Results 41 to 50 of about 4,707 (174)

Intravenous Thrombolysis Combined With Endovascular Treatment Versus Endovascular Treatment Alone in Acute Ischemic Stroke due to Tandem Lesions: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 16, Issue 8, August 2026.
Our systematic review and meta‐analysis evaluate whether intravenous thrombolysis (IVT) plus endovascular therapy (EVT) outperforms EVT alone in patients with acute ischemic stroke due to tandem lesions. Pooled data from nine studies involving 1756 patients demonstrate that IVT + EVT is associated with significantly higher rates of functional ...
Wenqian Wei, Chongxu Zhong, Jian Tang, Liufei Chen, Kunlong Yao, Liyong Li, Shengliang Shi, Yueling Zhang, Jian Zhang   +8 more
wiley   +1 more source

Effect of Prehospital Time on Door‐to‐Computed Tomography Time in Acute Ischemic Stroke: A Multicenter Study

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Objectives Timely brain imaging is critical for optimizing stroke treatment outcomes. Delays at the prehospital stage significantly impact acute ischemic stroke management. Computed tomography (CT) plays a vital role in guiding treatment decisions.
Kuo‐En Chen, Po‐Chun Wang, Sheng‐Feng Lin, Hui‐An Lin   +3 more
wiley   +1 more source

Tenecteplase infusion: The saviour in partially successful thrombolysis of prosthetic heart valve thrombosis

IHJ Cardiovascular Case Reports, 2021
A 20-year-old female, with history of mitral valve replacement presented with recent onset breathlessness. Cine fluoroscopy showed restricted leaflet mobility.
Dr A. Shaheer Ahmed, Dr Shivank Gupta, Dr Anwar Hussain Ansari   +2 more
doaj   +1 more source

Tenecteplase vs Alteplase Before Endovascular Therapy in Basilar Artery Occlusion

, 2021
Objective: to investigate the efficacy of tenecteplase (TNK), a genetically modified variant of alteplase with greater fibrin specificity and longer half-life than alteplase, prior to endovascular thrombectomy (EVT) in patients with basilar artery ...
Cameron Williams, Parsons, Mark William, Felix C. Ng, Daniel Kaiser, Rocco, Alessandro, Peter J. Mitchell, Wu, Teddy Y, Yan, Bernard, Alessandro Rocco, Fabrizio Sallustio, Peter Bailey, Mitchell, Peter J, Yassi, Nawaf, Francesco Arba, Fana Alemseged, Gregoire Boulouis, Nawaf Yassi, Teddy Y. Wu, Williams, Cameron, Kleinig, Timothy John, Sallustio, Fabrizio, Stephen M. Davis, Leonid Churilov, Billy O'Brien, O'Brien, Billy, Gagan Sharma, Darshan Shah, Bernard Yan, Kaiser, Daniel, Arba, Francesco, Campbell, Bruce C V, Diomedi, Marina, Churilov, Leonid, Ng, Felix C, Boulouis, Gregoire, Volker Puetz, Steven Bush, Francesca Di Giuliano, Marina Diomedi, Bruce C.V. Campbell, Bailey, Peter, Shah, Darshan, Timothy John Kleinig, Puetz, Volker, Morotti, Andrea, Sharma, Gagan, Bush, Steven, Davis, Stephen M, Dewey, Helen M, Dowling, Richard, Andrea Morotti, Helen M. Dewey, Alemseged, Fana, Richard Dowling, Mark William Parsons, Di Giuliano, Francesca   +55 more
core   +1 more source

Thrombolysis in Patients With Mild Ischemic Stroke: A Comparative Effectiveness Study From the Norwegian Stroke Registry

European Journal of Neurology, Volume 33, Issue 8, August 2026.
In this longitudinal study from the Norwegian Stroke Registry (2016–2022), the effectiveness of intravenous thrombolysis (IVT) was compared in 1736 IVT‐treated patients and 1736 not IVT‐treated patients with mild acute ischemic stroke by propensity score matching.
Elise K. Kristensen, Agnethe Eltoft, Torunn Varmdal, Bent Indredavik, Ellisiv B. Mathiesen   +4 more
wiley   +1 more source

Efficacy and safety of tenecteplase for acute ischemic stroke within an extended treatment window: a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials [PDF]

Journal of Neurocritical Care
Background In acute ischemic stroke (AIS), the treatment window for thrombolytics is 4.5 hours from symptom onset. Tenecteplase, a modified tissue plasminogen activator, may be effective over an extended treatment window (4.5–24 hours).
Hesham Kelani, Mohamed R. Abdelraouf, Hazem Mohamed Salamah, Eli Berglas, Toka Elboraay, Abdelrahman Mahmoud, Mohamed Abugdida, Nadia Albaramony, Ahmed Abd Elazim, Diana Greene-Chandos, Mohammad El-Ghanem, Volodymyr Vulkanov, Artem Sunik, Amit Khaneja, David P. Lerner, Fawaz Al-Mufti   +15 more
doaj   +1 more source

