Results 61 to 70 of about 31,463 (288)

Teratogenic effects of drugs [PDF]

, 2019
Klinički pokusi na trudnicama se ne provode iz etičkih razloga. Rezultat toga je nedostatak podataka o djelovanju lijekova u trudnoći. Lijekovi mogu proći kroz posteljicu i uzrokovati teratogene nuspojave na embrij/fetus.
Minković, Mia
core  

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Teratogenic effects of ochratoxin a in rabbits.

World Rabbit Science, 2010
[EN] Ochratoxin A, is a food-borne mycotoxin produced by several fungal species of the genera Aspergillus and Penicillium. Ochratoxin A was dissolved in corn oil and given by gastric intubation to rabbits on days 6-18 of gestation with the dose levels of 0.025, 0.050 and 0.100 mg/kg body weight. When compared with controls (4.16 %), in case of 0.100 mg/
Wangikar, P.B., Dwivedi, P., Sinha, N.
openaire   +4 more sources

Identification of major congenital malformations based on healthcare databases in France: A proof‐of‐concept study using the epi‐meres nationwide mother–child register

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Besides registries, healthcare databases can provide useful information for assessing the frequency of major congenital malformations (MCMs) and investigating their risk factors, particularly medication exposures. This study aimed to assess the validity of MCMs identification based on French national, comprehensive healthcare databases ...
Tom Duchemin, Lise Marty, Jérôme Drouin, Sara Miranda, Jérémie Botton, Valérie Olié, Alain Weill, Rosemary Dray‐Spira   +7 more
wiley   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Effects of folic acid on prevention of developmental malformations due to chronic consumption of acetaminophen in mice

مجله دانشگاه علوم پزشکی گرگان, 2007
Background&Objective: Acetaminophen is a drug that is used commonly in the all time of pregnancy as a antipyretic and analgestic. The aim of this study was to determine teratogenic effects of this drug when it is used continuously before and during ...
Afshar M, Hamy J, Boghrati M
doaj  

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Benzene histotoxic and teratogenic Effects in exposed Mice

Kufa Journal for Veterinary Medical Sciences, 2017
Throughout the last two decades, benzene was a prominent source of an occupational and environmental pollution in Iraq. Especially from direct contact with private electric generators which were installed closer to homes or even inside every home in ...
Hussamadin kadhim, Ahmed Majeed Al-Shammari, Amer Tawfeeq, Maeda Mohammad, Ayman Hassan   +4 more
doaj   +1 more source

Teratogenic effects of ciprofloxacin and pefloxacin in pregnant rats [PDF]

Veterinary Medical Journal - Giza, 2011
  The adverse effects of ciprofloxacin and pefloxacin on rat fetuses following oral administration to the pregnant rats were studied. Ciprofloxacin and pefloxacin were given daily to pregnant rats at two (therapeutic and double therapeutic) dosage levels
Shalaby A, El-Gendi Y, Hassan S
doaj   +1 more source

Teratogenic effects of vitamin A on embryos of pregnant rats

, 2022
Vitamin A is lipid soluble vitamin widely used during pregnancy as a food supplement. The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2021 and February 2022, thirty female Albino Rats are used.
Ali, Ashraf Raoof Mohammed, Abood, Ali Hassan   +1 more
core   +1 more source