Simultaneous Intracranial and Spinal Hemorrhage Following Tenecteplase Thrombolysis for ST-Elevation Myocardial Infarction: A Case Report. [PDF]
Clin Case RepABSTRACT Central nervous system (CNS) hemorrhage is a serious complication of intravenous thrombolysis. Tenecteplase, a fibrin‐specific thrombolytic agent, has a lower risk of hemorrhage than other agents. We report the first documented case of simultaneous intracranial and spinal hemorrhage following intravenous administration of tenecteplase.
Palliyaguru T +4 more
europepmc +2 more sources
Tenecteplase Improves Door‐to‐Needle Time in Real‐World Acute Stroke Treatment
Stroke: Vascular and Interventional Neurology, 2021 Background We report the interim results of a process improvement initiative at a comprehensive stroke center in which all tPA (tissue‐type plasminogen activator)–eligible patients were given tenecteplase for acute ischemic stroke.
Jillian Hall +10 more
doaj +1 more source
Response by Bivard et al to letter regarding article, "Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials" [PDF]
, 2017 No abstract ...
Bivard, Andrew +2 more
core +1 more source
Neuroimaging as a selection tool and endpoint in preclinical and clinical trials [PDF]
, 2016 Standard imaging in acute stroke enables the exclusion of non-stroke structural CNS lesions and cerebral haemorrhage from clinical and pre-clinical ischaemic stroke trials. In this review, the potential benefit of imaging (e.g., angiography and penumbral
Macrae, I. Mhairi, Muir, Keith W.
core +2 more sources
No space Left for Intravenous thrombolysis in acute stroke [PDF]
, 2016 Recent successful clinical trials of endovascular thrombectomy for large artery ischaemic stroke have established the value of this treatment modality as an adjunct to intravenous thrombolysis, not as an alternative: thrombectomy delivery was undertaken ...
Muir, Keith
core +1 more source
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]
, 2017 Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat +6 more
core +3 more sources
Evaluation of an Unfractioned Heparin Pharmacy Dosing Protocol for the Treatment of Venous Thromboembolism in Nonobese, Obese, and Severely Obese Patients [PDF]
, 2017 Background: Despite large interpatient variability in dose response, heparin is utilized for treatment of venous thromboembolism (VTE). Current data on the optimal heparin dosing in obese patients are conflicting. Objective: The objective was to evaluate
Breedlove, Emily Y. +3 more
core +2 more sources
Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction [PDF]
, 2013 BACKGROUNDIt is not known whether prehospital fibrinolysis, coupled with timely coronary angiography, provides a clinical outcome similar to that with primary percutaneous coronary intervention (PCI) early after acute ST-segment elevation myocardial ...
Armstrong, Paul W. +22 more
core +1 more source
Tenecteplase vs. alteplase for acute ischemic stroke: a systematic review
International Journal of Emergency Medicine, 2022 Introduction Thrombolysis for acute ischemic stroke (AIS) with alteplase is the currently approved therapy for patients who present within 4.5 h of symptom onset and meet criteria.
Neha Potla, Latha Ganti
doaj +1 more source
Tenecteplase Versus Alteplase for First-Pass Reperfusion in Basilar Artery Occlusion Stroke Thrombectomy. [PDF]
Ann NeurolObjective The first‐pass effect (FPE), defined as excellent reperfusion after a single attempt, is associated with improved outcomes in large vessel occlusion stroke. We evaluated whether intravenous tenecteplase (TNK) compared with alteplase (TPA) increases the likelihood of FPE in basilar artery occlusion (BAO).
Wolman DN +38 more
europepmc +2 more sources