Results 31 to 40 of about 3,406 (148)

Pharmacokinetics and Neuroprotective Efficacy of Poly‐Arginine Peptide R18D in Sprague Dawley Rats Subjected to Transient Intraluminal Filament Middle Cerebral Artery Occlusion Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
The R18D peptide exhibits a favorable pharmacokinetic profile and significantly reduces infarct volume in a rat model of middle cerebral artery occlusion (MCAO) followed by reperfusion. These findings highlight the potential clinical utility of R18D as a neuroprotective therapy for stroke patients undergoing endovascular recanalization interventions ...
Bruno P. Meloni, Stuart K. Gribble, Meghan G. Thomas, Ayelet Weksler, Lena Finkelstein, Lena Fishtein, Dimitry Kovalchuk, Gilad Maximov, Avital Schauder, Keren Kigel‐Zur, Sigal Meilin   +10 more
wiley   +1 more source

Efficacy and safety of tenecteplase for acute ischemic stroke within an extended treatment window: a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials [PDF]

Journal of Neurocritical Care
Background In acute ischemic stroke (AIS), the treatment window for thrombolytics is 4.5 hours from symptom onset. Tenecteplase, a modified tissue plasminogen activator, may be effective over an extended treatment window (4.5–24 hours).
Hesham Kelani, Mohamed R. Abdelraouf, Hazem Mohamed Salamah, Eli Berglas, Toka Elboraay, Abdelrahman Mahmoud, Mohamed Abugdida, Nadia Albaramony, Ahmed Abd Elazim, Diana Greene-Chandos, Mohammad El-Ghanem, Volodymyr Vulkanov, Artem Sunik, Amit Khaneja, David P. Lerner, Fawaz Al-Mufti   +15 more
doaj   +1 more source

From Innovation to Validation: Strengthening Interventional Radiology Through Data

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Kaiwen Cabbabe, Gerard S. Goh, Charles Li, Matthew Lukies   +3 more
wiley   +1 more source

Bibliometric analysis of the usage of tenecteplase for stroke

International Journal of Emergency Medicine
Introduction In recent years, tenecteplase has been competing with alteplase as a treatment for acute ischemic stroke given its ease of administration, lower dosage, cost-effectiveness, and better safety data.
Garv Bhasin, Latha Ganti
doaj   +1 more source

Thrombolytic therapy for patients with acute ischemic stroke: systematic review and network meta-analysis of randomized trials

Frontiers in Neurology
ObjectiveTo systematically compare the benefits and risks of all thrombolytic agents (tenecteplase, reteplase, and alteplase) at different doses for thrombolytic therapy in patients with acute ischemic stroke (AIS).BackgroundAlteplase is the cornerstone ...
Li-Chao-Yue Sun, Wen-Shu Li, Wei Chen, Zhao Ren, Chun-Xing Li, Ze Jiang, Le Wang, De-Li Wang, Qing Xie   +8 more
doaj   +1 more source

Real-world comparative safety and efficacy of tenecteplase alteplase in acute ischemic stroke patients with large vessel occlusion

Therapeutic Advances in Neurological Disorders, 2021
Background and aims: Tenecteplase has recently emerged as an alternative thrombolytic agent in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO), possibly superior in achieving early reperfusion compared with alteplase.
Klearchos Psychogios, Lina Palaiodimou, Aristeidis H. Katsanos, Georgios Magoufis, Apostolos Safouris, Odysseas Kargiotis, Stavros Spiliopoulos, Ermioni Papageorgiou, Aikaterini Theodorou, Konstantinos Voumvourakis, Elias Broutzos, Elefterios Stamboulis, Georgios Tsivgoulis   +12 more
doaj   +1 more source

RVG‐Modified BMSCs‐Derived Small Extracellular Vesicles Loaded With miR‐21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Bioengineered brain targeting RVG‐modified BMSCs‐derived small extracellular vesicles loaded with miR‐21 alleviate excessive autophagic neuronal injury after cerebral ischaemia via PTEN/Akt/mTOR pathway. ABSTRACT Ischaemic stroke (IS) leads to tragic disability and high adult mortality, while there are limited therapeutic measures for it.
Yiyang Li, Jiacheng Hu, Jinfen Chen, Manfei Zhou, Mingchun Liao, Yayue Yang, Jiahao Zhou, Yan Han, Bin Wang, Yonghua Zhao   +9 more
wiley   +1 more source

Different doses of tenecteplase vs alteplase in thrombolysis therapy of acute ischemic stroke: evidence from randomized controlled trials

Drug Design, Development and Therapy, 2018
Na Xu,1,2,* Zhouqing Chen,1,* Chongshun Zhao,1 Tao Xue,1 Xin Wu,1 Xiaoou Sun,1 Zhong Wang1 1Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of ...
Xu N, Chen Z, Zhao C, Xue T, Wu X, Sun X, Wang Z   +6 more
doaj  

Amyloid‐related imaging abnormalities (ARIA) in anti‐amyloid therapies for Alzheimer's disease: An update from the Alzheimer's Association ARIA workgroup

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract In 2011, a workgroup of the Alzheimer's Association Research Roundtable introduced recommendations for detecting and monitoring amyloid‐related imaging abnormalities (ARIA) in Alzheimer's disease (AD) clinical trials. Since then, anti‐amyloid immunotherapies have received regulatory approval for AD treatment and are beginning to enter clinical
Ellis S. van Etten, Simin Mahinrad, Joshua D. Grill, Stephen Salloway, Alireza Atri, Petrice M. Cogswell, Tammie L. S. Benzinger, Takeshi Iwatsubo, Costantino Iadecola, Cynthia A. Lemere, James A. R. Nicoll, Steven M. Greenberg, Maria C. Carrillo, Clifford R. Jack Jr, Reisa A. Sperling   +14 more
wiley   +1 more source

Safety and efficacy comparison of Tenecteplase and Alteplase for clinically suspected large vessel occlusion strokes without thrombectomy

Cerebrovascular Diseases Extra
Introduction: Tenecteplase is a thrombolytic with higher fibrin affinity, and is potentially better in clot lysis. A higher spontaneous recanalization rate for large vessel occlusions strokes (LVO) had been shown in comparison studies with Alteplase ...
Wai Ting Lo, Wing Chi Fong, Chris Siu Kwan Chau, Moamina Ismail, Jessica Tsz Ching Li, Chong Ching Chan, Chi Him Simon Chan, Chung Yuen Chan, Germaine Hui-Fai Chan, Andrew Lung-Tat Chan, Man Sin Wong, Wai Yan Vivian Kwok, Hiu Fan Or, Shun Tim Chan, Ching Shing Fong, Nga Man Chan, Yuk Fai Cheung   +16 more
doaj   +1 more source