Intravenous Tenecteplase Compared With Alteplase for Acute Ischemic Stroke in Canada (AcT): Bridging the Gap From Academia to Regulatory Approval. [PDF]
Stroke Vasc Interv NeurolPeter N +9 more
europepmc +2 more sources
Frontiers in Neurology, 2023 BackgroundThe optimal dose of tenecteplase vs. alteplase for acute ischemic stroke (AIS) has yet to be established. Therefore, we included the latest randomized controlled trials (RCT) to assess the efficacy and safety of different doses of tenecteplase ...
Huo Liang +8 more
doaj +1 more source
Tenecteplase Improves Door‐to‐Needle Time in Real‐World Acute Stroke Treatment
Stroke: Vascular and Interventional Neurology, 2021 Background We report the interim results of a process improvement initiative at a comprehensive stroke center in which all tPA (tissue‐type plasminogen activator)–eligible patients were given tenecteplase for acute ischemic stroke.
Jillian Hall +10 more
doaj +1 more source
Age-dependent effect of thrombolytics on likelihood of National Institutes of Health Stroke Scale improvement in minor strokes. [PDF]
IbrainThere is mixed evidence regarding thrombolytics for minor stroke (NIHSS ≤ 5) patients, particularly across different subpopulations. There is an association between age and treatment response to thrombolytic therapy; there is an age‐dependent effect of degree of NIHSS improvement in response to thrombolytic treatment, particularly with tenecteplase ...
Thomas T +13 more
europepmc +2 more sources
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]
, 2017 Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat +6 more
core +3 more sources
Letter to the Editor, Regarding "Comparative Efficacy and Safety of Different Tenecteplase Doses With Alteplase in Acute Ischemic Stroke: A Systematic Review With Pairwise and Network Meta-Analysis to Determine the Optimal Dose" Recently Published by Waseem and Colleagues. [PDF]
Brain BehavBrain and Behavior, Volume 15, Issue 11, November 2025.
Frol S, Zupan M, Papanagiotou P.
europepmc +2 more sources
Response by Bivard et al to letter regarding article, "Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials" [PDF]
, 2017 No abstract ...
Bivard, Andrew +2 more
core +1 more source
Neuroimaging as a selection tool and endpoint in preclinical and clinical trials [PDF]
, 2016 Standard imaging in acute stroke enables the exclusion of non-stroke structural CNS lesions and cerebral haemorrhage from clinical and pre-clinical ischaemic stroke trials. In this review, the potential benefit of imaging (e.g., angiography and penumbral
Macrae, I. Mhairi, Muir, Keith W.
core +2 more sources
No space Left for Intravenous thrombolysis in acute stroke [PDF]
, 2016 Recent successful clinical trials of endovascular thrombectomy for large artery ischaemic stroke have established the value of this treatment modality as an adjunct to intravenous thrombolysis, not as an alternative: thrombectomy delivery was undertaken ...
Muir, Keith
core +1 more source
Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction [PDF]
, 2013 BACKGROUNDIt is not known whether prehospital fibrinolysis, coupled with timely coronary angiography, provides a clinical outcome similar to that with primary percutaneous coronary intervention (PCI) early after acute ST-segment elevation myocardial ...
Armstrong, Paul W. +22 more
core +1 more source