Results 91 to 100 of about 21,293 (203)

Considerations for the Use of AAV‐based Gene Therapy in HIV‐Positive Individuals With Haemophilia

Haemophilia, Volume 32, Issue 3, Page 584-592, May/June 2026.
ABSTRACT Introduction There is a high prevalence of human immunodeficiency virus (HIV) infection among the haemophilia community due to treatment in the 1970s and 1980s with contaminated clotting factor. Lifelong treatment regimens for haemophilia and HIV are burdensome alone and pose a particular challenge for individuals living with both conditions ...
Jürgen K. Rockstroh, Julia C. Stingl, Marco Stadler, Anja Reichert, Heiner Wedemeyer, Johannes Oldenburg   +5 more
wiley   +1 more source

Switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate in a cohort of patients with HBV infection: A retrospective study

Journal of Clinical Virology Plus
Background: Tenofovir disoproxil fumarate (TDF) as first-line therapy for chronic HBV infection is related to nephrotoxicity. Tenofovir alafenamide fumarate (TAF) has been approved with a similar virological and serological response, but lower toxicity ...
Giacomo Stroffolini, Valentina Dodaro, Amedeo De Nicolò, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio, Lucio Boglione   +6 more
doaj   +1 more source

The role of drug transporters in the kidney: lessons from tenofovir [PDF]

, 2014
Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients.
Moss, DM, Neary, M, Owen, A
core   +2 more sources

Achieving reimbursable PrEP is insufficient to increase and diversify the users attending community‐based services

HIV Medicine, Volume 27, Issue 5, Page 785-795, May 2026.
Abstract Objectives The reimbursement of HIV pre‐exposure prophylaxis (PrEP) in Italy was expected to increase uptake and diversify users. We assessed changes in PrEP initiation patterns before and after reimbursement at a community‐based service. Methods We conducted a monocentric retrospective cohort study that included all individuals who initiated ...
Enrico Caruso, Alessandro Tavelli, Anna De Bona, Nicoletta Frattini, Davide Moschese, Camilla Muccini, Daniele Tesoro, Alessandro Guido Soria, Alessandra Bianchi, Antonella D' Arminio Monforte, Massimo Cernuschi, Roberto Rossotti   +11 more
wiley   +1 more source

Effect of Baseline Renal Function on Tenofovir-Containing Antiretroviral Therapy Outcomes in Zambia [PDF]

, 2017
In this large cohort of human immunodeficiency virus-infected patients receiving first-line antiretroviral therapy in Zambia, individuals who started a tenofovir-containing regimen despite baseline renal dysfunction showed comparable mortality and renal ...
Calmy, Alexandra, Chi, Benjamin H., Davies, Mary-Ann, Keiser, Olivia, Mulenga, Lloyd, Musonda, Patrick, Mwango, Albert, Mweemba, Aggrey, Stringer, Jeffrey S., Vinikoor, Michael J., Wandeler, Gilles   +10 more
core  

Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women [PDF]

, 2011
The early closure of a clinical trial assessing the effectiveness of oral antiretroviral pre-exposure prophylaxis (PrEP) in women, FEM-PrEP, is a substantial setback for HIV prevention.
Abdool Karim, Angela DM Kashuba, Dumond, Grant, Karim, Lise Werner, Quarraisha Abdool Karim, Salim S Abdool Karim   +7 more
core   +2 more sources

Cost‐Effectiveness of Interventions to Improve Retention in Care for Chronic Hepatitis B in the United States

Journal of Viral Hepatitis, Volume 33, Issue 5, May 2026.
ABSTRACT Monitoring and retention in care remain suboptimal for patients diagnosed with chronic hepatitis B (CHB) infection with only a minority receiving consistent follow‐up. This study evaluates the cost‐effectiveness of interventions aimed at improving long‐term monitoring and retention in care among diagnosed CHB. A Markov model simulated outcomes
Irene Starinieri, Amit Chitnis, Robert J. Wong, Emily Yette, Hang Pham, Amy S. Tang, Samuel So, Mehlika Toy   +7 more
wiley   +1 more source

A Review and Clinical Understanding of Tenofovir: Tenofovir Disoproxil Fumarate versus Tenofovir Alafenamide

Journal of the International Association of Providers of AIDS Care, 2020
HIV is a serious chronic medical condition. Significant improvements in antiretroviral therapy have led to a transformation in its management. No curative treatment is available for HIV, and lifelong therapy is required with a combination of agents to ...
Chanie Wassner PharmD, BCCCP, BCIDP, Nicole Bradley PharmD, BCPS, BCIDP, Yuman Lee PharmD, BCIDP, AAHIVP   +2 more
doaj   +1 more source

Interactions of tenofovir, lamivudine, abacavir and didanosine in primary human cells [PDF]

, 2011
Certain triple nucleoside/tide reverse transcriptase inhibitor (NRTI) regimens containing tenofovir (TDF) have been associated with rapid early treatment failure. The mechanism is unknown, but may be at the level of drug transport.
Balimane, Bousquet, Brenner, Chandler, Cihlar, de Souza, Gallant, Gibbs, Gibbs, Giri, Hawkins, Imaoka, Janneh, Janneh, Janneh, Janneh, Kewn, Kewn, Khanlou, Maitland, Mallants, Minderman, Minuesa, Omar Janneh, Pan, Podzamczer, Robbins, Saye Khoo, Shaik, Shiraki, Storch, Tong, Turriziani, van Gelder, Wang, Wang, Waters, Weiss   +37 more
core   +2 more sources

Antiviral treatment of HBV positive pregnant women: an additional tool to reduce perinatal transmission [PDF]

, 2016
In a recent study published in New England Journal of Medicine, Pan and colleagues1 faced an important aspect for prevention of hepatitis B virus (HBV) infection: antiviral treatment with Tenofovir (TDF) during pregnancy to reduce perinatal ...
Bruni, Roberto, Ciccaglione, Anna Rita, Taliani, Gloria   +2 more
core   +1 more source