Results 11 to 20 of about 5,941 (179)
Using Tenecteplase for Acute Ischemic Stroke: What Is the Hold Up? [PDF]
Western Journal of Emergency Medicine, 2020 Alteplase is the only Food and Drug Administration-approved intravenous (IV) thrombolytic medication for acute ischemic stroke. However, multiple recent studies comparing tenecteplase and alteplase suggest that tenecteplase is at least as efficacious as ...
Tony Zitek, Ramsey Ataya, Isabel Brea
doaj +3 more sources
Tenecteplase in large-vessel occlusion with or without thrombectomy: a meta-analysis [PDF]
Frontiers in NeurologyBackgroundDespite the growing adoption of Tenecteplase for stroke thrombolysis, key questions such as the role of bridging therapy and extended-window use in large-vessel occlusion (LVO) patients with or without access to endovascular thrombectomy (EVT ...
Ahmed Alkhiri +9 more
doaj +2 more sources
Enhancement of Tenecteplase Thrombolytic Actions Ex Vivo and In Vivo by Deoxyribonuclease I [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground We aimed to investigate the phenomenon of thrombolysis resistance in tenecteplase and its underlying causes and evaluate whether DNase‐1 (deoxyribonuclease I) targeting neutrophil extracellular traps (NETs) could enhance the thrombolytic ...
Shuhan Xu +9 more
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Comparison of tenecteplase vs. alteplase in addition to thrombectomy in patients with ischemic stroke caused by large vessel occlusion within 4.5 h: a network meta-analysis [PDF]
Frontiers in NeurologyBackgroundThe optimal reperfusion approach for acute ischemic stroke (AIS) due to large vessel occlusion (LVO) remains under debate. While endovascular thrombectomy (EVT) is the standard treatment, the role of intravenous thrombolysis before EVT ...
Wenkui Li +8 more
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Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke
Journal of the American Heart AssociationAlthough intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase.
Yunyun Xiong, Marc Fisher, Manjun Hao
exaly +3 more sources
Comparative effectiveness and safety of tenecteplase versus alteplase for intravenous thrombolysis in acute ischemic stroke: a retrospective study [PDF]
Frontiers in NeurologyBackgroundTenecteplase has been proposed as a practical alternative to alteplase for intravenous thrombolysis in acute ischemic stroke. Although randomised trials have demonstrated noninferiority, data from real-world comparative cohorts remain limited ...
Weili Zhao +4 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background The optimal dose of tenecteplase in acute ischemic stroke remains to be defined. We present a pooled analysis of the 2 NOR‐TESTs (Norwegian Tenecteplase Stroke Trials) exploring the efficacy and safety of tenecteplase, 0.4 mg/kg.
Vojtech Novotny +6 more
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Frontiers in Neurology, 2023 BackgroundThe optimal dose of tenecteplase vs. alteplase for acute ischemic stroke (AIS) has yet to be established. Therefore, we included the latest randomized controlled trials (RCT) to assess the efficacy and safety of different doses of tenecteplase ...
Huo Liang +8 more
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Medicina, 2022 Background and Objectives: The study aimed to investigate the efficacy of intravenous thrombolysis with Tenecteplase before thrombectomy for acute ischemic stroke (AIS) patients compared with previous results using Alteplase.
Agnete Teivane +6 more
doaj +1 more source
Stroke: Vascular and Interventional Neurology, 2023 Introduction Tenecteplase is increasingly being used as a first‐line treatment for acute ischemic stroke after several randomized studies demonstrated its safety and efficacy, resulting in a massive increase in the number of published studies on this ...
Brendan Huang
doaj +1 more source