Results 21 to 30 of about 3,406 (148)

Tenecteplase compared to alteplase in real-world outcome: A Swedish Stroke Register study

Upsala Journal of Medical Sciences
Background: Tenecteplase is increasingly used off-label as an alternative to alteplase for ischemic stroke thrombolysis. Our aim was to evaluate the safety of tenecteplase versus alteplase in comprehensive real-world data.
Mikael Skärlund, Signild Åsberg, Marie Eriksson, Erik Lundström   +3 more
doaj   +1 more source

Effect of Prehospital Time on Door‐to‐Computed Tomography Time in Acute Ischemic Stroke: A Multicenter Study

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Objectives Timely brain imaging is critical for optimizing stroke treatment outcomes. Delays at the prehospital stage significantly impact acute ischemic stroke management. Computed tomography (CT) plays a vital role in guiding treatment decisions.
Kuo‐En Chen, Po‐Chun Wang, Sheng‐Feng Lin, Hui‐An Lin   +3 more
wiley   +1 more source

Creation of Tenecteplase-Producing CHO Cell Line Using Site-Specific Integrase from the Phage φC31 [PDF]

Cell Journal, 2010
Objective: The aim of this study was to produce a stable CHO cell line expressing tenecteplase.Materials and Methods: In the first step, the tenecteplase coding sequence was clonedin a pDB2 vector containing attB recognition sites for the phage φC31 ...
Khadijeh Karbalaie, Mohammad Reza Mofid, Mohammad Hossain Nasr Esfahani, Michele P. Calos, Kianoush Dormiani, Pharm, Fereshteh Karamali, Kamran Ghaedi, Mahboobeh Forouzanfar, Yahya Khazaie, Pharm   +8 more
doaj  

Consensus Recommendations for Clinical Pharmacist Integration into the Acute Stroke Care Team: Endorsed by the American College of Clinical Pharmacy, Neurocritical Care Society, Society for Academic Emergency Medicine, and Society of Critical Care Medicine, and affirmed by the American Academy of Neurology

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 7, July 2026.
Graphical abstract of consensus recommendations for clinical pharmacist integration into the acute stroke care team. ABSTRACT Clinical pharmacists are increasingly recognized as vital contributors to acute stroke care, yet their role remains inconsistently defined and underutilized across health care systems.
Brian W. Gilbert, Caitlin S. Brown, Nicole M. Acquisto, Kellyn K. Engstrom, Kevin J. Mercer, Gavin T. Howington, David E. Zimmerman, Michael Gottlieb, Alicia E. Mattson, Megan A. Rech, Erin D. Wieruszewski, Andrew J. Webb, Brett Faine, Lance C. Ray, Kent A. Owusu, Barbara Voetsch, Dana Gerberi, Kristin Cole, Fernanda Bellolio   +18 more
wiley   +1 more source

Tenecteplase infusion: The saviour in partially successful thrombolysis of prosthetic heart valve thrombosis

IHJ Cardiovascular Case Reports, 2021
A 20-year-old female, with history of mitral valve replacement presented with recent onset breathlessness. Cine fluoroscopy showed restricted leaflet mobility.
Dr A. Shaheer Ahmed, Dr Shivank Gupta, Dr Anwar Hussain Ansari   +2 more
doaj   +1 more source

The Indiana University Brain Health Program to deliver amyloid‐targeted therapy to Alzheimer's disease patients

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION The Indiana University Brain Health Program was developed to support safe implementation of amyloid‐targeting therapies (ATTs) for early Alzheimer's disease (AD). METHODS We established Neurology Brain Health Navigators (neuroBHNs) to extend our Brain Health Navigator model into specialty care.
Jared R. Brosch, Sophia Wang, Liana G. Apostolova, Atul Agarwal, Jason W. Allen, Laurie Gutmann, Meredith Tobar, Linda Gonzalez, Dontraelle Johnson, Lindsay Treadway, Julie Connolly, Angela Tang, Ethan Lettich, Sam Davies, Nancy Kuhn, Dustin B. Hammers, David Clark, Martin Farlow, Deanna R. Willis, Nicole Fowler, Donna M. Wilcock   +20 more
wiley   +1 more source

Direct Thrombectomy vs. Combined Treatment With Intravenous Thrombolysis in the Extended Time Window: A Target Trial Emulation

