Results 31 to 40 of about 4,707 (174)

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke

Annals of Neurology, EarlyView.
Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary, Jean‐Philippe Desilles, Fatima Zemali, Astride Perrot, Lucas Di Meglio, Sara Zalghout, Jéromine Fasille, Jérémy Neel, Stéphane Loyau, Julien Labreuche, Marie‐Charlotte Bourrienne, Dorothée Faille, François Delvoye, Véronique Ollivier, Sébastien Dupont, Jasmina Rogozarski, Nahida Brikci‐Nigassa, Robert L. Medcalf, Nadine Ajzenberg, Mikael Mazighi, Benoît Ho‐Tin‐Noé, the compoCLOT Study Group   +21 more
wiley   +1 more source

Tenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial

Stroke and Vascular Neurology
Background The benefit–risk profile of tenecteplase in the elderly patients with acute ischaemic stroke (AIS) is uncertain. We sought to investigate the efficacy and safety of 0.25 mg/kg tenecteplase compared with alteplase for AIS patients aged ≥80 ...
Bruce C V Campbell, Yongjun Wang, Zixiao Li, Yunyun Xiong, Yuesong Pan, Lee H Schwamm, Shuya Li, Mengxing Wang, Na Wu, Liyuan Wang, Manjun Hao, Zhixin Cao, Chunmiao Duan, Shuangzhe Wu   +13 more
doaj   +1 more source

Pulmonary Embolism—A Century of Progress

ANZ Journal of Surgery, EarlyView.
Reviews a century of progress in the diagnosis, prevention, and management of pulmonary embolism; from the first successful surgical embolectomy in 1924 to advanced imaging, pharmacological thromboprophylaxis, and treatment. In the 21st century, advances include catheter‐directed thrombolysis or mechanical thrombectomy under decision‐making guidance of
D. A. Watters
wiley   +1 more source

Tenecteplase in Pulmonary Embolism Patients: A Meta-Analysis and Systematic Review

Frontiers in Medicine, 2022
ObjectiveTo assess the efficacy and safety of tenecteplase in patients with pulmonary embolism (PE).MethodsWe completed the literature search on May 31, 2021 using PubMed, EMBASE and the Web of Science.
Zhu Zhang, Zhu Zhang, Zhu Zhang, Zhu Zhang, Linfeng Xi, Linfeng Xi, Linfeng Xi, Linfeng Xi, Linfeng Xi, Shuai Zhang, Shuai Zhang, Shuai Zhang, Shuai Zhang, Yunxia Zhang, Yunxia Zhang, Yunxia Zhang, Yunxia Zhang, Guohui Fan, Guohui Fan, Guohui Fan, Guohui Fan, Xincao Tao, Xincao Tao, Xincao Tao, Xincao Tao, Qian Gao, Qian Gao, Qian Gao, Qian Gao, Wanmu Xie, Wanmu Xie, Wanmu Xie, Wanmu Xie, Peiran Yang, Zhenguo Zhai, Zhenguo Zhai, Zhenguo Zhai, Zhenguo Zhai, Chen Wang, Chen Wang, Chen Wang, Chen Wang, Chen Wang, Chen Wang   +43 more
doaj   +1 more source

NIHSS and Large Artery Atherosclerosis Affect Efficacy of Dual Antiplatelet Therapy Versus Alteplase for Minor Stroke

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Background Dual antiplatelet therapy (DAPT) was noninferior to alteplase in nondisabling minor stroke (NIHSS 0 to 5). Given potential benefit of DAPT in minor stroke with large artery atherosclerosis (LAA) and of alteplase in stroke with NIHSS 4–5, we hypothesize that neurological deficit and LAA may affect efficacy of DAPT versus alteplase in
Yu Cui, Zi‐Ang Li, Chao He, Hui‐Sheng Chen   +3 more
wiley   +1 more source

Creation of Tenecteplase-Producing CHO Cell Line Using Site-Specific Integrase from the Phage φC31 [PDF]

Cell Journal, 2010
Objective: The aim of this study was to produce a stable CHO cell line expressing tenecteplase.Materials and Methods: In the first step, the tenecteplase coding sequence was clonedin a pDB2 vector containing attB recognition sites for the phage φC31 ...
Khadijeh Karbalaie, Mohammad Reza Mofid, Mohammad Hossain Nasr Esfahani, Michele P. Calos, Kianoush Dormiani, Pharm, Fereshteh Karamali, Kamran Ghaedi, Mahboobeh Forouzanfar, Yahya Khazaie, Pharm   +8 more
doaj  

Cost analysis : switching from alteplase to tenecteplase for management of acute ischemic stroke [PDF]

, 2021
Background: Acute ischemic stroke (AIS) occurs due to obstructed blood flow into blood vessels to the brain and is considered a medical emergency. Thrombolytic therapy is the mainstay of AIS's acute management due to its benefit in improving ...
King, Claire Mary Rose
core   +2 more sources

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1893-1902, September 2026.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi, Daniel P. O. Kaiser, Martin Arndt, Norma J. Diel, Erik Simon, Witold H. Polanski, Volker Puetz, Hagen B. Huttner, Timo Siepmann   +8 more
wiley   +1 more source

Prospective Observational Cohort Study of Tenecteplase: Results From the Indian Registry in Ischemic Stroke-Tenecteplase

BACKGROUND: Tenecteplase has been approved for acute ischemic stroke at a dose of 0.2 mg/kg by the Indian licensing authority. A registry to evaluate the safety of tenecteplase was mandated by the licensing authority.
Ramakrishnan, TCR, Vijaya, P, Sharma, M, Saraf, A, Kumaravelu, S, Kalita, J, Sontakke, SM, Alurkar, A, Udar, M, Vaidya, B, Parsons, MW, Misra, UK, Pathan, S, Churilov, L, Singh, S, Komal Kumar, RN, Desai, S, Arjundas, D, Suresh, BV, Nair, RR, Machhavada, K, Pujari, SS, Gilvaz, PC, Kumar, S, Meenakshi-Sundaram, S   +24 more
core   +2 more sources