Results 41 to 50 of about 7,183 (232)

Tenecteplase Versus Alteplase for First‐Pass Reperfusion in Basilar Artery Occlusion Stroke Thrombectomy

Annals of Neurology, EarlyView.
Objective The first‐pass effect (FPE), defined as excellent reperfusion after a single attempt, is associated with improved outcomes in large vessel occlusion stroke. We evaluated whether intravenous tenecteplase (TNK) compared with alteplase (TPA) increases the likelihood of FPE in basilar artery occlusion (BAO).
Dylan N. Wolman, Rahul R. Karamchandani, Sina Hemmer, Tyler M. Bielinski, Nitin Goyal, Jeremy B. Rhoten, Mahesh V. Jayaraman, Christian T. Sidebottom, Bradley A. Gross, Alhamza R. Al‐Bayati, Mohamed F. Doheim, Matthew K. Tobin, Anoop Chinthala, Avi Gajjar, Justin Mascitelli, Matthew R. Webb, Jan‐Karl Burkhardt, Kyle W. Scott, Visish Srinivasan, Daniel Tonetti, Manisha Koneru, David J. Altschul, Dhrumhil Vaishnav, Sumeet Multani, Thana Theofanis, William J. Ares, Je Yeong Sone, Ramin Zand, Sasan Bahrami, Jiang Li, Gary Defilipp, Dale Strong, Radmehr Torabi, Krisztina Moldovan, Clemens M. Schirmer, Alexandra R. Paul, Bradley N. Bohnstedt, Raul G. Nogueira, Philipp Hendrix   +38 more
wiley   +1 more source

Tenecteplase compared to alteplase in real-world outcome: A Swedish Stroke Register study

Upsala Journal of Medical Sciences
Background: Tenecteplase is increasingly used off-label as an alternative to alteplase for ischemic stroke thrombolysis. Our aim was to evaluate the safety of tenecteplase versus alteplase in comprehensive real-world data.
Mikael Skärlund, Signild Åsberg, Marie Eriksson, Erik Lundström   +3 more
doaj   +1 more source

Data science of stroke imaging and enlightenment of the penumbra. [PDF]

, 2015
Imaging protocols of acute ischemic stroke continue to hold significant uncertainties regarding patient selection for reperfusion therapy with thrombolysis and mechanical thrombectomy.
Liebeskind, David S, Nour, May, Scalzo, Fabien   +2 more
core   +2 more sources

Revisiting Incomplete Tissue‐Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke

Annals of Neurology, EarlyView.
Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue‐level reperfusion, distinct from visually identifiable distal occlusion on digital‐subtraction angiography, remains a significant challenge.
Yue Qiao, Adrien Ter Schiphorst, Yi Xu, Jean‐Claude Baron, Wenbo Zhao   +4 more
wiley   +1 more source

Comprehensive Review of Tenecteplase for Thrombolysis in Acute Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Although intravenous thrombolysis with alteplase remains the primary treatment for acute ischemic stroke, tenecteplase has shown potential advantages over alteplase.
Liyuan Wang, Manjun Hao, Na Wu, Shuangzhe Wu, Marc Fisher, Yunyun Xiong   +5 more
doaj   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, Volume 16, Issue 2, Page 314-330, February 2026.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Tenecteplase thrombolysis for stroke up to 24 hours after onset with perfusion imaging selection: the umbrella phase IIa CHABLIS-T randomised clinical trial

Stroke and Vascular Neurology
Background The performance of intravenous tenecteplase in patients who had an acute ischaemic stroke with large/medium vessel occlusion or severe stenosis in an extended time window remains unknown.
Yilong Wang, Qiang Dong, Yi Sui, Leonid Churilov, Gang Li, Xiaoyu Zhou, Jin Zhang, Yu Geng, Hong-Qiu Gu, Danhong Wu, Longting Lin, Ying Guo, Xiaofei Yu, Mark Parsons, Yuwu Zhao, Yangmei Chen, Xin Cheng, Lumeng Yang, Jianhong Yang, Lan Hong, Yifeng Ling, Xueyuan Liu, Qijin Zhai, Liandong Zhao, Fan Gong   +24 more
doaj   +1 more source

Creation of Tenecteplase-Producing CHO Cell Line Using Site-Specific Integrase from the Phage φC31 [PDF]

Cell Journal, 2010
Objective: The aim of this study was to produce a stable CHO cell line expressing tenecteplase.Materials and Methods: In the first step, the tenecteplase coding sequence was clonedin a pDB2 vector containing attB recognition sites for the phage φC31 ...
Khadijeh Karbalaie, Mohammad Reza Mofid, Mohammad Hossain Nasr Esfahani, Michele P. Calos, Kianoush Dormiani, Pharm, Fereshteh Karamali, Kamran Ghaedi, Mahboobeh Forouzanfar, Yahya Khazaie, Pharm   +8 more
doaj  

Prospective Evaluation of Serial Biomarkers in Patients With Intermediate High Risk Acute Pulmonary Embolism: A Single Center Proof‐of‐Concept Study

Pulmonary Circulation, Volume 16, Issue 1, January 2026.
ABSTRACT Patients diagnosed with intermediate high‐risk pulmonary embolism (IHRPE) are at significant risk for clinical deterioration during hospitalization; however, clinical tools to identify which patients will worsen are imprecise. We designed a proof‐of‐concept, single‐center prospective study to assess IHRPE patients (using 2019 ESC criteria ...
Hilamber Subba, Ariel McKenna, John Gilboy, Jacob Gelman, Jessica Evans, Alex Smith, James Kerney, Joel A. Wirth   +7 more
wiley   +1 more source