SH3 (Src homology 3) modular protein binding domains are found in many signaling proteins and they play a crucial role in signal transduction by binding to proline-rich sequences.Random in ...
Parrini, Maria Carla, Mayer, Bruce J
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Inscription and Thermal Stability of Fiber Bragg Gratings in Hydrogen-Loaded Optical Fibers Using a 266 nm Pulsed Laser

open access: yesPhotonics
Fiber Bragg gratings (FBGs) have gained substantial research interest due to their exceptional sensing capabilities. Traditionally, FBG fabrication has required the use of pre-hydrogenated fibers and high-cost laser systems such as excimer lasers at 193 ...
Xiangxi Zhu   +7 more
doaj   +1 more source

Cast composite solid propellants with different combustion stabilizers [PDF]

open access: yesScientific Technical Review, 2015
The effect of four different compounds as the combustion stabilizers of composite solid propellants based on the AP/HTPB/IPDI has been presented in this paper.
Rodić Vesna   +3 more
doaj  

Charge sensitivity of radio frequency single-electron transistor (RF-SET)

open access: yes, 1999
A theoretical analysis of the charge sensitivity of the RF-SET is presented. We use the ``orthodox'' approach and consider the case when the carrier frequency is much less than $I/e$ where $I$ is the typical current through RF-SET.
Korotkov, Alexander N.   +1 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Enhancing the Robustness and Efficiency in the Production of Medium Mn Steels by Al Addition

open access: yesMetals, 2020
The narrow process window during intercritical annealing and discontinuous yielding have limited the commercialization of medium Mn steels. In this study, a double-annealing process based on the commercial continuous annealing line is proposed.
Maokun Bai   +5 more
doaj   +1 more source

Effect of breed on thermal pain sensitivity in dogs : A thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Zoology at Massey University, Manawatū, New Zealand [PDF]

open access: yes, 2016
A problem in assessing pain sensitivity in animals is the variability among individuals within a species. Thermal nociceptive threshold (TNT) testing is used to measure pain sensitivity in animals. However, little research has been done on within species
Bowden, James
core  

Temperature control in transport delay systems [PDF]

open access: yes, 2010
A control architecture is proposed for temperature control in manufacturing applications based on the internal model principle. It is applied to a problem where the material exit temperature is to be controlled by changing the transportation speed to ...
Grimble, M.J., Hearns, G.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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