Results 71 to 80 of about 19,810 (202)

Dyslipidemia in chronic hepatitis B patients on tenofovir alafenamide: Facts and puzzles [PDF]

Clinical and Molecular Hepatology, 2022
Hung-Yao Lin, Tai-Chung Tseng
doaj   +1 more source

Fanconi Syndrome Due to Tenofovir Disoproxil Fumarate in a Patient with Chronic Hepatitis B Induced Cirrhosis: A Case Report

Case Reports in Clinical Practice
We present a 63-year-old woman with chronic hepatitis B. The patient has a history of cirrhosis due to chronic hepatitis B and is under treatment with Tenofovir disoproxil fumarate.
Milad Khodabakhshi, Behshad Pazooki
doaj   +1 more source

Dosing HIV integrase inhibitors with enzyme inducers: Convenience vs. control?

British Journal of Clinical Pharmacology, EarlyView.
Catia Marzolini, Saye Khoo
wiley   +1 more source

Hepatitis B in Organ Transplantation—Current Evidence and Clinical Gaps

Transplant Infectious Disease, EarlyView.
ABSTRACT Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through immunization. Despite this, HBV remains a leading cause of chronic liver disease globally, affecting over 250 million people.
Oscar A. Fernandez‐Garcia, Britta L. Hirsch, Irene A. Abela, Karen E. Doucette   +3 more
wiley   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Investigating a semi-continuous synthetic pathway for the preparation of the antiretroviral drugs tenofovir disoproxil and tenofovir alafenamide [PDF]

, 2021
Dissertation (MSc (Chemistry))--University of Pretoria, 2021.This dissertation details the investigation of the synthetic pathway of the antiretroviral drug, tenofovir, and its prodrug forms tenofovir disoproxil and tenofovir alafenamide, in attempt to ...

core  

Tenofovir alafenamide [PDF]

Reactions Weekly, 2020
  +4 more sources

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Safety, Tolerability and Antiviral Activity of GST‐HG131 in Chronic Hepatitis B: A Randomized, Double‐Blind Phase IIa Study

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background and Aims Chronic hepatitis B (CHB) remains a major global health burden. Current therapies rarely achieve a functional cure due to low rates of HBsAg clearance, the persistence of the viral replication template—covalently closed circular DNA (cccDNA)—and the need for lifelong treatment.
Yuming Guo, Zhe Xu, Yuanyuan Li, John Mao, Tianxiang Zhang, Yonggang Li, Fanping Meng, Junliang Fu, Dong Ji, Yingjie Ji, Yongqian Cheng, Min Zhang, Xin Zhang, Ying Sun, Zuxiong Huang, Dachuan Cai, Wenqiang Wu, Wenhao Yan, Xiuping Yan, Guoping Li, Jinlin Hou, George Zhang, Fu‐Sheng Wang   +22 more
wiley   +1 more source

Study flow.

, 2022
TDF, tenofovir-disoproxil-fumarate; TAF, tenofovir alafenamide.
Mitsuteru Natsuizaka (681265), Kenichi Morikawa (416434), Goki Suda (5093396), Taku Shigesawa (10213675), Shuichi Miyamoto (2950794), Naoki Kawagishi (6111821), Yoshiya Yamamoto (9301387), Satoshi Abiko (11978946), Masato Nakai (122330), Kenji Kinoshita (22835), Osamu Maehara (424075), Naoya Sakamoto (205073), Megumi Kimura (6111824), Koji Ogawa (2571607), Kazuharu Suzuki (6111827), Ryo Sugiura (11978949), Ren Yamada (10213681), Takuya Sho (6111839), Takashi Kitagataya (10213687), Masatsugu Ohara (5511236)   +19 more
core   +1 more source