Natural fish swim bladder-derived MPN-nanofibrous biomimetic system exhibit ECM-responsive signal regulation and promote robust tendon-bone healing. [PDF]
Shi L +7 more
europepmc +1 more source
Abstract Irreparable rotator cuff tears remain a challenging condition to manage surgically, particularly in young and active patients without significant glenohumeral osteoarthritis. Several solutions have been proposed, and more recently, superior capsular reconstruction using the long head of the biceps tendon has shown promising results using an ...
Julian Devigne +2 more
wiley +1 more source
Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing <i>via</i> histone lactylation-mediated cartilage regeneration. [PDF]
Zhang T, Huang Q, Gan KF.
europepmc +1 more source
Abstract Combined anterior cruciate ligament and anterolateral ligament reconstruction is indicated for patients with anterior cruciate ligament rupture and preoperative rotatory instability. In smaller patients, the smaller graft diameter and shorter lengths of the gracilis and semitendinosus graft may not be sufficient for performing a combined ...
Cheuk‐Wai Wong +4 more
wiley +1 more source
SHED-derived exosome-mimetics promotes rotator cuff tendon-bone healing via macrophage immunomodulation through NF-κB suppression and autophagy activation. [PDF]
He Y +11 more
europepmc +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Letter to the Editor: Leptin Enhances M1 Macrophage Polarization and Impairs Tendon-Bone Healing in Rotator Cuff Repair: A Rat Model. [PDF]
Cai X, Wang B, Cheng L, Ou Q.
europepmc +1 more source
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu +9 more
wiley +1 more source
Leptin Enhances M1 Macrophage Polarization and Impairs Tendon-Bone Healing in Rotator Cuff Repair: A Rat Model. [PDF]
Li Y +9 more
europepmc +1 more source
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang +13 more
wiley +1 more source

