Results 71 to 80 of about 34,537 (182)

Barriers to Hepatitis B Treatment: A Multicentre Cross‐Sectional Registry and Survey Study by the Canadian Hepatitis B Network

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Background & Aims Chronic hepatitis B (CHB) remains a leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide, yet treatment uptake is suboptimal even in high‐resource settings. This pan‐Canadian study aimed to quantify treatment gaps within the Canadian Hepatitis B Network (CanHepB) Registry, compare characteristics of ...
Hin Hin Ko, Jordyn Vienneau, Curtis L. Cooper, Pam Crotty, Stephen E. Congly, Mayur Brahmania, Alnoor Ramji, Erin Kelly, Angela M. Crawley, Karen Doucette, Vanessa Meier‐Stephenson, Mang Ma, Scott K. Fung, David K. Wong, Jordan Feld, Nabiha Faisal, Kelly Kaita, Carla Osiowy, Magdy Elkhashab, Edward Tam, Alexander Wong, Robert Bailey, Philip Wong, Giada Sebastiani, Tianyan Chen, Brian Conway, David Truong, Keith Tsoi, Carmine Nudo, Julie Zhu, Sébastien Poulin, Abdel‐Aziz Shaheen, Carla S. Coffin   +32 more
wiley   +1 more source

Acute kidney injury KDIGO stage 2 to 3 in HIV-positive patients treated with cART – a case series over 11 years in a cohort of 1,153 patients

Swiss Medical Weekly, 2015
OBJECTIVES: We aimed to explore acute kidney injury (AKI) Kidney Disease Improving Global Guidelines (KDIGO) stage 2 to 3 in a cohort of antiretroviral treated HIV-infected individuals.
Mario Kurz, Felix Burkhalter, Michael Dickenmann, Helmut Hopfer, Michael Mayr, Luigia Elzi, Manuel Battegay   +6 more
doaj   +1 more source

The Case of a 40‐Year‐Old Man With New‐Onset Status Epilepticus in the Setting of HIV Infection

Annals of Clinical and Translational Neurology, Volume 13, Issue 8, Page 1736-1739, August 2026.
ABSTRACT A 40‐year‐old man from Andhra Pradesh in India, while on regular antiretroviral treatment (ART) for long‐standing HIV infection presented with a 1‐day history of new‐onset status epilepticus. CT and MRI brain showed multifocal cerebral ring lesions, some of which demonstrated characteristic ‘hole‐with‐a‐dot’ sign.
Vadde Akhil, Ramachandiran Nandhagopal
wiley   +1 more source

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2949-2959, August 2026.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

Is there Emergence of Clinical HBV Resistance Under Long-Term HBV Combination Therapy? A Challenging Case Report

Viruses, 2010
A first case of clinical tenofovir (TDF) HBV resistance in an HIV/HBV coinfected patient who developed an acute flare of hepatitis B is reported. The clinical course was accompanied by signs of acute liver failure after being on successful HBV treatment ...
Jürgen Kurt Rockstroh, Jan van Lunzen, Stefan Schmiedel, Hüseyin Sirma, Christian Noah, Knud Schewe, Oliver Schildgen   +6 more
doaj   +1 more source

Diabetic Striatopathy in a Middle‐Aged African Woman With Poorly Controlled Type 2 Diabetes Mellitus and HIV Coinfection—A Case Report

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Diabetic striatopathy is a reversible cause of acute chorea occurring in patients with poorly controlled diabetes mellitus, including those even with complex comorbidities like HIV. Timely neuroimaging and prompt metabolic correction are crucial, emphasizing the need for high clinical suspicion.
Kojo Awotwi Hutton‐Mensah, Francis Asante Baadu, Allswell Ackon, Alfred Opata, Ranis Anamon Amon, Frank Micah   +5 more
wiley   +1 more source

Bard1‐Mediated Regulation of Hnrnpa2b1 Ubiquitination and Protein Stability Contributes to Neuronal Ferroptosis and Cognitive Dysfunction Following Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Bard1‐mediated ubiquitination of Hnrnpa2b1 in mice with PSCI destabilizes Sptbn2, which prevents the membrane translocation of Slc7a11 and reduces cystine uptake. This disruption of antioxidant defense triggers ferroptosis in hippocampal neurons, highlighting a novel molecular pathway linking post‐stroke cognitive impairment to ferroptosis of ...
Tuming Li, Tianyi Rong, Zuoting Shen, Zhenyu Wei, Deyan Chen, Ping Zhong, Li Cao   +6 more
wiley   +1 more source

Effect of Late Second to Early Third Trimester of Pregnancy on the Activity of Renal Organic Anion Transporters (OAT1 and OAT3): A Biomarker Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 465-474, August 2026.
Pregnant individuals take drugs throughout pregnancy and many of these drugs (e.g., antivirals, antibiotics) are eliminated by renal organic anion transporters (OAT) 1 and OAT3. In vivo studies with OAT1/3 substrate drugs suggest that pregnancy increases renal OAT1/3 activities by 1.5‐ to 1.8‐fold.
Aarzoo Thakur, Jashvant D. Unadkat, Emily E. Fay, Nina Isoherranen, Mary F. Hebert   +4 more
wiley   +1 more source

Vector‐based comparison as a novel framework for assessing multi‐endpoint clinical trials: Applications to actual data

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Multi‐endpoint clinical trials face long‐standing statistical challenges. Vector‐based comparison (VBC) decomposes endpoints into orthogonal components. Applied to five clinical trials, it reduced confidence‐interval widths by about 50%, indicating higher statistical power, without altering the clinical meaning of endpoints.
Maria Kokkali, Vangelis D. Karalis
wiley   +1 more source

Modelling the 5‐Year Impact of Twice‐Yearly Injectable Lenacapavir for HIV Pre‐Exposure Prophylaxis in the United States

Journal of the International AIDS Society, Volume 29, Issue 8, August 2026.
Abstract Introduction The impact of pre‐exposure prophylaxis (PrEP) on the US HIV‐1 epidemic has not been fully maximized, potentially due to challenges in uptake, coverage, adherence and consistent use. Following the FDA (Food and Drug Adminstration) approval of twice‐yearly lenacapavir, epidemiological projections are needed to understand the ...
Mia Moore, Serin Lee, Laura Matrajt, Sarah E. Stansfield, Li Tao, Juan Yang, Dylan Mezzio, James Jarrett, JeanPierre Coaquira Castro, Alice Hsiao, Woodie Zachry, Dobromir Dimitrov   +11 more
wiley   +1 more source