Results 11 to 20 of about 3,406 (148)

Where Evidence-Based Medicine Meets AI: Promise, Pitfalls, and Practice. [PDF]

AEM Educ Train
AEM Education and Training, Volume 10, Issue 3, June 2026.
Lee S, Davis J, Milne K, Shenvi C, Beattie LK, Wegman M, Melville L, Shih RD, Kane B.   +8 more
europepmc   +2 more sources

Tenecteplase Improves Door‐to‐Needle Time in Real‐World Acute Stroke Treatment

Stroke: Vascular and Interventional Neurology, 2021
Background We report the interim results of a process improvement initiative at a comprehensive stroke center in which all tPA (tissue‐type plasminogen activator)–eligible patients were given tenecteplase for acute ischemic stroke.
Jillian Hall, Jesse M. Thon, Mark Heslin, Lauren Thau, Terri Yeager, Taylor Siegal, Nicholas Vigilante, Scott Kamen, Justin Tiongson, Tudor G. Jovin, James E. Siegler   +10 more
doaj   +1 more source

Tenecteplase vs. alteplase for acute ischemic stroke: a systematic review

International Journal of Emergency Medicine, 2022
Introduction Thrombolysis for acute ischemic stroke (AIS) with alteplase is the currently approved therapy for patients who present within 4.5 h of symptom onset and meet criteria.
Neha Potla, Latha Ganti
doaj   +1 more source

Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background In this subanalysis of the TEMPO‐2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke and ...
Amy Y. X. Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia S. Field, Philip A. Barber, Philip M. C. Choi, Brian Buck, Timothy Kleinig, Carlos A. Molina, Bruce C. V. Campbell, Ramana Appireddy, Keith W. Muir, Michael D. Hill, Shelagh B. Coutts   +13 more
doaj   +1 more source

Enhancement of Tenecteplase Thrombolytic Actions Ex Vivo and In Vivo by Deoxyribonuclease I

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to investigate the phenomenon of thrombolysis resistance in tenecteplase and its underlying causes and evaluate whether DNase‐1 (deoxyribonuclease I) targeting neutrophil extracellular traps (NETs) could enhance the thrombolytic ...
Shuhan Xu, Zhiyong Yang, Jinyu Jia, Shijun Zhang, Shengming Huang, Liang Zhang, Min Guan, Guobing Chen, Xinyi Leng, Li’an Huang   +9 more
doaj   +1 more source

Tenecteplase versus alteplase for acute ischaemic stroke in the elderly patients: a post hoc analysis of the TRACE-2 trial

Stroke and Vascular Neurology
Background The benefit–risk profile of tenecteplase in the elderly patients with acute ischaemic stroke (AIS) is uncertain. We sought to investigate the efficacy and safety of 0.25 mg/kg tenecteplase compared with alteplase for AIS patients aged ≥80 ...
Bruce C V Campbell, Yongjun Wang, Zixiao Li, Yunyun Xiong, Yuesong Pan, Lee H Schwamm, Shuya Li, Mengxing Wang, Na Wu, Liyuan Wang, Manjun Hao, Zhixin Cao, Chunmiao Duan, Shuangzhe Wu   +13 more
doaj   +1 more source

Tenecteplase in Pulmonary Embolism Patients: A Meta-Analysis and Systematic Review

Frontiers in Medicine, 2022
ObjectiveTo assess the efficacy and safety of tenecteplase in patients with pulmonary embolism (PE).MethodsWe completed the literature search on May 31, 2021 using PubMed, EMBASE and the Web of Science.
Zhu Zhang, Zhu Zhang, Zhu Zhang, Zhu Zhang, Linfeng Xi, Linfeng Xi, Linfeng Xi, Linfeng Xi, Linfeng Xi, Shuai Zhang, Shuai Zhang, Shuai Zhang, Shuai Zhang, Yunxia Zhang, Yunxia Zhang, Yunxia Zhang, Yunxia Zhang, Guohui Fan, Guohui Fan, Guohui Fan, Guohui Fan, Xincao Tao, Xincao Tao, Xincao Tao, Xincao Tao, Qian Gao, Qian Gao, Qian Gao, Qian Gao, Wanmu Xie, Wanmu Xie, Wanmu Xie, Wanmu Xie, Peiran Yang, Zhenguo Zhai, Zhenguo Zhai, Zhenguo Zhai, Zhenguo Zhai, Chen Wang, Chen Wang, Chen Wang, Chen Wang, Chen Wang, Chen Wang   +43 more
doaj   +1 more source

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes, Leonardo Cruz‐Criollo, Eric Kontowicz, Marta Olivé‐Gadea, Francesco Diana, Johannes Kaesmacher, Adnan Mujanovic, Serdar Geyik, Songul Senadim, Amedeo Cervo, Andrea Salcuni, Mariangela Piano, Manuel Moreu, Alfonso López‐Frías, Ameer E. Hassan, Samantha Miller, Elena Zapata‐Arriaza, Asier de Albóniga‐Chindurza, Mauro Bergui, Stefano Molinaro, João André Sousa, Fábio Gomes, João Sargento‐Freitas, Andrea Alexandre, Alessandro Pedicelli, Jeremy Hofmeister, Paolo Machi, Luca Scarcia, Erwah Kalsoum, Jose Amorim, Torcato Meira, Leonardo Renieri, Francesco Capasso, Daniele Romano, Eduardo Bárcena‐Ruiz, David Seoane, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Catarina Perry da Câmara, Anderson Brito, Nashwa Abdelhakim, Isabel Fragata, Dileep R. Yavagal, Jude H. Charles, Jose Rodriguez Castro, Pedro Vega, Atilla Özcan Özdemir, Zehra Uysal Kocabaş, Stanislas Smajda, Sadiq Al Salman, Jane Khalife, Tudor G. Jovin, Francesco Biraschi, Francesca Richetti, Pedro Castro, Luis Albuquerque, Adnan Siddiqui, Vinay Jaikumar, Pedro Navia, Nikolaos Ntoulias, Marios Psychogios, Mariano Velo, Joaquín Zamarro, Gonzalo de Paco, Yazan Ashouri, Mohammad AlMajali, Juan F. Arenillas, Alicia Sierra, Michele Romoli, João Pedro Marto, Shadi Yaghi, Marc Ribo, Alejandro Tomasello, Manuel Requena, Santiago Ortega‐Gutierrez   +75 more
wiley   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Intravenous Thrombolysis Combined With Endovascular Treatment Versus Endovascular Treatment Alone in Acute Ischemic Stroke due to Tandem Lesions: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 16, Issue 8, August 2026.
Our systematic review and meta‐analysis evaluate whether intravenous thrombolysis (IVT) plus endovascular therapy (EVT) outperforms EVT alone in patients with acute ischemic stroke due to tandem lesions. Pooled data from nine studies involving 1756 patients demonstrate that IVT + EVT is associated with significantly higher rates of functional ...
Wenqian Wei, Chongxu Zhong, Jian Tang, Liufei Chen, Kunlong Yao, Liyong Li, Shengliang Shi, Yueling Zhang, Jian Zhang   +8 more
wiley   +1 more source