Results 81 to 90 of about 19,810 (202)

Experimental and Pharmacoinformatic Studies Reveal Allium cepa L. Extract‐Mediated Modulation of Hepatitis B Virus Associated Inflammatory Pathways via Quercetin Glucoside Derivatives

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
HBV infection causes chronic inflammation, fibrosis, and hepatocellular carcinoma despite effective antiviral therapy. This study evaluated methanolic Allium cepa extract using in vitro and computational approaches. The extract reduced HBsAg and HBeAg, enhanced Tenofovir alafenamide activity, and modulated inflammatory markers.
Swarup S. Gujarathi, Darasaguppe R. Harish, Vishal S. Patil, Adilmehadi Karikazi, Faizan A. Beerwala, Jagdish Chand, Gaurav Kumar Sahu, Sunil S. Jalalpure   +7 more
wiley   +1 more source

Improved Bone Safety of Tenofovir Alafenamide Compared to Tenofovir Disoproxil Fumarate Over 2 Years in Patients With Chronic HBV Infection.

, 2018
Long-term use of tenofovir disoproxil fumarate (TDF) reduces bone mineral density (BMD). Tenofovir alafenamide (TAF), a new prodrug of tenofovir, has shown non-inferior efficacy to TDF in patients with chronic hepatitis B virus (HBV) infection, with ...
François Habersetzer, Tuan T. Nguyen, Peng, Cheng-Yuan, Abdurakhmanov D, Fung S, Wang, Hongyuan, Brown, Todd T., Lau, Audrey H., Nguyen, Tuan T., Maurizia R. Brunetto, Inokuma, T, Ramji, A, Flaherty JF, Asahina, Yauhiro, Gaggar A, Brunetto, Maurizia R., Suri, Vithika, Chan, Henry Lik-Yen, Inokuma T, Wan-Long Chuang, Chan HL, Gaggar, Anuj, Chuang, WL, Chuang WL, G. Mani Subramanian, Henry Lik-Yuen Chan, Nguyen, Tuan T, Habersetzer F, Wai-Kay Seto, Brunetto, Maurizia R, Fehmi Tabak, Habersetzer, François, Ikeda, F, Santantonio, TA, Stanciu C, Suri, V, Asahina, Yasuhiro, Wang, H, Vithika Suri, John F. Flaherty, Flaherty, John F, Cheng-Yuan Peng, Santantonio TA, Gaggar, A, Seto, Wai-Kay, Tabak F, Carol Stanciu, Brunetto, MR, Suri V, Tabak, F, Brown TT, Lau, AH, Flaherty, John F., Abdurakhmanov, Dzhamal, Asahina Y, Wang H, Teresa Antonia Santantonio, Flaherty, JF, Stanciu, Carol, Tetsuro Inokuma, Hongyuan Wang, Chuang, Wan-Long, Chan, Henry Lik-Yuen, Fung, S, Santantonio, Teresa Antonia, Todd T. Brown, Audrey H. Lau, Nguyen, TT, Scott Fung, Ikeda F, Yasuhiro Asahina, Abdurakhmanov, D, Tabak, Fehmi, Peng CY, Mukewar, Shrikant, Habersetzer, F, Alnoor Ramji, Subramanian GM, Ramji, Alnoor, Peng, CY, Subramanian, G. Mani, Nguyen TT, Subramanian, GM, Anuj Gaggar, Lau, Audrey H, Fusao Ikeda, Subramanian, G Mani, Fung, Scott, Shrikant Mukewar, Asahina, Y, Ramji A, Brown, Todd T, Stanciu, C, Seto WK, Mukewar S, Mukewar, S, Chan, HL, Dzhamal Abdurakhmanov, Ikeda, Fusao, Lau AH, Brown, TT, Brunetto MR, Seto, WKW, Inokuma, Tetsuro   +103 more
core   +1 more source

Population Modeling Highlights Drug Disposition Differences Between Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate in the Blood and Semen [PDF]

