Results 211 to 220 of about 31,463 (288)

Hydranencephaly in Neonate With Prenatal Exposure to Alcohol During Pregnancy

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Hydranencephaly (HE) is a rare congenital condition characterized by near‐total absence of the cerebral hemispheres, replaced by cerebrospinal fluid, most commonly resulting from in utero bilateral internal carotid artery occlusion; although maternal alcohol consumption is associated with fetal neurodevelopmental abnormalities, its direct role
Dibya Raj Chaudhary, Diwakar Koirala, Samiksha Lamichhane, Bivek Mishra   +3 more
wiley   +1 more source

First Case Report of Agnathia–Otocephaly Complex Reported in Niger

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Agnathia–otocephaly complex (AOC) is an extremely rare congenital malformation resulting from a disorder of the first branchial arch. In the past, this condition was considered lethal. However, milder variants of the isolated type of AOC have been reported as non‐lethal.
Hamidou Soumana Diaouga, Yves Zakari Kossi Odjo Dogbe, Rahamatou Madeleine Garba, Madi Nayama   +3 more
wiley   +1 more source

Cangrelor Bridge for Repeat Cesarean After Third Trimester Percutaneous Coronary Intervention for Total Occlusion NSTEMI

Clinical Case Reports, Volume 14, Issue 6, June 2026.
Visual Summary, case timeline of non‐ST‐elevation MI with PCI followed by cangrelor bridge for classical cesarean delivery. ABSTRACT Acute coronary syndrome is an uncommon but potentially life‐threatening complication in pregnancy, and dual antiplatelet therapy presents challenges in patients requiring cesarean delivery.
Vidya N. Mullangi, Sara Folk, Sneha Sharma, Gillian Belnavis, Shea Macielak, Danielle Blais, Talal Attar, Blair Suter, William H. Marshall V   +8 more
wiley   +1 more source

Consensus on the Clinical Use of Pregabalin in Peripheral Neuropathic Pain

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Pregabalin, a second‐generation α2δ calcium‐channel ligand, exerts potent analgesic effects in peripheral neuropathic pain by reducing calcium influx, suppressing excitatory neurotransmitter release, and decreasing neuronal hyperexcitability. Based on a PRISMA‐guided review of 139 studies and multidisciplinary expert consensus, pregabalin demonstrates ...
Hui Lu, Yuefeng Rao, Jian Wang, Wan Shuanglin, Du Dongping, Ma Ke, Zhiying Feng, Suming Tian, Weidong Qiu, Xu Jing, Zhongwei zhao, Zhenhua Zeng, Benyan Luo, Changqing Wang, Hui Zhao, Kaiming Liu, Li Lin, Xianfeng Zhang, Gong Liyan, Haiqi Lu, Yan Liu, Qingwei Zhao, Yihe Hu   +22 more
wiley   +1 more source

Epigenetic Perspectives on Maternal Gut Microbiota's Impact on Embryonic and Fetal Development

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how maternal health and nutrition shape gut microbiota via epigenetics to regulate embryonic development. It highlights microbiota‐embryo interactions, disruption by prenatal chemical exposures, and personalized nutrition for disease prevention, offering novel insights and therapeutic targets.
Shoulong Xu, Yanjiao Huang, Chenyue Hu, Wenli Ding, Zhenwei Pu, Qiang Li, Zhiliang Xu   +6 more
wiley   +1 more source

Oncogenic and teratogenic effects of Trp53 ^Y217C , an inflammation-prone mouse model of the human hotspot mutant TP53 ^Y220C

Jaber S, Eldawra E, Rakotopare J, Simeonova I, Lejour V, Gabriel M, Cañeque T, Volochtchouk V, Licaj M, Fajac A, Rodriguez R, Morillon A, Bardot B, Toledo F.   +13 more
europepmc   +1 more source

Association of Neurodevelopmental Disorders and Congenital Anomalies With Prenatal Multiple Sclerosis Treatment—Real‐World Historical Cohort Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1565-1573, June 2026.
There is a paucity of data regarding the effects of prenatal disease‐modifying therapies (DMTs) for multiple sclerosis (MS), on congenital anomalies in the offspring. Moreover, data on the association with neurodevelopmental disorders are lacking. This is an historical cohort study, within the Israeli Clalit Health Services database (2005–2024) that ...
Bar Rosh, Ofek Levi, Nili Stein, Amir Yahav, Naomi Gronich   +4 more
wiley   +1 more source

Association of COVID-19 vaccination before 12 weeks of gestation with ultrasound-detected congenital anomalies compared with later or no vaccination: A registry-based cohort study. [PDF]

SAGE Open Med
Taghavi SA, Bazarganipour F, Moradi-Joo M, Seyedi Z, Dabiri F, Bozorgian L, Manzori L.   +6 more
europepmc   +1 more source

Optimal Dose and Safety of Intravenous Favipiravir in Hospitalized Patients With COVID‐19: A Dose‐Escalating, Randomized Controlled Phase Ib Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1650-1661, June 2026.
AGILE (NCT04746183) is a Phase Ib/IIa platform, evaluating candidates to treat COVID‐19. Candidate Specific Trial 6 evaluated the safety and optimal dose of a novel intravenous formulation of favipiravir in a dose‐escalating, open‐label, randomized, controlled, Bayesian adaptive Phase Ib trial.
Tim Rowland, Richard FitzGerald, Elizabeth Challenger, Laura Dickinson, Laura J. Else, Lauren Walker, Colin Hale, Victoria Shaw, Callum Kelly, Rebecca Lyon, Jennifer Gibney, Karim Dhamani, Margaret Irwin, Yvanne Enever, Michelle Tetlow, William Wood, Helen Reynolds, Justin Chiong, Orod Osanlou, Henry Pertinez, Katie Bullock, William Greenhalf, Andrew Owen, David G. Lalloo, Michael Jacobs, Julian A. Hiscox, Thomas Jaki, Pavel Mozgunov, Geoffrey Saunders, Gareth Griffiths, Saye H. Khoo, Thomas E. Fletcher, on behalf of the AGILE CST‐6 Study Group, Shazaad Ahmad, Christopher J. Edwards, Lesley Dry, Georgie McKenzie, Aleksandra Ros, Michael Stackpoole, Laura Bradley, Karen Jennings‐Wilding, Nicholas Paton, Fred Hayden, Janet Darbyshire, Amy Lucas, Ulrika Lorch, Andrew Freedman, Richard Knight, Steven Julious   +48 more
wiley   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source