Results 61 to 70 of about 5,941 (179)

Implementation of a Tenecteplase Protocol for Treatment of Acute Ischemic Stroke in a Health System

INNOVATIONS in Pharmacy
Purpose. Alteplase is the standard of care for intravenous thrombolytic treatment of acute ischemic stroke, but recent evidence suggests that tenecteplase may be as safe and efficacious. The purpose of this study was to evaluate the direct cost savings,
Alexis Pace, Maya Wai, Ethan Frye
doaj  

Alteplase- and Tenecteplase-Related Errors and Risk Mitigation Strategies in the Treatment of Acute Ischemic Stroke: A Study of Event Reports From 52 Hospitals

Patient Safety
# Background Alteplase and tenecteplase are thrombolytic agents used to treat patients with acute ischemic stroke (AIS). Despite the convenient bolus dosing of tenecteplase, its off-label use for AIS creates new patient safety challenges that are ...
Myungsun Ro, Matthew A. Taylor, Rebecca Jones   +2 more
doaj   +1 more source

Heart to Heart, May 2012 [PDF]

, 2012
Heart to Heart is a publication on new heart disease and stroke information and other related topics by the Department of Public ...

core  

Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial

Stroke and Vascular Neurology
Background In ischaemic stroke, minor deficits (National Institutes of Health Stroke Scale (NIHSS) ≤5) at presentation are common but often progress, leaving patients with significant disability.
Dar Dowlatshahi, Mohammed A Almekhlafi, Tolulope Sajobi, Aleksandra Pikula, Ashfaq Shuaib, Alexandre Y Poppe, Richard H Swartz, Fouzi Bala, Ibrahim Alhabli, Aleksander Tkach, Heather Williams, Shelagh B Coutts, Nishita Singh, Anurag Trivedi, Andrew Demchuk, Gary Hunter, Brian H Buck, Faysal Benali, Bijoy Menon, MacKenzie Horn, Radhika Nair, Thalia Field, Mahesh Kate, Negar Asdaghi, Robert Sarmiento, Ayoola Ademola, Houman Khosravani, Herbert Alejandro Manosalva Alzate, Luciana Catanese   +28 more
doaj   +1 more source

Outpatient treatment of low-risk venous thromboembolism with monotherapy oral anticoagulation: patient quality of life outcomes and clinician acceptance [PDF]

, 2016
BACKGROUND: Oral monotherapy anticoagulation has facilitated home treatment of venous thromboembolism (VTE) in outpatients. OBJECTIVES: The aim of this study was to measure efficacy, safety, as well as patient and physician perceptions produced by
Beam, Daren M., Kahler, Zachary P., Kline, Jeffrey A.   +2 more
core   +2 more sources

Risk of angioedema and thrombolytic therapy among stroke patients: An analysis of data from the FDA Adverse Event Reporting System database

Neurotherapeutics
The angioedema risk may vary among stroke patients receiving different thrombolytic agents. This study aimed to investigate the angioedema risk associated with different thrombolytic agents and to identify associated risk factors.
Hunong Xiang, Yu Ma, Xiaochao Luo, Jian Guo, Minghong Yao, Yanmei Liu, Ke Deng, Xin Sun, Ling Li   +8 more
doaj   +1 more source

Ethnic Differences in the Safety and Efficacy of Tenecteplase Versus Alteplase for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis [PDF]

Journal of Stroke
Background and Purpose Tenecteplase is a thrombolytic agent with pharmacological advantages over alteplase and has been shown to be noninferior to alteplase for acute ischemic stroke in randomized trials.
Jin Hean Koh, Claire Yi Jia Lim, Lucas Tze Peng Tan, Ching-Hui Sia, Kian Keong Poh, Vijay Kumar Sharma, Leonard Leong Litt Yeo, Andrew Fu Wah Ho, Teddy Wu, William Kok-Fai Kong, Benjamin Yong Qiang Tan   +10 more
doaj   +1 more source

Design of a recombinant tissue plasminogen activator production plant [PDF]

, 2013
Conté: Part 1, General vision and presentation of the plant / Ferran Vila. Part 2, Technical characteristics of the process / Carla Sánchez.
Roca, Ramon, Sánchez, Carla, Universitat Autònoma de Barcelona. Facultat de Biociències, Vila, Ferran   +3 more
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Efficacy and Safety of Intravenous Tenecteplase Before Endovascular Thrombectomy for Acute Ischemic Stroke: The Multicenter, Randomized, BRIDGE‐TNK Trial Protocol

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and endovascular thrombectomy alone in stroke.
Zhongming Qiu, Fengli Li, Dongjing Xie, Guangxiong Yuan, Thanh N. Nguyen, Kai Zhou, Raul G. Nogueira, Jeffrey L. Saver, Bruce C.V. Campbell, Gregory W. Albers, Hongfei Sang, Linyu Li, Yan Tian, Zhaoyou Meng, Duolao Wang, Wenjie Zi, Qingwu Yang   +16 more
doaj   +1 more source

Evidence Synthesis for Decision Making 4:Inconsistency in Networks of Evidence Based on Randomized Controlled Trials [PDF]

, 2013
Inconsistency can be thought of as a conflict between “direct” evidence on a comparison between treatments B and C and “indirect” evidence gained from AC and AB trials.
Ades, A E, Caldwell, Deborah M, Dias, Sofia, Lu, Guobing, Sutton, Alex J., Welton, Nicky J   +5 more
core   +1 more source