Results 51 to 60 of about 13,919 (330)

The beliefs of mothers in southern Brazil regarding risk-factors associated with congenital abnormalities

Genetics and Molecular Biology, 2004
We describes a study in which conventional wisdom about congenital malformations was investigated, the two main objectives being to list mothers' ideas by comparing six well-known causes of congenital abnormalities (ingestion of alcoholic beverages ...
Gilberto de Lima Garcias, Lavínia Schüler-Faccini   +1 more
doaj   +1 more source

In vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice

Chemical Research in Toxicology, 2013
In vivo drug interactions of the teratogen thalidomide with the model cytochrome P450 (P450) 3A substrate midazolam were investigated in mice with humanized livers.
H. Yamazaki, H. Suemizu, N. Murayama, M. Utoh, N. Shibata, Masato Nakamura, F. Guengerich   +6 more
semanticscholar   +1 more source

Generative Artificial Intelligence Utilization and Perspectives Among Reproductive‐Age Women With Systemic Autoimmune and Rheumatic Diseases

Arthritis Care &Research, EarlyView.
Objective Reproductive‐age women with systemic autoimmune and rheumatic diseases (SARDs) have unique information needs related to their SARDs and reproductive health. We sought to understand their use of and receptivity to current and hypothetical generative artificial intelligence (AI) tools for health information‐seeking. Methods We conducted a cross‐
Mariam Arif, Catherine Wright, Samantha Rodriguez, Sarah Graves, Tamar Krishnamurti, Mehret Birru Talabi   +5 more
wiley   +1 more source

Chemical-Induced Cleft Palate Is Caused and Rescued by Pharmacological Modulation of the Canonical Wnt Signaling Pathway in a Zebrafish Model

Frontiers in Cell and Developmental Biology, 2020
Cleft palate is one of the most frequent birth defects worldwide. It causes severe problems regarding eating and speaking and requires long-term treatment. Effective prenatal treatment would contribute to reducing the risk of cleft palate.
Rika Narumi, Shujie Liu, Naohiro Ikeda, Osamu Morita, Junichi Tasaki   +4 more
doaj   +1 more source

PENGUJIAN SIFAT TERATOGEN BORAKS PADA MENCIT PUTIH [PDF]

, 2010
The hazard material bora,x which also call "bleng and pijer" tend tomisuse as conservatives in many foodstuff. Inasmuch as the accumulation of borax to be predicted as cancer stimulant hereby the report of teratogenicity assessment using white mice.
A, Almahdy, Ahmad, Asram
core  

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]

, 2008
The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
P. D. Soldato, L. Hudak, A. Atmaca, Hudak, Lukasz, A. Sparatore, S. A. Wedel, R. A. Blaheta, Jüngel, Eva, Sparatore, Anna, Blaheta, Roman A., Wedel, Steffen Alexander, D. Jonas, S. E. Al Batran, E. Juengel, Jonas, Dietger, Soldato, Piero Del, Batran, Salah-Eddin al-, Atmaca, Akin   +17 more
core   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Specialists' Decisions in Choosing Diagnostic Imaging Methods in Pregnant Patients with Multiple Traumas, 2024 [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān
Introduction: Traumas are unpredictable injuries during pregnancy that are associated with high mortality and maternal and fetal injuries. Choosing the correct imaging modality in trauma of pregnant mothers is important to reduce the possible exposure of
Seyyed Mahdi Zia Ziabari, Mohammad Hossein Ashough, Seyyed Mostafa Zia Ziabari, Roya Kabodmehri, Zoubin Souri, , Naema Khodadadi-Hassankiadeh, Nazanin Nouri Roudsari   +6 more
doaj   +1 more source

Gene Environment Interactions in the Etiology of Neural Tube Defects

Frontiers in Genetics, 2021
Human structural congenital malformations are the leading cause of infant mortality in the United States. Estimates from the United States Center for Disease Control and Prevention (CDC) determine that close to 3% of all United States newborns present ...
Richard H. Finnell, Richard H. Finnell, Carlo Donato Caiaffa, Sung-Eun Kim, Yunping Lei, John Steele, Xuanye Cao, Gabriel Tukeman, Ying Linda Lin, Robert M. Cabrera, Bogdan J. Wlodarczyk   +10 more
doaj   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source