Consensus Recommendations for Clinical Pharmacist Integration into the Acute Stroke Care Team: Endorsed by the American College of Clinical Pharmacy, Neurocritical Care Society, Society for Academic Emergency Medicine, and Society of Critical Care Medicine, and affirmed by the American Academy of Neurology

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 7, July 2026.
Graphical abstract of consensus recommendations for clinical pharmacist integration into the acute stroke care team. ABSTRACT Clinical pharmacists are increasingly recognized as vital contributors to acute stroke care, yet their role remains inconsistently defined and underutilized across health care systems.
Brian W. Gilbert, Caitlin S. Brown, Nicole M. Acquisto, Kellyn K. Engstrom, Kevin J. Mercer, Gavin T. Howington, David E. Zimmerman, Michael Gottlieb, Alicia E. Mattson, Megan A. Rech, Erin D. Wieruszewski, Andrew J. Webb, Brett Faine, Lance C. Ray, Kent A. Owusu, Barbara Voetsch, Dana Gerberi, Kristin Cole, Fernanda Bellolio   +18 more
wiley   +1 more source

The Indiana University Brain Health Program to deliver amyloid‐targeted therapy to Alzheimer's disease patients

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION The Indiana University Brain Health Program was developed to support safe implementation of amyloid‐targeting therapies (ATTs) for early Alzheimer's disease (AD). METHODS We established Neurology Brain Health Navigators (neuroBHNs) to extend our Brain Health Navigator model into specialty care.
Jared R. Brosch, Sophia Wang, Liana G. Apostolova, Atul Agarwal, Jason W. Allen, Laurie Gutmann, Meredith Tobar, Linda Gonzalez, Dontraelle Johnson, Lindsay Treadway, Julie Connolly, Angela Tang, Ethan Lettich, Sam Davies, Nancy Kuhn, Dustin B. Hammers, David Clark, Martin Farlow, Deanna R. Willis, Nicole Fowler, Donna M. Wilcock   +20 more
wiley   +1 more source

Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Stroke and Vascular Neurology
Background The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis in an extended time window remains unknown.
Yilong Wang, Qiang Dong, Yi Sui, Leonid Churilov, Gang Li, Xiaoyu Zhou, Jin Zhang, Yu Geng, Hong-Qiu Gu, Danhong Wu, Longting Lin, Ying Guo, Xiaofei Yu, Mark Parsons, Yuwu Zhao, Yangmei Chen, Xin Cheng, Lumeng Yang, Jianhong Yang, Lan Hong, Yifeng Ling, Xueyuan Liu, Qijin Zhai, Liandong Zhao, Fan Gong   +24 more
doaj   +1 more source

Direct Thrombectomy vs. Combined Treatment With Intravenous Thrombolysis in the Extended Time Window: A Target Trial Emulation

European Journal of Neurology, Volume 33, Issue 7, July 2026.
This target‐trial emulation compared direct MT (n = 212) vs. IVT + MT (n = 135) in anterior‐circulation LVO patients treated 4.5–24 h or at wake‐up, eligible for IVT with perfusion mismatch. Using IPW with a non‐inferiority margin RD ≥ −1.3% for 90‐day mRS 0–2, direct MT was not non‐inferior to IVT + MT (adjRD −2.9%, 95% CI −6.64 to 0.84).
Ettore Nicolini, Antonio Ciacciarelli, Giovanni Pracucci, Valentina Saia, Luigi Simonetti, Andrea Zini, Valerio Da Ros, Federica D'agostino, Marta Iacobucci, Manuela De Michele, Marco Andrighetti, Rossana Tassi, Andra Saletti, Ilaria Casetta, Enrico Fainardi, Alfredo Pauciulo, Marcella Caggiula, Roberto Menozzi, Alessandro Pezzini, Stefano Vallone, Guido Bigliardi, Domenico Sergio Zimatore, Marco Petruzzellis, Alessio Comai, Enrica Franchini, Luca Allegretti, Tiziana Tassinari, Nicola Limbucci, Patrizia Nencini, Giuseppe Carità, Monia Russo, Marco Filizzolo, Marina Mannino, Maria Ruggiero, Marco Longoni, Andrea Boghi, Andrea Naldi, Mauro Bergui, Giovanni Bosco, Giuseppe Pelle, Michele Alessiani, Matteo Alberti, Paolo Invernizzi, Raffaele Augelli, Manuel Cappellari, Guido Andrea Lazzarotti, Nicola Giannini, Daniel Konda, Fabrizio Sallustio, Salvatore Mangiafico, Danilo Toni, on behalf of the IRETAS group   +51 more
wiley   +1 more source