, 2019
Understanding antiretroviral disposition in the male genital tract, a distinct viral compartment, can provide insight for the eradication of HIV. Population pharmacokinetic modeling was conducted to investigate the disposition of tenofovir disoproxil ...
Nelson, J.A.E., Blake, K., Chen, J., Greene, S.A., Prince, H.M.A., Gay, C.L., Sykes, C., Cohen, M.S., Schauer, A.P., Dumond, J.B.   +9 more
core   +1 more source

Hepatitis B Virus Reactivation after Switch to Cabotegravir/Rilpivirine in Patient with Low Hepatitis B Surface Antibody

Emerging Infectious Diseases
A patient in Japan with HIV began antiretroviral therapy because of acute hepatitis B virus (HBV) 15 years ago, with low hepatitis B surface antibody, and experienced breakthrough HBV reactivation 4 months after switching from bictegravir/emtricitabine ...
Eisuke Adachi, Ayako Sedohara, Kotaro Arizono, Kazuaki Takahashi, Amato Otani, Yoshiaki Kanno, Makoto Saito, Michiko Koga, Hiroshi Yotsuyanagi   +8 more
doaj   +1 more source

Role of tenofovir alafenamide in the jungle of antiretroviral prescription

, 2017
In the fifth paragraph of the original published version of this article the third sentence was incorrect. The correct sentence is: Fromthis perspective, the impact of tenofovir alafenamide in the HIV treatment armamentarium goes beyond its capacity to ...
Guaraldi G., Giovanni Guaraldi
core   +1 more source

Renal function change after switching tenofovir disoproxil fumarate for tenofovir alafenamide in the HIV-positive patients of a metropolitan sexual health service

AIDS Research and Therapy, 2019
Background Tenofovir disoproxil fumarate (TDF) is widely used in the management of HIV-infection, but has been associated with renal impairment in a small proportion of patients.
Dane Turner, Douglas Drak, Catherine C. O’Connor, David J. Templeton, David M. Gracey   +4 more
doaj   +1 more source

Distinct Lipidomic Profiles between People Living with HIV Treated with E/C/F/TAF or B/F/TAF: An Open-Label Prospective Cohort Study

Infectious Diseases and Therapy
Introduction Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) has been increasingly replaced by bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in the treatment of human immunodeficiency virus (HIV) owing to its more ...
Zhikai Wan, Junwei Su, Xueling Zhu, Xiang Liu, Yongzheng Guo, Dairong Xiang, Xiaotang Zhou, Xiaorong Peng, Ran Tao, Qing Cao, Guanjing Lang, Ying Huang, Biao Zhu   +12 more
doaj   +1 more source

Hepatitis B Management in the Middle East: A Narrative Review of Current Antiviral Treatments

Gastrointestinal Disorders
Introduction: Chronic hepatitis B (CHB) is a significant public health issue worldwide, especially in the Middle East region. Around 8% to 20% of patients with CHB develop cirrhosis, which may progress to hepatocellular carcinoma.
Hannah Beck, Nishaanth Dalavaye, Kalaikshiga Kengadaran, Mosammath Monira Khatun, Ria Hitesh Patel, Taif Al-Rubaye, Laith Alrubaiy   +6 more
doaj   +1 more source

Switching tenofovir disoproxil fumarate to tenofovir alafenamide results in a significant decline in parathyroid hormone levels: uncovering the mechanism of tenofovir disoproxil fumarate-related bone loss?

, 2019
: An increasing number of patients have been switched from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide because of its improved bone safety profile, although the pathophysiological mechanism is not fully understood.
Mudrikova, Tania, Thielen, Matheus A J, Hoepelman, Andy I M, Arends, Joop E, Van Welzen, Berend J, MS Vasculaire & Endocrinologie, MS Infectieziekten, Circulatory Health, Infection & Immunity   +8 more
core  

Tenofovir alafenamide versus tenofovir disoproxil fumarate: is there a true difference in efficacy and safety?

Journal of Virus Eradication, 2018
Background: Higher plasma tenofovir concentrations are associated with higher risks of renal and bone adverse events. The pharmacokinetic boosters ritonavir (RTV) and cobicistat (COBI) significantly increase plasma area under the curve (AUC ...
Andrew Hill, Sophie L. Hughes, Dzintars Gotham, Anton L. Pozniak   +3 more
doaj   +1 more source