Results 61 to 70 of about 107,776 (362)

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Circulating P2X7 Receptor Signaling Components as Diagnostic Biomarkers for Temporal Lobe Epilepsy [PDF]

, 2021
Giorgia Conte, Aida Menéndez‐Méndez, Sebastian Bauer, Hany El‐Naggar, Mariana Alves, Annette Nicke, Norman Delanty, Felix Rosenow, David C. Henshall, Tobías Engel   +9 more
openalex   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

Advanced Science, EarlyView.
The axon initial segment (AIS), crucial for action potential initiation, serves as a prime locus for controlling network activity. Chandelier Cells (ChCs), evolved in the mammals, intricately target AISs, acting as gatekeepers for neuronal firing. Diminishing ChC input makes animals more prone to developing seizures, whereas fortifying this connection ...
Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai   +7 more
wiley   +1 more source

Neuroimaging in Pediatric Epilepsy

Brain Sciences, 2019
Pediatric epilepsy presents with various diagnostic challenges. Recent advances in neuroimaging play an important role in the diagnosis, management and in guiding the treatment of pediatric epilepsy.
Zakir Shaikh, Alcy Torres, Masanori Takeoka   +2 more
doaj   +1 more source

Hippocampal sclerosis – cause or consequence of mesial temporal lobe epilepsy in children? [PDF]

Romanian Journal of Neurology, 2012
Mesial temporal lobe epilepsy with hippocampal sclerosis is a well defined epileptic syndromic entity, especially in adults. In pediatric population, this syndrome has been less well studied, probable because of the particular electroclinical features of
Adriana Gabriela Albeanu, Sanda Magureanu, Dana Craiu, Lieven Lagae   +3 more
doaj   +1 more source

Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A [PDF]

, 2017
Epilepsy comprises several syndromes, amongst the most common being mesial temporal lobe epilepsy with hippocampal sclerosis. Seizures in mesial temporal lobe epilepsy with hippocampal sclerosis are typically drug-resistant, and mesial temporal lobe ...
Alhusaini, Saud, Becker, Albert, Becker, Felicitas, Berkovic, Samuel F., Blumcke, Ingmar, Buchfelder, Michael, Buono, Russell J., Catarino, Claudia B., Cavalleri, Gianpiero L., Chaves, João, Coras, Roland, Costa, Paulo P., da Silva, António M., Dahl, Hans-Henrik M., de Graan, Pierre N. E., Delanty, Norman, Depondt, Chantal, Doherty, Colin P., Dorn, Thomas, Duncan, Susan, Eriksson, Kai J., Gruber-Sedlmayr, Ursula, Hakonarson, Hakon, Hallmann, Kerstin, Hamer, Hajo M., Hansen, Jörg, Hessel, Ellen V. S., Hildebrand, Michael S., Kantanen, Anne-Mari, Kasperavičiūtė, Dalia, Kobow, Katja, Koeleman, Bobby P. C., Krämer, Günter, Kunz, Wolfram S., Kälviäinen, Reetta K., Leal, Bárbara, Lerche, Holger, Leu, Costin, Matarin, Mar, Meng Tan, K., Novy, Jan, O'Brien, Terence J., Pandolfo, Massimo, Paravidino, Roberta, Petrovski, Slave, Ramasamy, Adaikalavan, Reif, Philipp S., Reinthaler, Eva M., Robbiano, Angela, Rosenow, Felix, Ryten, Mina, Rössler, Karl, Scheffer, Ingrid E., Schlachter, Kurt, Schoch, Susanne, Silva, Berta M., Sisodiya, Sanjay M., Smith, Colin, Sperling, Michael R., Steinhoff, Bernhard J., Stogmann, Elisabeth, Striano, Pasquale, Théâtre, Emilie, Tostevin, Anna, Trabzuni, Daniah, von Lehe, Marec, Weale, Michael E., Weber, Yvonne, Zara, Federico, Zimprich, Fritz, Zumsteg, Dominik   +70 more
core  

Structural imaging biomarkers of sudden unexpected death in epilepsy. [PDF]

, 2015
Sudden unexpected death in epilepsy is a major cause of premature death in people with epilepsy. We aimed to assess whether structural changes potentially attributable to sudden death pathogenesis were present on magnetic resonance imaging in people who ...
Balestrini, Simona, Diehl, Beate, Duncan, John S, Harper, Ronald M, Koepp, Matthias, Lhatoo, Samden, Micallef, Caroline, Sander, Josemir W, Scott, Catherine, Sisodiya, Sanjay M, Thom, Maria, Vos, Sjoerd B, Wandschneider, Britta   +12 more
core   +3 more sources

Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE) [PDF]

, 2022
Burcu Azak Pazarlar, Sanjay S. Aripaka, Viktor Petukhov, Lars H. Pinborg, Konstantin Khodosevich, Jens D. Mikkelsen   +5 more
openalex   +1 more source

Update on Temporal Lobe Epilepsy [PDF]

Epilepsy Research and Treatment, 2013
Although the most common and best studied of focal epilepsies, a substantial proportion of patients with temporal lobe epilepsy (TLE) continue to have seizures despite medical therapy. Of these, surgery cannot be offered for most with bitemporal TLE while its effectiveness is limited in these and others because of memory and/or language concerns [1 ...
Mirsattari, Seyed M., Blume, Warren T.
openaire   +2 more sources

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source