Results 71 to 80 of about 13,919 (330)
Scientific ReportsBecause of their developmental toxicity, some antiseizure medication (ASM) should be avoided during pregnancy. This may lead to discontinuation or switching of ASM after recognition of pregnancy, but some of these changes may be suboptimal. Trends in ASM
Maria Hoeltzenbein +4 more
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Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?
Clinical Pharmacology &Therapeutics, EarlyView.Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart +6 more
wiley +1 more source
A Recent Clinical Update on Epilepsy in Pregnancy
University of Ottawa Journal of Medicine, 2015 : Chronic diseases can have numerous effects across a person’s lifespan. Epilepsy is a chronic disease that impacts all stages of life including pregnancy.
Isabel Arroyo
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Teratogenicity and hyperprolactinemia
Indian Journal of Psychiatry, 2009 Byline: Chittaranjan. Andrade CME Questions A) Drugs should be prescribed with caution to women of childbearing age because of the risk of teratogenicity, should conception occur during treatment; this concern is particularly important when prescribing drugs that will be required for long periods, such as in the maintenance therapy of epilepsy, bipolar
openaire +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian +12 more
wiley +1 more source
Frontiers in Pediatrics, 2014 In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent this
Priscilla Pui Lam Chiu
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UJI AKTIVITAS VITAMIN A TERHADAP EFEK TERATOGEN WARFARIN PADA FETUS MENCIT PUTIH [PDF]
, 2008 ABSTRAK Telah dilakukan uji pengaruh pemberian vitamin A dalam menekan efek teratogen dari warfarin pada mencit putih. Mencit yang telah hamil diberikan vitamin A tiap dua hari secara oral dengan dosis 7,8 UI/20 g BB sebelum masa organogenesis mulai hari
Herlina, Fitri +2 more
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Clinical Pharmacology &Therapeutics, EarlyView.Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit +7 more
wiley +1 more source
Distribution of pomalidomide into semen of healthy male subjects after multiple doses
Clinical Pharmacology: Advances and Applications, 2018 Yan Li,1 Xiaomin Wang,2 Liangang Liu,3 Josephine Reyes,1 Maria Palmisano,1 Simon Zhou1 1Translational Development and Clinical Pharmacology, Celgene Corporation, Summit, NJ, USA; 2Non-Clinical Development, Celgene Corporation, Summit, NJ, USA ...
Li Y +5 more
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A Review of the Teratogenic Factors Effect on Embryo [PDF]
Journal of Advanced Biomedical Sciences, 2016 Background & Objectives: Teratology is a branch of embryology science that studies causes, mechanisms and abnormal pattern development. Embryo growth traumatic factors during pregnancy are called teratogens that some teratogens pass the placental barrier
Manzarbanoo Shojaei fard +2 more
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