Results 81 to 90 of about 219,031 (288)
Evaluating openEHR for storing computable representations of electronic health record phenotyping algorithms [PDF]
, 2017 Electronic Health Records (EHR) are data generated during routine clinical care. EHR offer researchers unprecedented phenotypic breadth and depth and have the potential to accelerate the pace of precision medicine at scale.
Denaxas, Spiros +2 more
core +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Emerging trends in prime editing for precision genome editing
Experimental and Molecular MedicinePrime editing is an advanced genome editing technology that enables precise genetic modifications without inducing double-strand breaks or requiring donor DNA templates.
Jaesuk Lee, Jiyeon Kweon, Yongsub Kim
doaj +1 more source
An FCM–GABPN Ensemble Approach for Material Feeding Prediction of Printed Circuit Board Template
Applied Sciences, 2019 Accurate prediction of material feeding before production for a printed circuit board (PCB) template can reduce the comprehensive cost caused by surplus and supplemental feeding.
Shengping Lv +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Associative memory scheme for genetic algorithms in dynamic environments [PDF]
, 2006 Copyright @ Springer-Verlag Berlin Heidelberg 2006.In recent years dynamic optimization problems have attracted a growing interest from the community of genetic algorithms with several approaches developed to address these problems, of which the memory ...
A. Karaman +3 more
core +4 more sources
Eye tracking by genetic deformable template matching algorithm in video sequences [PDF]
Port-Said Engineering Research Journal, 2013 Eye detection and tracking has broad applications in human-computer interaction, behavioural analysis, computer graphics, security, and biology systems. In this paper, we propose innovative eye detection and tracking method in video sequences. The proposed method incorporates deformable template matching and genetic algorithm to overcome problems ...
Randa Atta, Rehab Farouk, Sheren Zakaria
openaire +2 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Bio-ProtocolGene-edited human pluripotent stem cells provide attractive model systems to functionally interrogate the role of specific genetic variants in relevant cell types.
Berta de La Cruz +6 more
doaj +1 more source