Results 31 to 40 of about 6,025 (196)

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Real-world efficacy and safety of Tenecteplase versus Alteplase in acute ischemic stroke: a propensity score-matched analysis

Frontiers in Neurology
BackgroundReal-world evidence comparing Tenecteplase and Alteplase for acute ischemic stroke (AIS) remains limited. This study aimed to evaluate the comparative efficacy and safety of these thrombolytic agents in an unselected patient cohort.MethodsThis ...
Peng Zhang, Liangyun Sun, Liangxue Wang
doaj   +1 more source

Predictors of in-hospital mortality in patients with ST-segment elevation myocardial infarction undergoing pharmacoinvasive treatment [PDF]

, 2013
OBJECTIVES: To identify predictors of in-hospital mortality in patients with acute myocardial infarction undergoing pharmacoinvasive treatment. METHODS: This was an observational, prospective study that included 398 patients admitted to a tertiary center
Alves, Claudia Maria Rodrigues, Amaral, Amaury, Barbosa, Adriano Henrique Pereira, Caixeta, Adriano, Carvalho, Antonio Carlos, Falcão, Felipe José de Andrade, Goncalves Junior, Iran, Perez, Fatima Cristina A., Sousa, Jose Marconi Almeida, Souza, José Augusto Marcondes de, Stefanini, Edson, Wilke, Luiz Carlos   +11 more
core   +5 more sources

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

RVG‐Modified BMSCs‐Derived Small Extracellular Vesicles Loaded With miR‐21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Bioengineered brain targeting RVG‐modified BMSCs‐derived small extracellular vesicles loaded with miR‐21 alleviate excessive autophagic neuronal injury after cerebral ischaemia via PTEN/Akt/mTOR pathway. ABSTRACT Ischaemic stroke (IS) leads to tragic disability and high adult mortality, while there are limited therapeutic measures for it.
Yiyang Li, Jiacheng Hu, Jinfen Chen, Manfei Zhou, Mingchun Liao, Yayue Yang, Jiahao Zhou, Yan Han, Bin Wang, Yonghua Zhao   +9 more
wiley   +1 more source

Tenecteplase compared to alteplase in real-world outcome: A Swedish Stroke Register study

Upsala Journal of Medical Sciences
Background: Tenecteplase is increasingly used off-label as an alternative to alteplase for ischemic stroke thrombolysis. Our aim was to evaluate the safety of tenecteplase versus alteplase in comprehensive real-world data.
Mikael Skärlund, Signild Åsberg, Marie Eriksson, Erik Lundström   +3 more
doaj   +1 more source

Amyloid‐related imaging abnormalities (ARIA) in anti‐amyloid therapies for Alzheimer's disease: An update from the Alzheimer's Association ARIA workgroup

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract In 2011, a workgroup of the Alzheimer's Association Research Roundtable introduced recommendations for detecting and monitoring amyloid‐related imaging abnormalities (ARIA) in Alzheimer's disease (AD) clinical trials. Since then, anti‐amyloid immunotherapies have received regulatory approval for AD treatment and are beginning to enter clinical
Ellis S. van Etten, Simin Mahinrad, Joshua D. Grill, Stephen Salloway, Alireza Atri, Petrice M. Cogswell, Tammie L. S. Benzinger, Takeshi Iwatsubo, Costantino Iadecola, Cynthia A. Lemere, James A. R. Nicoll, Steven M. Greenberg, Maria C. Carrillo, Clifford R. Jack Jr, Reisa A. Sperling   +14 more
wiley   +1 more source

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 4, April 2026.
Within minutes after ischemia onset, deprivation of oxygen and glucose leads to rapid ATP depletion, resulting in failure of Na+/K+‐ATPase activity and membrane depolarization. This ionic imbalance promotes uncontrolled synaptic release of glutamate and excessive activation of postsynaptic NMDA and AMPA receptors.
Meibiao Zhang, Jianxun Hou, Jia Kuang, Lei Hao, Zhao Yang   +4 more
wiley   +1 more source

Creation of Tenecteplase-Producing CHO Cell Line Using Site-Specific Integrase from the Phage φC31 [PDF]

Cell Journal, 2010
Objective: The aim of this study was to produce a stable CHO cell line expressing tenecteplase.Materials and Methods: In the first step, the tenecteplase coding sequence was clonedin a pDB2 vector containing attB recognition sites for the phage φC31 ...
Khadijeh Karbalaie, Mohammad Reza Mofid, Mohammad Hossain Nasr Esfahani, Michele P. Calos, Kianoush Dormiani, Pharm, Fereshteh Karamali, Kamran Ghaedi, Mahboobeh Forouzanfar, Yahya Khazaie, Pharm   +8 more
doaj  

Right Atrial Thrombus in Transit: A Case of Spontaneous Embolisation Captured Across Echocardiography

Respirology Case Reports, Volume 14, Issue 4, April 2026.
In this report, we describe a large RA thrombus in transit captured sequentially across multiple imaging modalities. This case highlights how quickly these thrombi can evolve and emphasises the need for individualised decision‐making when standard interventions are limited by clinical context.
Abdullah Al Qaraghuli, Sajjad Ghanim Al‐Badri, Mustafa Kadhim, Tala A. Haddad, Ronald Cadillo Hernandez, Sai Nitya Tejaswi Anne, Sashank Bollu, Ibrahim Khalil   +7 more
wiley   +1 more source