European Journal of Neurology, Volume 33, Issue 7, July 2026.
This target‐trial emulation compared direct MT (n = 212) vs. IVT + MT (n = 135) in anterior‐circulation LVO patients treated 4.5–24 h or at wake‐up, eligible for IVT with perfusion mismatch. Using IPW with a non‐inferiority margin RD ≥ −1.3% for 90‐day mRS 0–2, direct MT was not non‐inferior to IVT + MT (adjRD −2.9%, 95% CI −6.64 to 0.84).
Ettore Nicolini, Antonio Ciacciarelli, Giovanni Pracucci, Valentina Saia, Luigi Simonetti, Andrea Zini, Valerio Da Ros, Federica D'agostino, Marta Iacobucci, Manuela De Michele, Marco Andrighetti, Rossana Tassi, Andra Saletti, Ilaria Casetta, Enrico Fainardi, Alfredo Pauciulo, Marcella Caggiula, Roberto Menozzi, Alessandro Pezzini, Stefano Vallone, Guido Bigliardi, Domenico Sergio Zimatore, Marco Petruzzellis, Alessio Comai, Enrica Franchini, Luca Allegretti, Tiziana Tassinari, Nicola Limbucci, Patrizia Nencini, Giuseppe Carità, Monia Russo, Marco Filizzolo, Marina Mannino, Maria Ruggiero, Marco Longoni, Andrea Boghi, Andrea Naldi, Mauro Bergui, Giovanni Bosco, Giuseppe Pelle, Michele Alessiani, Matteo Alberti, Paolo Invernizzi, Raffaele Augelli, Manuel Cappellari, Guido Andrea Lazzarotti, Nicola Giannini, Daniel Konda, Fabrizio Sallustio, Salvatore Mangiafico, Danilo Toni, on behalf of the IRETAS group   +51 more
wiley   +1 more source

Tenecteplase Versus Alteplase in Medium Vessel Occlusion Ischemic Stroke: A Secondary Analysis of the Alteplase Compared to Tenecteplase Randomized Trial [PDF]

Journal of Stroke
Background and Purpose The safety and efficacy of tenecteplase in patients with ischemic stroke due to medium vessel occlusion (MeVO) are not well studied. We aimed to compare tenecteplase with alteplase in stroke due to MeVO.
Fouzi Bala, Nishita Singh, Katrina Ignacio, Ibrahim Alhabli, Ayoola Ademola, Anas Alrohimi, Houman Khosravani, Aleksander Tkach, Luciana Catanese, Dariush Dowlatshahi, Thalia Field, Gary Hunter, Faysal Benali, MacKenzie Horn, Andrew Demchuk, Michael Hill, Tolulope Sajobi, Brian Buck, Richard Swartz, Mohammed Almekhlafi, Bijoy K. Menon   +20 more
doaj   +1 more source

Efficacy and Safety of Tirofiban for the Management of Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (RCTs)

Brain and Behavior, Volume 16, Issue 6, June 2026.
Graphical representation of the comparative efficacy and safety of intravenous tirofiban for acute ischemic stroke in randomized controlled trials. ABSTRACT Background: Tirofiban is a GP IIb/IIIa inhibitor, an anti‐platelet drug that is used in ischemic stroke or acute coronary syndromes.
Dorothy Lim Bullecer, Cara Mohammed, Julie Anne De Lima Loiola, Mary Gabrielle Te Chy, Samratul Fuadah Ramli, Abimbola Sodiq Hussein, Wasid Bin Showkat, Thahsin Taikadan, Sarika Mutyala, Muhammad Ayyan, Muhammad Aemaz Ur Rehman, Adeel Ahmad, Asma'a Munasar Ali Alsubari   +12 more
wiley   +1 more source

Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Stroke and Vascular Neurology
Background The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis in an extended time window remains unknown.
Yilong Wang, Qiang Dong, Yi Sui, Leonid Churilov, Gang Li, Xiaoyu Zhou, Jin Zhang, Yu Geng, Hong-Qiu Gu, Danhong Wu, Longting Lin, Ying Guo, Xiaofei Yu, Mark Parsons, Yuwu Zhao, Yangmei Chen, Xin Cheng, Lumeng Yang, Jianhong Yang, Lan Hong, Yifeng Ling, Xueyuan Liu, Qijin Zhai, Liandong Zhao, Fan Gong   +24 more
doaj   +1 more source