Results 81 to 90 of about 13,919 (330)

Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric developmental safety assessment presents distinct challenges in drug development. Children undergo dynamic changes in organ systems and drug disposition pathways during development, and drug‐related effects may be delayed or manifested differently than in adults.
Gilbert J. Burckart, Gelareh Abulwerdi, Christin L. Daniels, Calib Choi, Rebecca Racz, Jean‐Pierre Valentin, Kristin Ardlie, Nicholas Tatonetti, Susan Laffan, Marjory Moreau, Will Redfern, Lang Li, James J. Hickman, Rajanikanth Madabushi, Bhagwat Prasad, Lynne Yao, Paul B. Watkins   +16 more
wiley   +1 more source

Status Epilepticus and Low-Grade Glioma in the Pregnant State: Case Report and Ethical Considerations

Case Reports in Neurology
Introduction: The pregnant state may cause or exacerbate existing neurological disease. Gliomas appear to be influenced by the physiological changes that occur during pregnancy.
Andrew L. Waack, Vito M. Lucarelli, Amulya Marellapudi, Alisa Gega, Andrew J. Zillgitt, Michael D. Staudt   +5 more
doaj   +1 more source

Phase‐Change‐Activated Slippery Organogel Composite for All‐in‐One Anti‐Corrosion, Antifouling, and Self‐Cleaning

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A super‐slippery liquid‐infused composite organogel is engineered by localized interfacial grafting between hydrogel and oleogel networks, endowing the coating with a durable, multifunctional marine‐protective interface. Dynamic antifouling surfaces have emerged as a promising alternative, offering the potential for eco‐friendly and high‐performance ...
Mengsheng Xia, Chao Wang, Jiahao Ma, Jiwei Chen, Yixi Su, Junkai Gao, Weiqi Fu   +6 more
wiley   +1 more source

Developmental Exposures to Three Mammalian Teratogens Produce Dysmorphic Phenotypes in Adult Caenorhabditis elegans

Toxics
Efficient new methods are needed to support initiatives to reduce, refine, and/or replace toxicity testing in vertebrates. 5-fluorouracil (5FU), hydroxyurea (HU), and ribavirin (RV) are mammalian teratogens. Skeletal, endocrine organ, and cardiac effects
Piper Reid Hunt, Martine Ferguson, Nicholas Olejnik, Jeffrey Yourick, Robert L. Sprando   +4 more
doaj   +1 more source

Developmental Toxicity of Mycotoxin Fumonisin B₁ in Animal Embryogenesis: An Overview

Toxins, 2019
A teratogenic agent or teratogen can disturb the development of an embryo or a fetus. Fumonisin B1 (FB1), produced by Fusarium verticillioides and F. proliferatum, is among the most commonly seen mycotoxins and contaminants from stale maize and other ...
Chompunut Lumsangkul, Hsin-I Chiang, Neng-Wen Lo, Yang-Kwang Fan, Jyh-Cherng Ju   +4 more
doaj   +1 more source

Reversible Neonatal Cholestasis Following In Utero Exposure to Valproic Acid

McGill Journal of Medicine, 2020
Valproic acid (VPA) is a branched-chain carboxylic acid with broad anticonvulsant activity. Its spectrum of activity is thought to be mediated by combined molecular effects on intercellular Na+ currents, neuron K+ channels, and inhibition of gamma ...
Douglas G Chang, Martin Stein, David Sine, David Yeung, Frank Mannino   +4 more
doaj   +1 more source

The effect of antiseizure medications on the exposure to combined oral contraceptives: A systematic review and network meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objective Current recommendations for prescribing combined oral contraceptives (COCs) to people with epilepsy are often conflicting, particularly for weak inducers of cytochrome P450 3A4. We aimed to critically review the literature and compare the antiseizure medication (ASM)‐induced changes in exposure to COC components.
Hagar Cohen, Amnah Omar Mahajna, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Polymicrogyria and Congenital Parvovirus B19 Infection

American Journal of Perinatology Reports, 2011
Fetal parvovirus B19 infection causes anemia, hydrops, and pregnancy loss but is generally not considered teratogenic. Nevertheless, disturbances of neuronal migration have been described with congenital parvovirus infection.
Grant S. Schulert, William F. Walsh, Jörn-Hendrik Weitkamp   +2 more
doaj   +1 more source

Genesis of Teratogen-induced Holoprosencephaly in Mice

American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2010
Evidence from mechanical, teratological, and genetic experimentation demonstrates that holoprosencephaly (HPE) typically results from insult prior to the time that neural tube closure is completed and occurs as a consequence of direct or indirect insult ...
R. Lipinski, Elizabeth A. Godin, S. K. O'Leary-Moore, Scott E. Parnell, K. Sulik   +4 more
semanticscholar   +1 more source

Epilepsy with eyelid myoclonia beyond the classical phenotype: Longitudinal electroclinical observations in a pediatric cohort

Epileptic Disorders, EarlyView.
Abstract Objective Epilepsy with eyelid myoclonia is a childhood‐onset generalized epilepsy syndrome with variable recognition of eyelid myoclonia, eye‐closure sensitivity, and photosensitivity during follow‐up. We aimed to characterize longitudinal clinical and electroencephalographic features in pediatric epilepsy with eyelid myoclonia, focusing on ...
Hande Aygün, Alper Taşkın, Özlem Yayıcı Köken, Şenay Haspolat   +3 more
wiley   +1 more source